Article
Endocrinology & Metabolism
Sofie Bliddal, Arash Derakhshan, Yi Xiao, Liang-Miao Chen, Tuija Mannisto, Ghalia Ashoor, Fangbiao Tao, Suzanne J. Brown, Marina Vafeiadi, Sachiko Itoh, Elena Nikolaevna Grineva, Peter Taylor, Farkhanda Ghafoor, Bijay Vaidya, Andrew Hattersley, Lorena Mosso, Emily Oken, Reiko Kishi, Erik K. Alexander, Spyridoula Maraka, Kun Huang, Layal Chaker, Judit Bassols, Amna Pirzada, Abel Lopez-Bermejo, Laura Boucai, Robin P. Peeters, Elizabeth N. Pearce, Scott McGill Nelson, Leda Chatzi, Tanja G. Vrijkotte, Polina V. Popova, John P. Walsh, Kypros H. Nicolaides, Eila Suvanto, Xuemian Lu, Victor J. M. Pop, Julie Lyng Forman, Tim I. M. Korevaar, Ulla Feldt-Rasmussen
Summary: This meta-analysis of individual participant data shows that isolated thyroid peroxidase antibodies (TPOAbs) positivity and thyroglobulin antibodies (TgAbs) positivity during pregnancy are associated with an increase in thyrotropin (TSH), with a more significant effect observed in individuals positive for both antibodies. When adjusting for the other antibody, only TPOAbs remain associated with TSH, indicating a dose-dependent relationship. Further studies are needed to understand the differences between TPOAb- and TgAb-positive women.
Article
Endocrinology & Metabolism
Piotr Kocelak, Aleksander J. Owczarek, Agnieszka Wikarek, Natalia Ogarek, Paulina Oboza, Malgorzata Sieja, Anna Szyszka, Izabela Rozmus-Rogoz, Monika Puzianowska-Kuznicka, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
Summary: This study aimed to assess the frequency of occurrence of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb) in young Caucasian women in connection with various confounders. The results suggest that TSH >= 2.5 mIU/L and a family history of any thyroid diseases justify screening for anti-thyroid antibodies in women of reproductive age.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Ines Bucci, Cesidio Giuliani, Giulia Di Dalmazi, Gloria Formoso, Giorgio Napolitano
Summary: The regulation of the female reproductive system by thyroid hormones is crucial for normal menstrual function, fertility, and successful pregnancy. Thyroid autoimmunity (TAI) is prevalent among women and is associated with infertility and negative reproductive outcomes. The role of TAI, especially in the absence of thyroid dysfunction, in assisted reproductive technology (ART) is still controversial.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Na Zhao, Zhenzhen Wang, Xuejiao Cui, Shuo Wang, Chenling Fan, Yushu Li, Zhongyan Shan, Weiping Teng
Summary: This study confirmed the involvement of miR-326 in regulating Th17/Treg balance in autoimmune thyroiditis using lentiviral gene delivery. MiR-326 targeted therapy shows promising results in the treatment of AIT, and tail vein injection may achieve a better intervention effect than thyroid injection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Carole Ann Spencer
Summary: This review highlights the development of laboratory thyroid tests over the past seven decades, from manual isotopically labeled iodine procedures to automated nonisotopic tests. The introduction of radioimmunoassay techniques and monoclonal antibody technology has played a crucial role in the evolution of thyroid testing. Despite improvements, current tests still face limitations in terms of numerical differences and interferences from reagents and autoantibodies.
Article
Endocrinology & Metabolism
Yingchao Chen, Bing Han, Jie Yu, Yi Chen, Jing Cheng, Chunfang Zhu, Fangzhen Xia, Ningjian Wang, Yingli Lu
Summary: The study found that rapid urbanization is related to the incidence of autoimmune thyroid diseases, indicating a need for increased attention to thyroid autoimmune diseases in rapidly urbanizing areas in China.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Xiang-Qi Kong, Gui-Ying Qiu, Zhong-Bin Yang, Zhi-Xiong Tan, Xiao-Qing Quan
Summary: This study found that selenium supplementation is beneficial for the treatment of Hashimoto's thyroiditis (HT). After 3 months of treatment, there was no significant change in TPOAb levels, but after 6 months, both TPOAb and TgAb levels decreased significantly. Therefore, selenium supplementation can reduce serum TPOAb and TgAb levels in patients with HT.
Article
Medical Laboratory Technology
Sara Deza, Julia Maroto, Olaia Tellechea, Natalia Orbegozo, Juana Merino, Juan C. Galofre, Estibaliz Alegre, Alvaro Gonzalez
Summary: This study evaluated the response to treatment in patients with differentiated thyroid cancer and considered the interference of anti-thyroglobulin antibodies. Results showed discrepancies between two different thyroglobulin quantification methods, but the clinical impact on patient management was minimal.
CLINICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Georgia Kaiafa, Pavlos Tsakiridis, Nikolaos Koukosias, Spyridon Mitsoulis, Christos Savopoulos, Panagiotis Athanassiou
Summary: This study aims to evaluate the relationship between SLE and autoimmune thyroid disease. It found that SLE patients have a higher incidence of clinical thyroid disease and detectable antithyroid antibodies. Evaluating thyroid disease should be considered in SLE patients.
MEDICINA-LITHUANIA
(2023)
Article
Oncology
Dongmei Huang, Jingtai Zhi, Jinming Zhang, Xuan Qin, Jingzhu Zhao, Xiangqian Zheng, Ming Gao
Summary: This study aimed to investigate the relationship between clinicopathological features, prognosis, and preoperative thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) status in children and adolescents with papillary thyroid carcinoma (PTC). The results showed that the presence of preoperative TPOAb and TgAb could serve as novel prognostic factors for predicting recurrence of PTC in children.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Olga Karapanou, Katerina Saltiki, George Simeakis, Efi Botoula, Stylianos Tsagarakis, Maria Alevizaki, Barbara Vlassopoulou
Summary: This study aimed to identify factors affecting anti-Tg persistence and disease outcome in differentiated thyroid cancer patients. Results showed that worse histological features were more common in patients with anti-Tg persistence, and tumor size and extrathyroidal extension were the main predictors of disease progression. Additional radioiodine administration and/or surgeries did not affect anti-Tg elimination in most cases.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olha Kasiyan, Halyna Tkachenko, Natalia Kurhaluk, Svitlana Yurchenko, Alek Manenko
Summary: This study identified correlative and regressive dependencies between water iodine concentration and TSH, TgAbs, and TPOAb levels in hypothyroid patients with Hashimoto's thyroiditis. The results suggest a potential risk of thyroiditis progression, especially among women with additional iodine intake.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Endocrinology & Metabolism
Masahito Katahira, Taku Tsunekawa, Akira Mizoguchi, Mariko Yamaguchi, Kahori Tsuru, Hiromi Takashima, Ryoma Terada
Summary: The clinical significance of thyroglobulin antibodies (TgAbs) and thyroid peroxidase antibodies (TPOAbs) in Graves' disease (GD) were investigated in this study. The results showed that patients positive for TgAbs had lower TRAb titers and shorter remission time, while patients positive for TPOAbs had high TRAb titers and longer remission time.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Siyuan Xu, Hui Huang, Xiaohang Zhang, Ying Huang, Bei Guan, Jiaxin Qian, Xiaolei Wang, Shaoyan Liu, Zhengang Xu, Jie Liu
Summary: The study found that postlobectomy serum thyroglobulin/antithyroglobulin values can be used to predict recurrence in papillary thyroid carcinoma, while also determining optimal cutoff values for first and last thyroglobulin measurements. Patients with elevated thyroglobulin levels have an increased risk of recurrence, and these thresholds can help identify high-risk patients during follow-up.
Article
Endocrinology & Metabolism
Mariacarla Moleti, Angela Alibrandi, Maria Di Mauro, Giuseppe Paola, Laura Giovanna Perdichizzi, Roberta Granese, Annamaria Giacobbe, Angela Scilipoti, Marta Ragonese, Alfredo Ercoli, Salvatore Benvenga, Francesco Vermiglio
Summary: This study aimed to evaluate the prevalence of first-trimester thyroid insufficiency in women with Hashimoto thyroiditis (HT) who had preconception thyrotropin (T-0-TSH) values consistently less than or equal to 2.5 mIU/L, with or without levothyroxine (LT4) treatment. The optimal T-0-TSH cutoffs were found to be 1.24 mIU/L/1.74 mIU/L in HT women on LT4 treatment, and 1.73 mIU/L/2.07 mIU/L in HT women without LT4 treatment. Exceeding these cutoffs significantly increased the risk of first-trimester thyroid insufficiency.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Urology & Nephrology
Kai B. Dallas, Catherine Bresee, Amanda De Hoedt, Justin F. Senechal, Kamil E. Barbour, Jayoung Kim, Stephen J. Freedland, Jennifer T. Anger
Summary: This study explores the association between misdiagnosis of IC/BPS and demographics. The research findings indicate a high rate of misdiagnosis of IC/BPS, with only 48.8% of patients meeting the diagnostic criteria. There were no significant associations between diagnostic accuracy and race/ethnicity, but black and Hispanic patients were diagnosed at a younger age, suggesting potential differences in presentation patterns among racial/ethnic groups.
