Article
Biochemistry & Molecular Biology
Kai Yang, Yuezhong Jin, Ming Cai, Pengfei He, Baoming Tian, Rongfa Guan, Genrong Yu, Peilong Sun
Summary: The polysaccharide PPW-1 from Phellinus pini has strong potential hypoglycemic activity by inhibiting alpha-glucosidase, improving insulin resistance. It is a homogeneous heteropolysaccharide composed of glucose, mannose, galactose, and rhamnose, with a unique structure that includes both branched and linear chains.
Article
Pharmacology & Pharmacy
Xiaoya Zhu, Ruirui Guo, Xiayu Su, Kun Shang, Conglian Tan, Junheng Ma, Yuemeng Zhang, Dan Lin, Yueran Ma, Min Zhou, Jiale Yang, Qiqi Wu, Jiale Sun, Zhuoling Wang, Yuyue Guo, Ruifan Su, Xiangyi Cui, Jiming Han, Yuhong Lu, Changwu Yue
Summary: The polysaccharides and flavonoids derived from Phellinus igniarius have immune-enhancing activity and antioxidant properties. They stimulate the expression and secretion of IL-2, IL-6, and IFN-γ in immune cells while inhibiting TNF-α expression and secretion. These compounds also affect the metabolic response of short-chain fatty acids in the intestines and alter the composition and abundance of gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junhyok Ryang, Fang Liu, Tzi Bun Ng
Summary: Through isolation and purification, this study identified a catechin antioxidant component, PP-S4-1, from Phellinus pini, which showed therapeutic effects on oxidative stress damage in H9c2 cells.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Engineering, Chemical
Ming-Yu Lung, Kai-Wen Deng
Summary: Phellinu igniarius is a medicinal fungus with anticancer and antioxidant properties. This study investigated the production of polysaccharide in submerged culture of P. igniarius using surfactant, and found that Tween 80 exhibited the greatest exopolysaccharide production.
Article
Plant Sciences
Xia Li, Jie Gao, Miaomiao Li, Hao Cui, Wei Jiang, Zong-cai Tu, Tao Yuan
Summary: A chemical investigation on the fruiting bodies of Phellinus pini led to the isolation of five aromatic cadinane sesquiterpenoids which inhibited the SARS-CoV-2 spike-ACE2 interaction, suggesting their potential in developing COVID-19 agents. The molecular docking study showed the mechanism of action of compound 1 in disrupting the interaction between SARS-CoV-2 and ACE2.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Applied
Shiqiang Wang, Gang Li, Xinfei Zhang, Yuqian Wang, Yi Qiang, Bulei Wang, Jiabin Zou, Junfeng Niu, Zhezhi Wang
Summary: Polysaccharides obtained from Polygonatum sibiricum (PSP) were purified and characterized in this study. The PSP1 sample had the highest content and best solubility. The main sugar residue linkages were identified as 1)-beta-D-Fruf-(2 -> 1)-beta-D-Fruf-(2 -> 1), 1 -> -beta-D-Fruf-(2 -> 6)alpha-D-Glcp (1 ->,-> 4)-beta-D-Manp-(1 -> 4)-beta-D-Manp-(1 -> and -> 6)-beta-D-Glcp-(1 -> 4)-beta-D-Manp-(1 ->. Branch chain analysis revealed the presence of -> 1,6)-beta-D-Fruf-(2 ->, beta-D-Fruf-(2 ->,-> 1,6)-beta-D-Fruf-(2 ->,-> 6)-beta-D-Fruf(2 -> linkages, with the link site at position C-6. In vitro antioxidant activity tests showed that PSP1 had scavenging effects on DPPH, hydroxyl radical, superoxide anion radical, and exhibited a specific chelating ability for ferrous ions. These findings suggest that P. sibiricum polysaccharides may possess potential antioxidant properties.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Hui-Rong Yang, Lian-Hong Chen, Ying-Jie Zeng
Summary: The novel homogeneous polysaccharide extracted from Tricholoma matsutake demonstrated strong antioxidant activity and inhibition on alpha-glucosidase and a-amylase activities. Furthermore, treatment with this polysaccharide significantly improved glucose consumption, glycogen synthesis, and the activities of various enzymes in insulin-resistant-human hepatoma cell line (IR-HepG2), suggesting great potential in managing type 2 diabetes mellitus.
Article
Food Science & Technology
Zongping Zhu, Jiao Chen, Yi Chen, Yuntong Ma, Qingsong Yang, Yunqiu Fan, Chaomei Fu, Boonjai Limsila, Rui Li, Wan Liao
Summary: This study focused on the extraction, structure, and antioxidant activity of turmeric polysaccharides (TPs). Different polysaccharide fractions were purified and analyzed, with TPs-2 exhibiting the strongest antioxidant effects. Overall, the results indicated that TPs have great potential as natural antioxidants in functional foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Kazem Medlej, Cherri Batoul, Hamza Olleik, Suming Li, Akram Hijazi, Ghassan Nasser, Marc Maresca, Celine Pochat-Bohatier
Summary: The study aimed to investigate the properties of biopolymers extracted from a non-edible Lebanese onion plant under different extraction conditions. Results showed that extracts obtained with 50% ultrasound treatment exhibited the best antioxidant activity, while certain extracts were found to be non-toxic to human cells.
Article
Food Science & Technology
Feng Li, Yu Jin, Jun Wang, Huaide Xu
Summary: This study isolated two polysaccharides, MSP1-1 and MSP1-2, from mushrooms of the Morchella genus, and found that they exhibit good thermal stability and antioxidant activity. MSP1-1 is a glucan, while MSP1-2 is a galactomannan with a network structure, which is observed for the first time.
Article
Biochemistry & Molecular Biology
Virginia Casas-Arrojo, Juan Decara, Maria de los Angeles Arrojo-Agudo, Claudia Perez-Manriquez, Roberto T. Abdala-Diaz
Summary: Porphyridium cruentum's sulfated polysaccharides exhibit strong immunomodulatory and cytotoxic effects, inducing IL-6 cytokines and TNF-alpha. They show potential as a valuable ingredient in nutraceutical products.
Review
Biochemistry & Molecular Biology
Sechul Chun, Judy Gopal, Manikandan Muthu
Summary: This article discusses the medicinal properties and bioactivity of mushrooms, focusing on the antioxidant and antiviral properties of mushroom polysaccharides. It also points out the relatively limited research on mushroom polysaccharides compared to overall mushroom studies.
Review
Chemistry, Applied
Fei Luan, Xi Peng, Ge Zhao, Jiuseng Zeng, Junbo Zou, Zhili Rao, Yao Liu, Xiumeng Zhang, Hang Ma, Nan Zeng
Summary: Phellinus spp., an important medicinal fungus mushroom cultivated and consumed in East Asia for over 2000 years, has polysaccharides as major bioactive macromolecules with multiple health-promoting effects. While extraction and purification methods, structural characteristics, and pharmacological activities of these polysaccharides have been extensively studied, there is limited knowledge on their structures and bioactivity relationship, toxicologic effects, and pharmacokinetic profile. This review systematically summarizes recent progress in the isolation and purification, chemical structures, bioactivities, and underlying mechanisms of PPs, providing insights for their further development as therapeutic agents and functional foods.
Article
Acoustics
Zhenjie Tang, Yanrong Wang, Gangliang Huang, Hualiang Huang
Summary: According to the response surface methodology, the optimized conditions for ultrasound-assisted extraction of polysaccharide from Garcinia mangostana L. rinds were determined. Acetylation significantly improved the antioxidant activity of the polysaccharide. Chemical modification is an effective method to improve the properties of polysaccharides, indicating the great research value and potential of Garcinia mangostana L. polysaccharide.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Food Science & Technology
Guoyong Yu, Jing Zhao, Yunlu Wei, Linlin Huang, Fei Li, Yu Zhang, Quanhong Li
Summary: In this study, subcritical water (SCW) was used to modify pumpkin polysaccharides, leading to changes in rheological and emulsifying properties. Different treatment temperatures resulted in variations in molecular weight distribution and enhanced antioxidant activity. The results demonstrate that SCW treatment is an effective method for improving solution properties and antioxidant activity of pumpkin polysaccharides.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)