Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis

A systemic defect in Toll-like receptor 4 signaling increases lipopolysaccharide-induced suppression of IL-2-dependent T-cell proliferation in COPD

(2016) Jürgen Knobloch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Current research in necrotizing enterocolitis

(2016) Simon Eaton et al.   EARLY HUMAN DEVELOPMENT

Year in Review 2015: Neonatal Respiratory Care

(2016) S. E. Courtney   Respiratory Care

Perinatal conditions related to growth restriction and inflammation are associated with an increased risk of bronchopulmonary dysplasia

(2015) Lena Eriksson et al.   ACTA PAEDIATRICA

HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4Significance

(2015) Jingjing Cai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut

(2015) Chhinder P. Sodhi et al.   JOURNAL OF IMMUNOLOGY

Oral Administration of Surfactant Protein-A Reduces Pathology in an Experimental Model of Necrotizing Enterocolitis

(2015) Hector D. Quintanilla et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor

(2015) M Good et al.   Mucosal Immunology

Causes and Timing of Death in Extremely Premature Infants from 2000 through 2011

(2015) Ravi M. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis of anti -inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4)

(2015) Peter Wipf et al.   TETRAHEDRON LETTERS

TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury

(2015) Jie Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9

(2014) Misty Good et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges

(2014) Peng Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review

(2014) Ben Lu et al.   Expert Review of Clinical Immunology

Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis

(2014) Amin Afrazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine downregulates TLR-2 and TLR-4 expression and protects intestinal tract in preterm neonatal rats with necrotizing enterocolitis

(2014) Wei Zhou et al.   JOURNAL OF PEDIATRIC SURGERY

Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis

(2014) Di Meng et al.   PEDIATRIC RESEARCH

Long term healthcare costs of infants who survived neonatal necrotizing enterocolitis: a retrospective longitudinal study among infants enrolled in Texas Medicaid

(2013) Vaidyanathan Ganapathy et al.   BMC Pediatrics

Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice

(2013) Gary W. Nace et al.   HEPATOLOGY

Carbon monoxide–based therapy ameliorates acute pancreatitis via TLR4 inhibition

(2013) Jing Xue et al.   JOURNAL OF CLINICAL INVESTIGATION

A Critical Role for TLR4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis

(2013) M. D. Neal et al.   JOURNAL OF IMMUNOLOGY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

(2013) Matthew D. Neal et al.   PLoS One

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling

(2013) Ibrahim Yazji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

During apoptosis HMGB1 is translocated into apoptotic cell-derived membraneous vesicles

(2012) Martin Schiller et al.   AUTOIMMUNITY

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

(2012) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice

(2012) Junjie Mei et al.   JOURNAL OF CLINICAL INVESTIGATION

Intracellular Heat Shock Protein-70 Negatively Regulates TLR4 Signaling in the Newborn Intestinal Epithelium

(2012) A. Afrazi et al.   JOURNAL OF IMMUNOLOGY

Activation of Toll-Like Receptor 4 Is Necessary for Trauma Hemorrhagic Shock-Induced Gut Injury and Polymorphonuclear Neutrophil Priming

(2012) Diego C. Reino et al.   SHOCK

Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine

(2011) Yuying Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases

(2011) Richard H. Siggers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of Microbiota, Toll-like Receptors, and Their Regulators in the Small Intestinal Mucosa in Celiac Disease

(2011) Marko Kalliomäki et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection

(2011) C E Egan et al.   Mucosal Immunology

Necrotizing Enterocolitis

(2011) Josef Neu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet-Activating Factor Induces TLR4 Expression in Intestinal Epithelial Cells: Implication for the Pathogenesis of Necrotizing Enterocolitis

(2010) Antoine Soliman et al.   PLoS One

Extracellular High Mobility Group Box-1 (HMGB1) Inhibits Enterocyte Migration via Activation of Toll-like Receptor-4 and Increased Cell-Matrix Adhesiveness

(2009) Shipan Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Lung Disease and Developmental Delay at 2 Years of Age in Children Born Before 28 Weeks' Gestation

(2009) M. Laughon et al.   PEDIATRICS

Endotoxin Induced Chorioamnionitis Prevents Intestinal Development during Gestation in Fetal Sheep

(2009) Tim G. A. M. Wolfs et al.   PLoS One