Antibody-independent B cell effector functions in relapsing remitting Multiple Sclerosis: Clues to increased inflammatory and reduced regulatory B cell capacity

Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells

(2014) K. L. Good et al.   JOURNAL OF IMMUNOLOGY

Analysis of cytokine production patterns of peripheral blood mononuclear cells from a rheumatoid arthritis patient successfully treated with rituximab

(2014) Akinori Yamamoto et al.   Modern Rheumatology

The anti-CD20 antibody rituximab reduces the Th17 cell response

(2011) Frank L. van de Veerdonk et al.   ARTHRITIS AND RHEUMATISM

B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis

(2011) Mingxia Zhang et al.   CELLULAR IMMUNOLOGY

Immunotherapeutic implication of IL-6 blockade

(2011) Toshio Tanaka et al.   Immunotherapy

B cells undergo unique compartmentalized redistribution in multiple sclerosis

(2011) Jürgen Haas et al.   JOURNAL OF AUTOIMMUNITY

B Cells as a Therapeutic Target for IFN-β in Relapsing–Remitting Multiple Sclerosis

(2011) Vinod S. Ramgolam et al.   JOURNAL OF IMMUNOLOGY

Mice Lacking Endogenous IL-10-Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells

(2011) N. A. Carter et al.   JOURNAL OF IMMUNOLOGY

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

(2011) Stephanie Knippenberg et al.   JOURNAL OF NEUROIMMUNOLOGY

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

(2011) Ludwig Kappos et al.   LANCET

Rituximab Therapy Reduces Organ-Specific T Cell Responses and Ameliorates Experimental Autoimmune Encephalomyelitis

(2011) Nancy L. Monson et al.   PLoS One

Primary B-Cell Deficiencies Reveal a Link between Human IL-17-Producing CD4 T-Cell Homeostasis and B-Cell Differentiation

(2011) Rita R. Barbosa et al.   PLoS One

B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity

(2010) Martin S. Weber et al.   ANNALS OF NEUROLOGY

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation

(2010) Simona Bancos et al.   CELLULAR IMMUNOLOGY

Correlation of a multi-cytokine panel with clinical disease activity in patients with rheumatoid arthritis

(2010) Nataliya Milman et al.   CLINICAL BIOCHEMISTRY

Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein

(2010) Christopher T. Harp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis

(2010) Siew C. Ng et al.   INFLAMMATORY BOWEL DISEASES

TLR1/2, TLR7, and TLR9 Signals Directly Activate Human Peripheral Blood Naive and Memory B Cell Subsets to Produce Cytokines, Chemokines, and Hematopoietic Growth Factors

(2010) Sudhanshu Agrawal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis

(2010) Makoto Hirotani et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis

(2010) Sakhina Begum-Haque et al.   JOURNAL OF NEUROIMMUNOLOGY

Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate

(2010) Sakhina Begum-Haque et al.   JOURNAL OF NEUROIMMUNOLOGY

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

(2009) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

The Macrophage Mannose Receptor Induces IL-17 in Response to Candida albicans

(2009) Frank L. van de Veerdonk et al.   Cell Host & Microbe

Interferon-β treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1

(2009) George P. Christophi et al.   CLINICAL IMMUNOLOGY

Essential and synergistic roles of IL1 and IL6 in human Th17 differentiation directed by TLR ligand-activated dendritic cells

(2009) Risa K. Benwell et al.   CLINICAL IMMUNOLOGY

B cells from glatiramer acetate-treated mice suppress experimental autoimmune encephalomyelitis

(2009) Mrinalini Kala et al.   EXPERIMENTAL NEUROLOGY

Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enhances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis

(2009) A. Quintana et al.   JOURNAL OF IMMUNOLOGY

Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS

(2009) F. Sellebjerg et al.   NEUROLOGY

Memory and naïve B-cell subsets in patients with multiple sclerosis

(2009) Masaaki Niino et al.   NEUROSCIENCE LETTERS

Helminth infections associated with multiple sclerosis induce regulatory B cells

(2008) Jorge Correale et al.   ANNALS OF NEUROLOGY

Rituximab in relapsing-remitting multiple sclerosis: A 72-week, open-label, phase I trial

(2008) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

Interferon Beta–Induced Restoration of Regulatory T-Cell Function in Multiple Sclerosis Is Prompted by an Increase in Newly Generated Naive Regulatory T Cells

(2008) Mirjam Korporal et al.   ARCHIVES OF NEUROLOGY

Comparison of human B cell activation by TLR7 and TLR9 agonists

(2008) John A Hanten et al.   BMC IMMUNOLOGY

Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis

(2008) Christopher T. Harp et al.   CLINICAL IMMUNOLOGY

The effects of IL-6 on CD4 T cell responses

(2008) Oliver Dienz et al.   CLINICAL IMMUNOLOGY

CD40 Ligand-activated, antigen-specific B cells are comparable to mature dendritic cells in presenting protein antigens and major histocompatibility complex class I- and class II-binding peptides

(2008) Tahamtan Ahmadi et al.   IMMUNOLOGY

Identification of two subpopulations of purified human blood B cells, CD27− CD23+and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6

(2008) Fabrice Cognasse et al.   IMMUNOLOGY

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

(2008) Satoshi Serada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA