The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease

The Microbiome and the Respiratory Tract

(2016) Robert P. Dickson et al.   Annual Review of Physiology

Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function

(2016) Jennifer A. Manuzak et al.   JOURNAL OF IMMUNOLOGY

Gut Microbiota Regulates K/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells

(2016) Katharine E. Block et al.   JOURNAL OF IMMUNOLOGY

An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Microbiota-Mediated Inflammation and Antimicrobial Defense in the Intestine

(2015) Silvia Caballero et al.   Annual Review of Immunology

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm

(2015) Christopher J. Ryerson et al.   EUROPEAN RESPIRATORY JOURNAL

Innate immunity alterations in idiopathic interstitial pneumonias and rheumatoid arthritis-associated interstitial lung diseases

(2015) Ilias C. Papanikolaou et al.   IMMUNOLOGY LETTERS

Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia

(2015) Stefanie Gauguet et al.   INFECTION AND IMMUNITY

No Vacancy: How Beneficial Microbes Cooperate with Immunity To Provide Colonization Resistance to Pathogens

(2015) Martina Sassone-Corsi et al.   JOURNAL OF IMMUNOLOGY

Anti-Inflammatory Effects of Lactobacillus Rahmnosus and Bifidobacterium Breve on Cigarette Smoke Activated Human Macrophages

(2015) Esmaeil Mortaz et al.   PLoS One

Gut microbiota and aging

(2015) P. W. OToole et al.   SCIENCE

US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis

(2015) R Andres Floto et al.   THORAX

Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin

(2015) S. Knippenberg et al.   THORAX

The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma

(2015) Richard Hewitt et al.   Therapeutic Advances in Respiratory Disease

CFTR and lung homeostasis

(2014) James F. Collawn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Early Respiratory Microbiota Composition Determines Bacterial Succession Patterns and Respiratory Health in Children

(2014) Giske Biesbroek et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

(2014) Phillip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Nasal and Sinus Microbiome in Health and Disease

(2014) Michael T. Wilson et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Central role of IL-17/Th17 immune responses and the gut microbiota in the pathogenesis of intestinal fibrosis

(2014) Shuvra Ray et al.   CURRENT OPINION IN GASTROENTEROLOGY

Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa

(2014) L. Millares et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Early Innate Immunity to Bacterial Infection in the Lung Is Regulated Systemically by the Commensal Microbiota via Nod-Like Receptor Ligands

(2014) Thomas B. Clarke   INFECTION AND IMMUNITY

Airway Microbiome Dynamics in Exacerbations of Chronic Obstructive Pulmonary Disease

(2014) Y. J. Huang et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

(2014) Jian Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development and Survival of Th17 Cells within the Intestines: The Influence of Microbiome- and Diet-Derived Signals

(2014) Joseph H. Chewning et al.   JOURNAL OF IMMUNOLOGY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

(2014) Eva S Gollwitzer et al.   NATURE MEDICINE

Disrupted Intestinal Microbiota and Intestinal Inflammation in Children with Cystic Fibrosis and Its Restoration with Lactobacillus GG: A Randomised Clinical Trial

(2014) Eugenia Bruzzese et al.   PLoS One

Changes in the Lung Microbiome following Lung Transplantation Include the Emergence of Two Distinct Pseudomonas Species with Distinct Clinical Associations

(2014) Robert P. Dickson et al.   PLoS One

Respiratory microbiota: addressing clinical questions, informing clinical practice

(2014) Geraint B Rogers et al.   THORAX

Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study

(2014) MeiLan K Han et al.   Lancet Respiratory Medicine

Respiratory Outbreak ofMycobacterium abscessusSubspeciesmassiliensein a Lung Transplant and Cystic Fibrosis Center

(2013) Moira L. Aitken et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Philip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Toll-like Receptor 3 L412F Polymorphism and Disease Progression in Idiopathic Pulmonary Fibrosis

(2013) David N. O’Dwyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

(2013) Alison Morris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection

(2013) Yohsuke Tomosada et al.   BMC IMMUNOLOGY

IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation

(2013) Z. Tan et al.   JOURNAL OF IMMUNOLOGY

Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri

(2013) Virginia A Folcik et al.   MODERN PATHOLOGY

MALDI-TOF MS Distinctly Differentiates Nontypable Haemophilus influenzae from Haemophilus haemolyticus

(2013) Bingqing Zhu et al.   PLoS One

Deep Sequencing Identifies Ethnicity-Specific Bacterial Signatures in the Oral Microbiome

(2013) Matthew R. Mason et al.   PLoS One

Exacerbation phenotyping in chronic obstructive pulmonary disease

(2013) Martin MacDonald et al.   RESPIROLOGY

IL-17 in lung disease: friend or foe?

