Pathogenic Neisseria Bind the Complement Protein CFHR5 via Outer Membrane Porins

CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy

(2020) Peter F. Zipfel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of Novel Neisseria gonorrhoeae Lineages Harboring Resistance Plasmids in Coastal Kenya

(2018) Ana Cehovin et al.   JOURNAL OF INFECTIOUS DISEASES

Structure-based design of chimeric antigens for multivalent protein vaccines

(2018) S. Hollingshead et al.   Nature Communications

Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4

(2018) Richard B. Pouw et al.   Frontiers in Immunology

Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children

(2018) Anna E. van Beek et al.   Frontiers in Immunology

Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics

(2017) Sanjay Ram et al.   Pathogens and Disease

Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

(2017) Anna E. van Beek et al.   Frontiers in Immunology

Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

(2016) Nicole Schäfer et al.   Frontiers in Immunology

Binding of Complement Factor H to PorB3 and NspA Enhances Resistance of Neisseria meningitidis to Anti-Factor H Binding Protein Bactericidal Activity

(2015) Serena Giuntini et al.   INFECTION AND IMMUNITY

Factor H–Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation

(2015) Ádám I. Csincsi et al.   JOURNAL OF IMMUNOLOGY

Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces

(2015) Q. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human Factor H Interacts Selectively with Neisseria gonorrhoeae and Results in Species-Specific Complement Evasion

(2014) J. Ngampasutadol et al.   JOURNAL OF IMMUNOLOGY

Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility

(2014) Joseph JE Caesar et al.   eLife

Structure-Function Studies of the Neisseria gonorrhoeae Major Outer Membrane Porin

(2013) Adrienne Chen et al.   INFECTION AND IMMUNITY

Saturating Mutagenesis of an Essential Gene: a Majority of the Neisseria gonorrhoeae Major Outer Membrane Porin (PorB) Is Mutable

(2013) A. Chen et al.   JOURNAL OF BACTERIOLOGY

Complement factor H related proteins (CFHRs)

(2013) Christine Skerka et al.   MOLECULAR IMMUNOLOGY

Human complement control and complement evasion by pathogenic microbes – Tipping the balance

(2013) Peter F. Zipfel et al.   MOLECULAR IMMUNOLOGY

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factor H-Dependent Alternative Pathway Inhibition Mediated by Porin B Contributes to Virulence of Neisseria meningitidis

(2013) L. A. Lewis et al.   mBio

Distinct Binding and Immunogenic Properties of the Gonococcal Homologue of Meningococcal Factor H Binding Protein

(2013) Ilse Jongerius et al.   PLoS Pathogens

Acute Presentation and Persistent Glomerulonephritis Following Streptococcal Infection in a Patient With Heterozygous Complement Factor H–Related Protein 5 Deficiency

(2012) Katherine A. Vernon et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Structure and function of the PorB porin from disseminatingNeisseria gonorrhoeae

(2012) Kornelius Zeth et al.   BIOCHEMICAL JOURNAL

Characterization of Neisseria meningitidis Isolates That Do Not Express the Virulence Factor and Vaccine Antigen Factor H Binding Protein

(2011) Jay Lucidarme et al.   Clinical and Vaccine Immunology

Factor H Facilitates Adherence of Neisseria gonorrhoeae to Complement Receptor 3 on Eukaryotic Cells

(2010) S. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis

(2010) Daniel P Gale et al.   LANCET

Complement control protein factor H: The good, the bad, and the inadequate

(2010) Viviana P. Ferreira et al.   MOLECULAR IMMUNOLOGY

Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease

(2010) Sonia Davila et al.   NATURE GENETICS

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Complement Factor H-Related Proteins CFHR2 and CFHR5 Represent Novel Ligands for the Infection-Associated CRASP Proteins of Borrelia burgdorferi

(2010) Corinna Siegel et al.   PLoS One

Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB

(2010) M. Tanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Meningococcal Vaccine Candidate Neisserial Surface Protein A (NspA) Binds to Factor H and Enhances Meningococcal Resistance to Complement

(2010) Lisa A. Lewis et al.   PLoS Pathogens

Factor H family proteins and human diseases

(2008) Mihály Józsi et al.   TRENDS IN IMMUNOLOGY

Complement factor H related proteins in immune diseases

(2008) Christine Skerka et al.   VACCINE

The Staphylococcus aureus Protein Sbi Acts as a Complement Inhibitor and Forms a Tripartite Complex with Host Complement Factor H and C3b

(2008) Katrin Haupt et al.   PLoS Pathogens