Leptin facilitates the differentiation of Th17 cells from MRL/Mp-Fas lpr lupus mice by activating NLRP3 inflammasome

Effect of induction therapy on circulating T-helper 17 and T-regulatory cells in active proliferative lupus nephritis

(2018) Sajjan Shenoy et al.   International Journal of Rheumatic Diseases

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome regulates Th17 differentiation in rheumatoid arthritis

(2018) Chunmei Zhao et al.   CLINICAL IMMUNOLOGY

Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β

(2017) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis

(2017) Valeria Diaz-Rizo et al.   PLoS One

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

(2016) Hui Zhang et al.   Journal of Translational Medicine

T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

(2016) Bradley N Martin et al.   NATURE IMMUNOLOGY

Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation

(2016) Elaine V. Lourenço et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Deficient Leptin Signaling Ameliorates Systemic Lupus Erythematosus Lesions in MRL/Mp-Faslpr Mice

(2014) Y. Fujita et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1 Receptor and Caspase-1 Are Required for the Th17 Response in Nitrogen Dioxide–Promoted Allergic Airway Disease

(2013) Rebecca A. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Leptin-Induced ROR t Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus

(2013) Y. Yu et al.   JOURNAL OF IMMUNOLOGY

An Essential Role of Caspase 1 in the Induction of Murine Lupus and Its Associated Vascular Damage

(2013) J. Michelle Kahlenberg et al.   Arthritis & Rheumatology

Bone marrow-derived and synovium-derived mesenchymal cells promote Th17 cell expansion and activation through caspase 1 activation: Contribution to the chronicity of rheumatoid arthritis

(2012) Assia Eljaafari et al.   ARTHRITIS AND RHEUMATISM

Cutting Edge: Fasting-Induced Hypoleptinemia Expands Functional Regulatory T Cells in Systemic Lupus Erythematosus

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Distinct Licensing of IL-18 and IL-1β Secretion in Response to NLRP3 Inflammasome Activation

(2012) Rebecca L. Schmidt et al.   PLoS One

High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids

(2011) M. McMahon et al.   ANNALS OF THE RHEUMATIC DISEASES

Uric Acid-Driven Th17 Differentiation Requires Inflammasome-Derived IL-1 and IL-18

(2011) C. Conforti-Andreoni et al.   JOURNAL OF IMMUNOLOGY

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY