Critical Differences between Induced and Spontaneous Mouse Models of Graves’ Disease with Implications for Antigen-Specific Immunotherapy in Humans

Targeting the thyroid-stimulating hormone receptor with small molecule ligands and antibodies

(2015) Terry F Davies et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Current Insights into the Pathogenesis of Graves’ Ophthalmopathy

(2015) R. Bahn   HORMONE AND METABOLIC RESEARCH

Management of Graves Disease

(2015) Henry B. Burch et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease

(2015) Basil Rapoport et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Randomized Controlled Trial of Rituximab in Patients With Graves' Orbitopathy

(2015) Marius N. Stan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Efficacy of B-Cell Targeted Therapy With Rituximab in Patients With Active Moderate to Severe Graves' Orbitopathy: A Randomized Controlled Study

(2015) Mario Salvi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Unique Mouse Strain That Develops Spontaneous, Iodine-Accelerated, Pathogenic Antibodies to the Human Thyrotrophin Receptor

(2015) Basil Rapoport et al.   JOURNAL OF IMMUNOLOGY

Graves’ Disease TSHR-Stimulating Antibodies (TSAbs) Induce the Activation of Immature Thymocytes: A Clue to the Riddle of TSAbs Generation?

(2015) Mireia Giménez-Barcons et al.   JOURNAL OF IMMUNOLOGY

Crystal Structure of a TSH Receptor Monoclonal Antibody: Insight Into Graves' Disease Pathogenesis

(2015) Chun-Rong Chen et al.   MOLECULAR ENDOCRINOLOGY

Antibodies with specificity for native and denatured forms of ovalbumin differ in reactivity between enzyme-linked immunosorbent assays

(2014) Bettina Eide Holm et al.   APMIS

Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity

(2014) M. Stefan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Selective TSH Receptor Antagonist Inhibits Stimulation of Thyroid Function in Female Mice

(2013) Susanne Neumann et al.   ENDOCRINOLOGY

Antigen Targets of Type 1 Diabetes Autoimmunity

(2013) B. O. Roep et al.   Cold Spring Harbor Perspectives in Medicine

The Road Not Taken

(2013) Lawrence Steinman   JAMA Neurology

Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice

(2012) Y. Nagayama et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A 2011 Survey of Clinical Practice Patterns in the Management of Graves' Disease

(2012) Henry B. Burch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

(2012) Julie Zikherman et al.   NATURE

Breaking Tolerance in Transgenic Mice Expressing the Human TSH Receptor A-Subunit: Thyroiditis, Epitope Spreading and Adjuvant as a ‘Double Edged Sword’

(2012) Sandra M. McLachlan et al.   PLoS One

B cell-targeted therapy with anti-CD20 monoclonal antibody in a mouse model of Graves' hyperthyroidism

(2011) I. Ueki et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance

(2011) Roger Colobran et al.   HUMAN MOLECULAR GENETICS

Review and Hypothesis: Does Graves' Disease Develop in Non-Human Great Apes?

(2011) Sandra M. McLachlan et al.   THYROID

Antibodies to Thyroid Peroxidase Arise Spontaneously with Age in NOD.H-2h4 Mice and Appear after Thyroglobulin Antibodies

(2010) Chun-Rong Chen et al.   ENDOCRINOLOGY

Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred mice

(2010) B Rapoport et al.   GENES AND IMMUNITY

Specific immunotherapy of experimental myasthenia gravis by a novel mechanism

(2009) Jie Luo et al.   ANNALS OF NEUROLOGY

Attenuation of Induced Hyperthyroidism in Mice by Pretreatment with Thyrotropin Receptor Protein: Deviation of Thyroid-Stimulating to Nonfunctional Antibodies

(2009) Alexander V. Misharin et al.   ENDOCRINOLOGY

Studies in Mice Deficient for the Autoimmune Regulator (Aire) and Transgenic for the Thyrotropin Receptor Reveal a Role for Aire in Tolerance for Thyroid Autoantigens

(2009) Alexander V. Misharin et al.   ENDOCRINOLOGY

Thyroid Antigens, Not Central Tolerance, Control Responses to Immunization in BALB/c Versus C57BL/6 Mice

(2009) Alexander V. Misharin et al.   THYROID