Targeting the thyroid-stimulating hormone receptor with small molecule ligands and antibodies

Transmembrane Domains of Attraction on the TSH Receptor

(2015) Rauf Latif et al.   ENDOCRINOLOGY

New Small Molecule Agonists to the Thyrotropin Receptor

(2015) Rauf Latif et al.   THYROID

Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes

(2014) Donatella Paolino et al.   BIOMATERIALS

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer

(2014) Xuliang Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperthyroidism and other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinoloigists

(2013) Rebecca Bahn et al.   Endocrine Practice

Novel Insights on Thyroid-Stimulating Hormone Receptor Signal Transduction

(2013) Gunnar Kleinau et al.   ENDOCRINE REVIEWS

A Selective TSH Receptor Antagonist Inhibits Stimulation of Thyroid Function in Female Mice

(2013) Susanne Neumann et al.   ENDOCRINOLOGY

Allosteric Modulators Hit the TSH Receptor

(2013) Terry F. Davies et al.   ENDOCRINOLOGY

G-Protein-Coupled Receptors Signal Victory

(2012) Jeffrey L. Benovic   CELL

Restructuring G-Protein- Coupled Receptor Activation

(2012) Martin Audet et al.   CELL

Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells

(2012) Ruth C. Werthmann et al.   FASEB JOURNAL

Delineating the autoimmune mechanisms in Graves’ disease

(2012) Syed A. Morshed et al.   IMMUNOLOGIC RESEARCH

A Drug-Like Antagonist Inhibits Thyrotropin Receptor–Mediated Stimulation of cAMP Production in Graves' Orbital Fibroblasts

(2012) Susanne Neumann et al.   THYROID

Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor

(2011) Chris J van Koppen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling

(2011) Michael D. Allen et al.   FASEB JOURNAL

A stimulatory TSH receptor antibody enhances adipogenesis via phosphoinositide 3-kinase activation in orbital preadipocytes from patients with Graves' ophthalmopathy

(2011) S. Kumar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

G protein-coupled receptors: mutations and endocrine diseases

(2011) Gilbert Vassart et al.   Nature Reviews Endocrinology

Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor

(2010) Ann-Karin Haas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neutral Antibodies to the TSH Receptor Are Present in Graves’ Disease and Regulate Selective Signaling Cascades

(2010) Syed A. Morshed et al.   ENDOCRINOLOGY

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor

(2010) Gunnar Kleinau et al.   FASEB JOURNAL

Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients

(2010) Heike Biebermann   Frontiers in Bioscience-Landmark

A New Small-Molecule Antagonist Inhibits Graves' Disease Antibody Activation of the TSH Receptor

(2010) Susanne Neumann et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Subunit Interactions Influence TSHR Multimerization

(2010) Rauf Latif et al.   MOLECULAR ENDOCRINOLOGY

Revised guidelines for the management of thyroid cancer

(2010) Kristien Boelaert   Nature Reviews Endocrinology

Graves' Ophthalmopathy

(2010) Rebecca S. Bahn   NEW ENGLAND JOURNAL OF MEDICINE

The Genetics of the Thyroid Stimulating Hormone Receptor: History and Relevance

(2010) Terry F. Davies et al.   THYROID

Treatment of Graves' Disease with Antithyroid Drugs: Current Perspectives

(2010) Kristien Boelaert   THYROID

Presence of a putative steroidal allosteric site on glycoprotein hormone receptors

(2009) Mario Rossi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TSH Receptor – Autoantibody Interactions

(2009) B. Rees Smith et al.   HORMONE AND METABOLIC RESEARCH

The Superagonistic Activity of Bovine Thyroid-stimulating Hormone (TSH) and the Human TR1401 TSH Analog Is Determined by Specific Amino Acids in the Hinge Region of the Human TSH Receptor

(2009) Sandra Mueller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein–protein interactions

(2009) R Núñez Miguel et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

(2009) S. Neumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Propylthiouracil in the Management of Graves' Disease in Adults: Report of a Meeting Jointly Sponsored by the American Thyroid Association and the Food and Drug Administration

(2009) Rebecca S. Bahn et al.   THYROID

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

The specificity of binding of glycoprotein hormones to their receptors

(2008) G. Caltabiano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Low-Molecular-Weight Antagonist for the Human Thyrotropin Receptor with Therapeutic Potential for Hyperthyroidism

(2008) Susanne Neumann et al.   ENDOCRINOLOGY

Characterization of Thyrotropin Receptor Antibody-Induced Signaling Cascades

(2008) Syed A. Morshed et al.   ENDOCRINOLOGY

The Thyrotropin Receptor Hinge Region Is Not Simply a Scaffold for the Leucine-Rich Domain but Contributes to Ligand Binding and Signal Transduction

(2008) Yumiko Mizutori et al.   MOLECULAR ENDOCRINOLOGY

Gβγ Dimers Released in Response to Thyrotropin Activate Phosphoinositide 3-Kinase and Regulate Gene Expression in Thyroid Cells

(2008) Miguel A. Zaballos et al.   MOLECULAR ENDOCRINOLOGY

A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor

(2008) Chris J. van Koppen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY