Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin

Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice*

(2015) Ranran Li et al.   CRITICAL CARE MEDICINE

TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis

(2014) Miriam H. P. van Lieshout et al.   INFLAMMATION RESEARCH

Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo

(2014) Piotr S. Kowalski et al.   JOURNAL OF CONTROLLED RELEASE

The flow dependency of Tie2 expression in endotoxemia

(2013) Neng F. Kurniati et al.   INTENSIVE CARE MEDICINE

Effective siRNA delivery to inflamed primary vascular endothelial cells by anti-E-selectin and anti-VCAM-1 PEGylated SAINT-based lipoplexes

(2013) Niek G.J. Leus et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type-Specific Functions of TLR4 during Sepsis

(2013) M. Deng et al.   JOURNAL OF IMMUNOLOGY

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Endothelial RIG-I activation impairs endothelial function

(2012) Tobias Asdonk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutrophils Express Distinct RNA Receptors in a Non-canonical Way

(2012) Michael Berger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis

(2011) Sascha David et al.   CYTOKINE

Retinoic acid inducible gene-I, more than a virus sensor

(2011) Feng Liu et al.   Protein & Cell

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Sepsis and Endothelial Permeability

(2010) Warren L. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combination of Imipenem and TAK-242, a Toll-Like Receptor 4 Signal Transduction Inhibitor, Improves Survival in a Murine Model of Polymicrobial Sepsis

(2010) Takukyu Sha et al.   SHOCK

Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo

(2009) E. Jin et al.   BLOOD

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

(2008) Xiaobing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE