Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency

(2017) Taco W. Kuijpers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Circulating complement factor H–related proteins 1 and 5 correlate with disease activity in IgA nephropathy

(2017) Nicholas R. Medjeral-Thomas et al.   KIDNEY INTERNATIONAL

Elevated factor H–related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy

(2017) Agustín Tortajada et al.   KIDNEY INTERNATIONAL

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy

(2017) Shambhuprasad K. Togarsimalemath et al.   KIDNEY INTERNATIONAL

Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome

(2016) S. Hyvarinen et al.   BLOOD

Complement factor H in host defense and immune evasion

(2016) Raffaella Parente et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Familial C3 glomerulonephritis caused by a novel CFHR5-CFHR2 fusion gene

(2016) Xue Xiao et al.   MOLECULAR IMMUNOLOGY

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

(2016) Nicole Schäfer et al.   Frontiers in Immunology

Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

(2016) Richard B. Pouw et al.   PLoS One

Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions

(2016) Jonathan P. Hannan et al.   PLoS One

Therapeutic TNF Inhibitors can Differentially Stabilize Trimeric TNF by Inhibiting Monomer Exchange

(2016) Karin A. van Schie et al.   Scientific Reports

Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome

(2015) Maria E. Bernabéu-Herrero et al.   MOLECULAR IMMUNOLOGY

Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange

(2014) Theo Rispens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Atypical Hemolytic Uremic Syndrome-Associated Hybrid CFHR1/CFH Gene Encoding a Fusion Protein That Antagonizes Factor H-Dependent Complement Regulation

(2014) E. Valoti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration

(2013) Morad Ansari et al.   HUMAN MOLECULAR GENETICS

Complement factor H–related hybrid protein deregulates complement in dense deposit disease

(2013) Qian Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay

(2013) Reecha Sofat et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A novel CFHR5 fusion protein causes C3 glomerulopathy in a family without Cypriot ancestry

(2013) Nicholas Medjeral-Thomas et al.   KIDNEY INTERNATIONAL

Human Factor H-Related Protein 2 (CFHR2) Regulates Complement Activation

(2013) Hannes U. Eberhardt et al.   PLoS One

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Presentation and Persistent Glomerulonephritis Following Streptococcal Infection in a Patient With Heterozygous Complement Factor H–Related Protein 5 Deficiency

(2012) Katherine A. Vernon et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Complement dysregulation and disease: From genes and proteins to diagnostics and drugs

(2012) Santiago Rodriguez de Cordoba et al.   IMMUNOBIOLOGY

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein

(2012) Mario Hebecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene

(2012) Dineke Westra et al.   JOURNAL OF HUMAN GENETICS

A Hybrid CFHR3-1 Gene Causes Familial C3 Glomerulopathy

(2012) T. H. Malik et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Comprehensive Analysis of Copy Number Variation of Genes at Chromosome 1 and 10 Loci Associated with Late Age Related Macular Degeneration

(2012) Stuart Cantsilieris et al.   PLoS One

Mechanism of Immunoglobulin G4 Fab-arm Exchange

(2011) Theo Rispens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Translational Mini-Review Series on Complement Factor H: Renal diseases associated with complement factor H: novel insights from humans and animals

(2010) M. C. Pickering et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome

(2010) Svetlana Hakobyan et al.   KIDNEY INTERNATIONAL

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis

(2010) Daniel P Gale et al.   LANCET

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

(2009) S. Heinen et al.   BLOOD

Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome

(2009) C. Abarrategui-Garrido et al.   BLOOD

Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome

(2009) Markus J. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY