DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV

Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection

(2016) Beatrice Ondondo et al.   MOLECULAR THERAPY

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

(2016) S. G. Hansen et al.   SCIENCE

A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology

(2016) Jie Liu et al.   PLoS Pathogens

Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083

(2015) Stephen R. Walsh et al.   JOURNAL OF INFECTIOUS DISEASES

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

(2015) Beatriz Mothe et al.   Journal of Translational Medicine

The Breadth of Expandable Memory CD8+T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers

(2015) Zaza M. Ndhlovu et al.   JOURNAL OF VIROLOGY

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

(2015) Cornelia L Trimble et al.   LANCET

Recombinant rubella vectors elicit SIV Gag-specific T cell responses with cytotoxic potential in rhesus macaques

(2015) Margherita Rosati et al.   VACCINE

Antigenic requirement for Gag in a vaccine that protects against high-dose mucosal challenge with simian immunodeficiency virus

(2015) John B. Schell et al.   VIROLOGY

Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques

(2014) Antonio Valentin et al.   CLINICAL IMMUNOLOGY

Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques

(2014) Viraj Kulkarni et al.   PLoS One

HIV-1 Conserved Elements p24CE DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques

(2014) Viraj Kulkarni et al.   PLoS One

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

(2014) Tae Jin Kim et al.   Nature Communications

HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity

(2013) M. Rolland et al.   JOURNAL OF VIROLOGY

Vaccine-elicited Human T Cells Recognizing Conserved Protein Regions Inhibit HIV-1

(2013) Nicola Borthwick et al.   MOLECULAR THERAPY

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

HIV-1 p24gag Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice

(2013) Viraj Kulkarni et al.   PLoS One

DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge

(2013) V. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic DNA Vaccines: Improved Vaccine Potency by Electroporation and Co-Delivered Genetic Adjuvants

(2013) Seleeke Flingai et al.   Frontiers in Immunology

Full-Length HIV-1 Immunogens Induce Greater Magnitude and Comparable Breadth of T Lymphocyte Responses to Conserved HIV-1 Regions Compared with Conserved-Region-Only HIV-1 Immunogens in Rhesus Monkeys

(2012) K. E. Stephenson et al.   JOURNAL OF VIROLOGY

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control

(2012) Beatriz Mothe et al.   PLoS One

Broad and Cross-Clade CD4+ T-Cell Responses Elicited by a DNA Vaccine Encoding Highly Conserved and Promiscuous HIV-1 M-Group Consensus Peptides

(2012) Rafael Ribeiro Almeida et al.   PLoS One

Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

(2012) M. L. Bagarazzi et al.   Science Translational Medicine

IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques

(2012) Rashmi Jalah et al.   Human Vaccines & Immunotherapeutics

Clinical Applications of DNA Vaccines: Current Progress

(2011) B. Ferraro et al.   CLINICAL INFECTIOUS DISEASES

Significant Protection against High-Dose Simian Immunodeficiency Virus Challenge Conferred by a New Prime-Boost Vaccine Regimen

(2011) J. B. Schell et al.   JOURNAL OF VIROLOGY

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

(2011) V. Dahirel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focus and breadth of cellular immune responses elicited by a heterologous insert prime-boost vaccine regimen in rhesus monkeys

(2011) David R. Kaufman et al.   VACCINE

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques

(2010) Maximillian Rosario et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-Cell Correlates of Vaccine Efficacy after a Heterologous Simian Immunodeficiency Virus Challenge

(2010) M. A. Martins et al.   JOURNAL OF VIROLOGY

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

(2010) Dan H Barouch et al.   NATURE MEDICINE

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys

(2010) Sampa Santra et al.   NATURE MEDICINE

Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization

(2010) Vainav Patel et al.   VACCINE

Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit

(2010) Antonio Valentin et al.   VACCINE

Structural and Functional Constraints Limit Options for Cytotoxic T-Lymphocyte Escape in the Immunodominant HLA-B27-Restricted Epitope in Human Immunodeficiency Virus Type 1 Capsid

(2008) A. Schneidewind et al.   JOURNAL OF VIROLOGY

Comparison of Immunogen Designs That Optimize Peptide Coverage: Reply to Fischer et al.

(2008) David C. Nickle et al.   PLoS Computational Biology

Broad and Gag-Biased HIV-1 Epitope Repertoires Are Associated with Lower Viral Loads

(2008) Morgane Rolland et al.   PLoS One

Identification of immunogenic HLA-B7 “Achilles’ heel” epitopes within highly conserved regions of HIV

(2008) Anne S. De Groot et al.   VACCINE