Article
Medicine, General & Internal
Claire S. Burton, Gabriela Gonzalez, Eunice Choi, Catherine Bresee, Teryl K. Nuckols, Karyn S. Eilber, Neil S. Wenger, Jennifer T. Anger
Summary: Specialists are skilled in managing urinary incontinence, but primary care clinicians play a crucial role in early diagnosis and initiation of management. This study found low rates of adherence to quality indicators for women with urinary incontinence, with female clinicians performing significantly better than male clinicians. Increased years of experience was associated with worse overall care.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Chung Sang Tse, Corey A. Siegel, S. Alandra Weaver, Brant J. Oliver, Catherine Bresee, Welmoed K. van Deen, Gil Y. Melmed
Summary: This study aimed to examine the associations between health confidence, inflammatory bowel disease (IBD) outcomes, and health care utilization among adults with IBD. The study found strong associations between health confidence and patients' well-being, symptomatic disease activity, opioid use, and glucocorticoid use. Patients with low health confidence (<8) were more likely to have frequent interactions with their healthcare provider, IBD-related emergency department visits, and hospitalizations.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Urology & Nephrology
Gabriela Gonzalez, Aman Arora, Eunice Choi, Catherine Bresee, Jonathan Perley, Jennifer T. Anger
Summary: The Supris mid-urethral sling showed significant improvement in symptoms, especially for patients with pre-operative urge incontinence. Despite persistent urge symptoms, patients reported an overall improvement in their symptoms.
Article
Cardiac & Cardiovascular Systems
Fang-zhou Liu, Junaid A. B. Zaman, Ashkan Ehdaie, Yu-mei Xue, Eugenio Cingolani, Catherine Bresee, Sumeet S. Chugh, Shu-lin Wu, Michael Shehata, Xunzhang Wang
Summary: This study utilized noncontact mapping to analyze global conduction patterns in paroxysmal and persistent atrial fibrillation (AF) and their modification during pulmonary vein (PV) ablation. The results showed different conduction patterns between persistent and paroxysmal AF, with PVs remaining a critical region. PV isolation was effective in eliminating PV-related functional phenotypes and affecting the recurrence of other patterns.
Article
Urology & Nephrology
Lauren N. Tholemeier, Catherine Bresee, Amanda M. De Hoedt, Kamil E. Barbour, Jayoung Kim, Stephen J. Freedland, Jennifer T. Anger
Summary: This study found that many women with IC/BPS require multiple bladder prescriptions, highlighting the difficulty in finding an effective treatment. Pentosan polysulfate and hydroxyzine were the preferred medications for IC/BPS.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Surgery
Rebecca L. Paszkiewicz, Miguel A. Burch, Isaac Asare Bediako, Hasmik Mkrtchyan, Francesca Piccinini, Marilyn Ader, Catherine Bresee, Richard N. Bergman
Summary: This study assessed the effects of duodenal exclusion on glucose homeostasis using a DJBL in a nonobese canine model. The results showed that duodenal exclusion induced weight loss and negative metabolic effects, which were reversed upon re-exposure to nutrients.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Endocrinology & Metabolism
Xiao-Hui Liao, Pablo Avalos, Oksana Shelest, Raz Ofan, Michael Shilo, Catherine Bresee, Shibi Likhite, Jean-Philippe Vit, Heike Heuer, Brian Kaspar, Kathrin Meyer, Alexandra M. Dumitrescu, Samuel Refetoff, Clive N. Svendsen, Gad D. Vatine
Summary: Allan-Herndon-Dudley syndrome (AHDS) is a severe psychomotor disability disorder caused by inactivating mutations in monocarboxylate transporter 8 (MCT8). IV delivery of AAV9-MCT8 gene therapy has shown promising results in improving neurological symptoms in mice with AHDS, providing a potential treatment approach for this disorder.
