The DNA Damage Response Regulates RAG1/2 Expression in Pre–B Cells through ATM-FOXO1 Signaling

NF- B and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity

(2015) K. Ochodnicka-Mackovicova et al.   BLOOD

Spatio-temporal regulation of RAG2 following genotoxic stress

(2015) William Rodgers et al.   DNA REPAIR

The Ataxia Telangiectasia Mutated and Cyclin D3 Proteins Cooperate To Help Enforce TCRβ and IgH Allelic Exclusion

(2014) Natalie C. Steinel et al.   JOURNAL OF IMMUNOLOGY

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

(2014) Elli Papaemmanuil et al.   NATURE GENETICS

Pre-B Cell Receptor Signaling Induces Immunoglobulin κ Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions

(2014) Ralph Stadhouders et al.   PLOS BIOLOGY

The Ataxia Telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondaryVκ-to-Jκrearrangements

(2013) Natalie C. Steinel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MK5 activatesRagtranscription via Foxo1 in developing B cells

(2013) Kwan T. Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal evolution in hematological malignancies and therapeutic implications

(2013) D A Landau et al.   LEUKEMIA

The BCL11A Transcription Factor Directly Activates RAG Gene Expression and V(D)J Recombination

(2013) Baeck-seung Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of SIRT1 activity by genotoxic stress

(2012) J. Yuan et al.   GENES & DEVELOPMENT

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

(2012) Kyoko Ochiai et al.   NATURE IMMUNOLOGY

DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

(2012) Laura Zannini et al.   Journal of Molecular Cell Biology

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

(2012) Esmé Waanders et al.   PLoS Genetics

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks

(2011) Michael Fraser et al.   CELL CYCLE

Coupling of V(D)J Recombination to the Cell Cycle Suppresses Genomic Instability and Lymphoid Tumorigenesis

(2011) Li Zhang et al.   IMMUNITY

GSK690693 Delays Tumor Onset and Progression in Genetically Defined Mouse Models Expressing Activated Akt

(2010) D. A. Altomare et al.   CLINICAL CANCER RESEARCH

Efficient and stable transduction of resting B lymphocytes and primary chronic lymphocyte leukemia cells using measles virus gp displaying lentiviral vectors

(2009) C. Frecha et al.   BLOOD

Caspase activation pathways: some recent progress

(2009) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms controlling expression of the RAG locus during lymphocyte development

(2009) Tracy C Kuo et al.   CURRENT OPINION IN IMMUNOLOGY

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development

(2009) Malay Mandal et al.   NATURE IMMUNOLOGY

AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines

(2008) D. S. Levy et al.   BLOOD

Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

(2008) N. Rhodes et al.   CANCER RESEARCH

A Multicolor Panel of Novel Lentiviral “Gene Ontology” (LeGO) Vectors for Functional Gene Analysis

(2008) Kristoffer Weber et al.   MOLECULAR THERAPY

Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

(2008) Rupesh H Amin et al.   NATURE IMMUNOLOGY

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY

The FoxO code

(2008) D R Calnan et al.   ONCOGENE