Regulatory T Cell Dysfunction Acquiesces to BTLA+Regulatory B Cells Subsequent to Oral Intervention in Experimental Autoimmune Encephalomyelitis

IL-10-independent regulatory B-cell subsets and mechanisms of action: Table 1.

(2015) Avijit Ray et al.   INTERNATIONAL IMMUNOLOGY

B cell recognition of myelin oligodendrocyte glycoprotein autoantigen depends on immunization with protein rather than short peptide, while B cell invasion of the CNS in autoimmunity does not

(2015) Amy K. Dang et al.   JOURNAL OF NEUROIMMUNOLOGY

PD-L1hi B cells are critical regulators of humoral immunity

(2015) Adnan R. Khan et al.   Nature Communications

Interleukin-10+Regulatory B Cells Arise Within Antigen-Experienced CD40+B Cells to Maintain Tolerance to Islet Autoantigens

(2014) Sonja Kleffel et al.   DIABETES

Low-Dose Tolerance Is Mediated by the Microfold Cell Ligand, Reovirus Protein  1

(2014) A. Rynda et al.   JOURNAL OF IMMUNOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

The Effect of Glatiramer Acetate Therapy on Functional Properties of B Cells From Patients With Relapsing-Remitting Multiple Sclerosis

(2014) Sara J. Ireland et al.   JAMA Neurology

The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer

(2013) Lequn Li et al.   CLINICAL IMMUNOLOGY

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

(2013) Hong Nie et al.   NATURE MEDICINE

Nogo-Receptor 1 Deficiency Has No Influence on Immune Cell Repertoire or Function during Experimental Autoimmune Encephalomyelitis

(2013) Sara A. Litwak et al.   PLoS One

Innate pro-B-cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cells

(2013) R. Montandon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

Antibody-independent B cell effector functions in relapsing remitting Multiple Sclerosis: Clues to increased inflammatory and reduced regulatory B cell capacity

(2012) Sara J. Ireland et al.   AUTOIMMUNITY

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Lymphocytes Treated In Vitro with Antigen Coupled to Cholera Toxin B Subunit Induce Antigen-Specific Foxp3+ Regulatory T Cells and Protect against Experimental Autoimmune Encephalomyelitis

(2012) J.-B. Sun et al.   JOURNAL OF IMMUNOLOGY

A Novel IL-10-Independent Regulatory Role for B Cells in Suppressing Autoimmunity by Maintenance of Regulatory T Cells via GITR Ligand

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Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway

(2011) Y. Sakoda et al.   BLOOD

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes

(2011) S. Fourlanos et al.   DIABETES

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

(2011) Elisabeth Calderón-Gómez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tolerogen-induced interferon-producing killer dendritic cells (IKDCs) protect against EAE

(2011) Eduardo Huarte et al.   JOURNAL OF AUTOIMMUNITY

IFN-γ– and IL-10–expressing virus epitope-specific Foxp3+T reg cells in the central nervous system during encephalomyelitis

(2011) Jingxian Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm

(2010) Helena Batoulis et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity

(2010) Martin S. Weber et al.   ANNALS OF NEUROLOGY

Slow Down and Survive: Enigmatic Immunoregulation by BTLA and HVEM

(2010) Theresa L. Murphy et al.   Annual Review of Immunology

Active immunization using a single dose immunotherapeutic abates established EAE via IL-10 and regulatory T cells

(2010) Agnieszka Rynda-Apple et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

What are regulatory B cells?

(2010) David Gray et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-10 produced by activated human B cells regulates CD4+ T-cell activation in vitro

(2010) Jean-David Bouaziz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glatiramer acetate for treatment of MS: Regulatory B cells join the cast of players

(2010) Luc Van Kaer   EXPERIMENTAL NEUROLOGY

Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression

(2010) Jörn C. Albring et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis

(2010) Sakhina Begum-Haque et al.   JOURNAL OF NEUROIMMUNOLOGY

A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis

(2010) Avijit Ray et al.   JOURNAL OF NEUROIMMUNOLOGY

Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate

(2010) Sakhina Begum-Haque et al.   JOURNAL OF NEUROIMMUNOLOGY

Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children

(2010) PH Lalive et al.   Multiple Sclerosis Journal

IL-28 Supplants Requirement for Treg Cells in Protein σ1-Mediated Protection against Murine Experimental Autoimmune Encephalomyelitis (EAE)

(2010) Agnieszka Rynda et al.   PLoS One

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

(2009) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

B cells from glatiramer acetate-treated mice suppress experimental autoimmune encephalomyelitis

(2009) Mrinalini Kala et al.   EXPERIMENTAL NEUROLOGY

The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation

(2009) Guifang Cai et al.   IMMUNOLOGICAL REVIEWS

Promoting Immune Responses by LIGHT in the Face of Abundant Regulatory T Cell Inhibition

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice

(2009) Wayne Truong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation

(2009) M. L. del Rio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A granulocyte-macrophage colony–stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties

(2009) Moutih Rafei et al.   NATURE MEDICINE

Unconventional ligand activation of herpesvirus entry mediator signals cell survival

(2009) T. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

Regulatory B cells as inhibitors of immune responses and inflammation

(2008) Jean-David Bouaziz et al.   IMMUNOLOGICAL REVIEWS

Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression

(2008) Takashi Matsushita et al.   JOURNAL OF CLINICAL INVESTIGATION

CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator

(2008) Guifang Cai et al.   NATURE IMMUNOLOGY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE