CD275-Independent IL-17–Producing T Follicular Helper–like Cells in Lymphopenic Autoimmune-Prone Mice

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

(2016) Celi Sun et al.   NATURE GENETICS

Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells

(2014) John P. Ray et al.   IMMUNITY

Preferential Development of CD4 and CD8 T Regulatory Cells in RasGRP1-Deficient Mice

(2014) Xiaoxi Chen et al.   JOURNAL OF IMMUNOLOGY

Nasal Anti-CD3 Antibody Ameliorates Lupus by Inducing an IL-10-Secreting CD4+CD25-LAP+ Regulatory T Cell and Is Associated with Down-Regulation of IL-17+CD4+ICOS+CXCR5+ Follicular Helper T Cells

(2014) H. Y. Wu et al.   JOURNAL OF IMMUNOLOGY

B7RP-1 Blockade Ameliorates Autoimmunity through Regulation of Follicular Helper T Cells

(2014) Y.-L. Hu et al.   JOURNAL OF IMMUNOLOGY

Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice

(2014) Yanna Ding et al.   Arthritis & Rheumatology

Multiple Checkpoint Breach of B Cell Tolerance in Rasgrp1-Deficient Mice

(2013) A. Bartlett et al.   JOURNAL OF IMMUNOLOGY

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation

(2013) J. L. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

(2013) Stephen R Daley et al.   eLife

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

The origins, function, and regulation of T follicular helper cells

(2012) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Murine Regulatory T Cells Contain Hyperproliferative and Death-Prone Subsets with Differential ICOS Expression

(2012) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain

(2012) Deirdre M. Fuller et al.   PLoS One

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

(2011) R. Goenka et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

(2011) Danelle Eto et al.   PLoS One

Elevated Th17 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis

(2011) Qian Xing et al.   RHEUMATOLOGY INTERNATIONAL

Abnormalities of T cell signaling in systemic lupus erythematosus

(2011) Vaishali R Moulton et al.   ARTHRITIS RESEARCH & THERAPY

Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis

(2010) O. Frey et al.   ANNALS OF THE RHEUMATIC DISEASES

IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells

(2010) Maria H. Lexberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pharmacologic Inhibition of MEK–ERK Signaling Enhances Th17 Differentiation

(2010) Andy Hee-Meng Tan et al.   JOURNAL OF IMMUNOLOGY

IL-17 Activates the Canonical NF-κB Signaling Pathway in Autoimmune B Cells of BXD2 Mice To Upregulate the Expression of Regulators of G-Protein Signaling 16

(2010) Shutao Xie et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6-lpr/lpr Mice

(2010) V. C. Kyttaris et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1

(2010) W. Pan et al.   JOURNAL OF IMMUNOLOGY

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

Proinflammatory T helper type 17 cells are effective B-cell helpers

(2010) M. Mitsdoerffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus

(2010) Sebastian Dolff et al.   ARTHRITIS RESEARCH & THERAPY

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

(2010) Kamini Shah et al.   ARTHRITIS RESEARCH & THERAPY

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

(2009) Michelle A. Linterman et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Yin-Yang of costimulation: crucial controls of immune tolerance and function

(2009) Roza I. Nurieva et al.   IMMUNOLOGICAL REVIEWS

ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus

(2009) J. M. Odegard et al.   JOURNAL OF IMMUNOLOGY

Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies

(2009) H Q Qu et al.   JOURNAL OF MEDICAL GENETICS

Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells

(2009) HY Wu et al.   LUPUS

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice

(2007) Mohammed Javeed I. Ansari et al.   CLINICAL IMMUNOLOGY