SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis

Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

(2022) Hiroko Otsuka et al.   BIOCHEMICAL JOURNAL

Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis

(2022) Jun Lin et al.   Cell Death & Disease

Trends in myocarditis incidence, complications and mortality in Sweden from 2000 to 2014

(2022) Michael Fu et al.   Scientific Reports

Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway

(2022) Hui Zhang et al.   Journal of Inflammation Research

The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice

(2021) Jifei Chen et al.   MEDIATORS OF INFLAMMATION

The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin

(2021) Vincenzo Quagliariello et al.   Cardiovascular Diabetology

Canagliflozin and myocardial oxidative stress: SGLT1 inhibition takes centre stage

(2021) Gabriele G Schiattarella et al.   EUROPEAN HEART JOURNAL

Effects of canagliflozin on human myocardial redox signalling: clinical implications

(2021) Hidekazu Kondo et al.   EUROPEAN HEART JOURNAL

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2021) Theresa A McDonagh et al.   EUROPEAN HEART JOURNAL

Cardioprotection by SGLT2 Inhibitors—Does It All Come Down to Na+?

(2021) Maximilian Trum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiac ectopic lymphoid follicle formation in viral myocarditis involving the regulation of podoplanin in Th17 cell differentiation

(2021) Mingxin Zhu et al.   FASEB JOURNAL

Combined effect of canagliflozin and exercise training on high fat diet-fed mice

(2020) Kenichi Tanaka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure

(2020) Nikole J. Byrne et al.   Circulation-Heart Failure

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

(2020) Antonio Abbate et al.   CIRCULATION RESEARCH

SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease

(2020) So Ra Kim et al.   Nature Communications

Haploinsufficient Rock1+/− and Rock2+/− Mice Are Not Protected from Cardiac Inflammation and Postinflammatory Fibrosis in Experimental Autoimmune Myocarditis

(2020) Karolina Tkacz et al.   Cells

Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways

(2020) Raquibul Hasan et al.   Scientific Reports

Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK–Akt–eNOS pathway in the isoprenaline-induced oxidative stress model

(2020) Raquibul Hasan et al.   Scientific Reports

Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling

(2019) Yong ZOU et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leptin facilitates the differentiation of Th17 cells from MRL/Mp-Fas lpr lupus mice by activating NLRP3 inflammasome

(2019) Yiyun Yu et al.   Innate Immunity

Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)

(2018) Karin Rådholm et al.   CIRCULATION

NLRP3 inflammasome regulates Th17 differentiation in rheumatoid arthritis

(2018) Chunmei Zhao et al.   CLINICAL IMMUNOLOGY

Gemcitabine nanoparticles promote antitumor immunity against melanoma

(2018) Yuan Zhang et al.   BIOMATERIALS

Viral myocarditis—diagnosis, treatment options and current controversies

(2015) Ari Pollack et al.   Nature Reviews Cardiology

Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis

(2014) Yan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Formation of the inflammasome in acute myocarditis

(2014) Stefano Toldo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Interleukin-1 Receptor and Caspase-1 Are Required for the Th17 Response in Nitrogen Dioxide–Promoted Allergic Airway Disease

(2013) Rebecca A. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mononuclear cell secretome protects from experimental autoimmune myocarditis

(2013) Konrad Hoetzenecker et al.   EUROPEAN HEART JOURNAL

Suppressor of Cytokine Signaling 1 DNA Administration Inhibits Inflammatory and Pathogenic Responses in Autoimmune Myocarditis

(2012) K. Tajiri et al.   JOURNAL OF IMMUNOLOGY

Update on Myocarditis

(2012) Ingrid Kindermann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 Cells Contribute to Viral Replication in Coxsackievirus B3-Induced Acute Viral Myocarditis

(2010) J. Yuan et al.   JOURNAL OF IMMUNOLOGY

Apoptosis in Patients With Acute Myocarditis

(2009) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states

(2009) S. K. Banerjee et al.   CARDIOVASCULAR RESEARCH

Enterovirus-related activation of the cardiomyocyte mitochondrial apoptotic pathway in patients with acute myocarditis

(2009) L. Venteo et al.   EUROPEAN HEART JOURNAL

Th17 Cells Facilitate the Humoral Immune Response in Patients with Acute Viral Myocarditis

(2009) Jing Yuan et al.   JOURNAL OF CLINICAL IMMUNOLOGY