Review
Obstetrics & Gynecology
Lauren Tholemeier, Colby P. Souders, Catherine Bresee, Farnoosh Nik-Ahd, Ashley Caron, Karyn S. Eilber, Jennifer T. Anger
Summary: A better understanding of the effect of elective cesarean delivery (CD) on pelvic floor disorders is important for obstetricians to counsel pregnant women. This systematic review and meta-analysis found that among primiparous women, elective CD may decrease the risk of urinary incontinence compared to CD after trial of labor or vaginal delivery. However, there was no protective effect against fecal incontinence, anal incontinence, or pelvic organ prolapse. More data on elective CD's effect on pelvic organ prolapse are needed.
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Robert H. Baloh, J. Patrick Johnson, Pablo Avalos, Peggy Allred, Soshana Svendsen, Genevieve Gowing, Kristina Roxas, Amanda Wu, Becky Donahue, Sheryl Osborne, George Lawless, Brandon Shelley, Koral Wheeler, Carolyn Prina, Dana Fine, Tami Kendra-Romito, Haniah Stokes, Vicki Manoukian, Abirami Muthukumaran, Leslie Garcia, Maria G. Banuelos, Marlesa Godoy, Catherine Bresee, Hong Yu, Doniel Drazin, Lindsey Ross, Robert Naruse, Harish Babu, Eric A. Macklin, Ashley Vo, Ashraf Elsayegh, Warren Tourtellotte, Marcel Maya, Matthew Burford, Frank Diaz, Chirag G. Patil, Richard A. Lewis, Clive N. Svendsen
Summary: This study demonstrates that human neural progenitor cells modified to release GDNF can be safely transplanted into the spinal cord of ALS patients, providing support cells and GDNF delivery for over 3 years. The transplantation of CNS10-NPC-GDNF has shown to protect spinal motor neurons and have no negative impact on motor function in the treated leg. Furthermore, the transplanted cells have been found to survive and produce GDNF in tissue analysis.
Article
Medicine, General & Internal
Shannon M. Smith, Nance Yuan, Jenna Stelmar, Michael Zaliznyak, Grace Lee, Catherine Bresee, Maurice M. Garcia
Summary: This study aimed to create a nomogram to predict postoperative vaginal depth based on available penile and scrotal skin. The results showed that combining penile and scrotal skin significantly increased depth compared to using penile skin alone.
Article
Biochemical Research Methods
Celina H. Shirazipour, Rachel M. Ruggieri-Bacani, Laura Lockshon, Christopher Waring, Aubrey Jarman, Novalyn Cruz, Catherine Bresee, Angela J. Fong, Pao-Hwa Lin, Gillian Gresham, Arash Asher, Stephen J. Freedland
Summary: This study aims to investigate the feasibility of personalized Zoom-delivered exercise training for breast and prostate cancer survivors, as well as the preliminary efficacy of participation on various health indicators. A 24-week feasibility study will be conducted, involving virtual personal training via Zoom and follow-up exercise using recorded sessions. Physical assessments and surveys will be conducted at multiple time points. Further research is needed to understand the feasibility and effectiveness of virtual exercise programming.
METHODS AND PROTOCOLS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jae Hyung Cho, Alex Rajewski, Catherine Bresee, Myung Yoon Kim, Thassio Mesquita, Xaviar Jones, Isabelle Pellot, Weixin Liu, Lizbeth Sanchez, Asma Nawaz, Ahmed G. Ibrahim, Russell Rogers, Eugenio Cingolani, Eduardo Marban
Meeting Abstract
Urology & Nephrology
Aurash Naser-Tavakolian, John Masterson, Jeremiah Dallmer, Catherine Bresee, Hanson Zhao, Maurice Garcia
JOURNAL OF UROLOGY
(2022)
Meeting Abstract
Urology & Nephrology
Alexandra Dubinskaya, Kyla Smith-Honore, Catherine Bresee, Kai Dallas, Amanda De Hoedt, Jayoung Kim, Stephen Freedland, Jennifer Anger
NEUROUROLOGY AND URODYNAMICS
(2021)