(2013) Hui-Leng Tan et al.   THORAX

Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation

(2013) Leopoldo N Segal et al.   Microbiome

Unique microbial communities persist in individual cystic fibrosis patients throughout a clinical exacerbation

(2013) Katherine E Price et al.   Microbiome

Lung-enriched Organisms and Aberrant Bacterial and Fungal Respiratory Microbiota after Lung Transplant

(2012) Emily S. Charlson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease

(2012) Marc A. Sze et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway impedance entropy and exacerbations in severe asthma

(2012) Sherif Gonem et al.   EUROPEAN RESPIRATORY JOURNAL

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Asthma-associated differences in microbial composition of induced sputum

(2012) Pradeep Reddy Marri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis

(2012) M.N. Hurley et al.   Journal of Cystic Fibrosis

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Genetic variation in Toll-like receptors and disease susceptibility

(2012) Mihai G Netea et al.   NATURE IMMUNOLOGY

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease

(2012) Alexa A. Pragman et al.   PLoS One

Decade-long bacterial community dynamics in cystic fibrosis airways

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmentalized Control of Skin Immunity by Resident Commensals

(2012) S. Naik et al.   SCIENCE

The Th17 Pathway in Cystic Fibrosis Lung Disease

(2011) Hui-Leng Tan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Low diversity of the gut microbiota in infants with atopic eczema

(2011) Thomas R. Abrahamsson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?

(2011) Franziska A. Stressmann et al.   Journal of Cystic Fibrosis

Dual TCR Expression Biases Lung Inflammation in DO11.10 Transgenic Mice and Promotes Neutrophilia via Microbiota-Induced Th17 Differentiation

(2011) M. M. Lemaire et al.   JOURNAL OF IMMUNOLOGY

Transient TLR Activation Restores Inflammatory Response and Ability To Control Pulmonary Bacterial Infection in Germfree Mice

(2011) C. T. Fagundes et al.   JOURNAL OF IMMUNOLOGY

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

The skin microbiome

(2011) Elizabeth A. Grice et al.   NATURE REVIEWS MICROBIOLOGY

Exposure to Environmental Microorganisms and Childhood Asthma

(2011) Markus J. Ege et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD

(2011) John R. Erb-Downward et al.   PLoS One

Detection of Herpes Simplex Virus Type-1 in Patients with Fibrotic Lung Diseases

(2011) Ismini Lasithiotaki et al.   PLoS One

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma

(2010) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis

(2010) Charles R. Esther et al.   Journal of Cystic Fibrosis

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

(2010) Mark S. Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Airway Microbiota and Pathogen Abundance in Age-Stratified Cystic Fibrosis Patients

(2010) Michael J. Cox et al.   PLoS One

The Human Nasal Microbiota and Staphylococcus aureus Carriage

(2010) Daniel N. Frank et al.   PLoS One

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR9 Differentiates Rapidly from Slowly Progressing Forms of Idiopathic Pulmonary Fibrosis

(2010) G. Trujillo et al.   Science Translational Medicine

Sarcoidosis is a Th1/Th17 multisystem disorder

(2010) M. Facco et al.   THORAX

ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses

(2009) Ville Pulkkinen et al.   FASEB JOURNAL

Heterogeneity of Vaginal Microbial Communities within Individuals

(2009) T. K. Kim et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The Role of the IL23/IL17 Axis in Bronchiolitis Obliterans Syndrome After Lung Transplantation

(2008) B. M. Vanaudenaerde et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis

(2008) Yoshito Ishizaki et al.   JOURNAL OF NEUROVIROLOGY

A double blind randomised placebo controlled pilot study of oral co-trimoxazole in advanced fibrotic lung disease

(2007) V.A. Varney et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS