Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development

De novo mutations in children born after medical assisted reproduction

(2022) R M Smits et al.   HUMAN REPRODUCTION

Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF

(2021) Kaichi Yoshizaki et al.   EMBO REPORTS

Aging-induced changes in sperm DNA methylation are modified by low dose of perinatal flame retardants

(2021) J Richard Pilsner et al.   Epigenomics

Sperm DNA methylation mediates the association of male age on reproductive outcomes among couples undergoing infertility treatment

(2021) Oladele A. Oluwayiose et al.   Scientific Reports

Sperm microRNAs confer depression susceptibility to offspring

(2021) Yanbo Wang et al.   Science Advances

Influence of paternal age on assisted reproductive technology cycles and perinatal outcomes

(2021) Audrey M. Marsidi et al.   FERTILITY AND STERILITY

Is increasing paternal age negatively associated with donor oocyte recipient success? A paired analysis using sibling oocytes

(2021) Kelly McCarter et al.   FERTILITY AND STERILITY

Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis

(2021) Guy Morris et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Altered sperm tsRNAs in aged male contribute to anxiety‐like behavior in offspring

(2021) Yi Guo et al.   AGING CELL

Dynamics of cattle sperm sncRNAs during maturation, from testis to ejaculated sperm

(2021) Eli Sellem et al.   Epigenetics & Chromatin

The effects of aging on molecular modulators of human embryo implantation.

(2021) Panagiotis Ntostis et al.   iScience

Small RNAs in epigenetic inheritance: from mechanisms to trait transmission

(2021) Germano Cecere   FEBS LETTERS

All you need to know about sperm RNAs

(2021) Joana Santiago et al.   HUMAN REPRODUCTION UPDATE

The preconception environment and sperm epigenetics

(2020) Chelsea Marcho et al.   Andrology

Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males

(2020) Jinzhao Ma et al.   Aging-US

The demographics of assisted reproductive technology births in a Nordic country

(2020) Alice Goisis et al.   HUMAN REPRODUCTION

Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

(2020) Nadia A du Fossé et al.   HUMAN REPRODUCTION UPDATE

Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice

(2020) Misako Tatehana et al.   PLoS One

Sperm Ribosomal DNA Promoter Methylation Levels Are Correlated With Paternal Aging and May Relate With in vitro Fertilization Outcomes

(2020) Lejun Li et al.   Frontiers in Genetics

Male Infertility is a Women’s Health Issue—Research and Clinical Evaluation of Male Infertility Is Needed

(2020) Katerina A. Turner et al.   Cells

Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline

(2020) Ramya Potabattula et al.   AGING CELL

The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders

(2020) Michelle M. Denomme et al.   AGING CELL

PGC-1α-mediated regulation of mitochondrial function and physiological implications

(2020) Jens Frey Halling et al.   Applied Physiology Nutrition and Metabolism

Relationships between the age of 25,445 men attending infertility clinics and sperm chromatin structure assay (SCSA®) defined sperm DNA and chromatin integrity

(2020) Donald P. Evenson et al.   FERTILITY AND STERILITY

A germ cell‐specific ageing pattern in otherwise healthy men

(2020) Sandra Laurentino et al.   AGING CELL

Autism-like behaviors and abnormality of glucose metabolism in offspring derived from aging males with epigenetically modified sperm

(2020) Wen-Long Zhao et al.   Aging-US

Repeated sampling facilitates within- and between-subject modeling of the human sperm transcriptome to identify dynamic and stress-responsive sncRNAs

(2020) Christopher P. Morgan et al.   Scientific Reports

Sperm miRNAs— potential mediators of bull age and early embryo development

(2020) Chongyang Wu et al.   BMC GENOMICS

The other face of advanced paternal age: a scoping review of its terminological, social, public health, psychological, ethical and regulatory aspects

(2020) Vincent Couture et al.   HUMAN REPRODUCTION UPDATE

High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations

(2020) Mingju Cao et al.   Clinical Epigenetics

Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes

(2019) Fu-Hui Xiao et al.   Frontiers in Genetics

The Neonatal and Adult Human Testis Defined at the Single-Cell Level

(2019) Abhishek Sohni et al.   Cell Reports

Genetic and epigenetic profiling of the infertile male

(2019) Stephanie Cheung et al.   PLoS One

Endogenous Retroviruses Function as Gene Expression Regulatory Elements During Mammalian Pre-implantation Embryo Development

(2019) Bo Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The health of children conceived by ART: ‘the chicken or the egg?’

(2019) Sine Berntsen et al.   HUMAN REPRODUCTION UPDATE

Epigenetic changes during aging and their reprogramming potential

(2019) Alice E. Kane et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Genomic Imprinting and Physiological Processes in Mammals

(2019) Valter Tucci et al.   CELL

Paternal age and assisted reproductive technology: problem solver or trouble maker?

(2019) Mariana Bertoncelli Tanaka et al.   PANMINERVA MEDICA

The role of DEFB126 variation in male infertility and assisted reproductive technique outcome

(2019) Parnaz Borjian Boroujeni et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization

(2019) Minmin Hua et al.   Cell Discovery

The dynamics and regulation of chromatin remodeling during spermiogenesis

(2019) Shuang-Li Hao et al.   GENE

Sperm RNA code programmes the metabolic health of offspring

(2019) Yunfang Zhang et al.   Nature Reviews Endocrinology

Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells

(2019) E. Pohl et al.   Andrology

Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health

(2019) Miguel João Xavier et al.   HUMAN REPRODUCTION UPDATE

De Novo Mutations Reflect Development and Aging of the Human Germline

(2019) J.M. Goldmann et al.   TRENDS IN GENETICS

The effects of di-butyl phthalate exposure from medications on human sperm RNA among men

(2019) Molly Estill et al.   Scientific Reports

Transitions in paternal social status predict patterns of offspring growth and metabolic transcription

(2019) Joseph W. Cauceglia et al.   MOLECULAR ECOLOGY

The age of the bull influences the transcriptome and epigenome of blastocysts produced by IVF

(2019) Chongyang Wu et al.   THERIOGENOLOGY

Age-associated sperm DNA methylation patterns do not directly persist trans-generationally

(2019) Timothy G. Jenkins et al.   Epigenetics & Chromatin

Reproductive genetics and the aging male

(2018) Alexander N. Yatsenko et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice

(2018) Kan Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spermatozoa DNA methylation patterns differ due to peripubertal age in bulls

(2018) Simon Lambert et al.   THERIOGENOLOGY

Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots

(2018) Lars R. Ingerslev et al.   Clinical Epigenetics

Sperm epigenetics and influence of environmental factors

(2018) Ida Donkin et al.   Molecular Metabolism

Driving the next generation: Paternal lifetime experiences transmitted via extracellular vesicles and their small RNA cargo

(2018) Christopher P. Morgan et al.   BIOLOGICAL PSYCHIATRY

Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis

(2018) Yao Chen et al.   CELL RESEARCH

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm

(2018) Upasna Sharma et al.   DEVELOPMENTAL CELL

Paternal germ line aging: DNA methylation age prediction from human sperm

(2018) Timothy G. Jenkins et al.   BMC GENOMICS

Genome-wide differential methylation analyses identifies methylation signatures of male infertility

(2018) Kumar Mohanty Sujit et al.   HUMAN REPRODUCTION

Cytological and molecular aspects of the ageing sperm

(2018) Donatella Paoli et al.   HUMAN REPRODUCTION

RNA element discovery from germ cell to blastocyst

(2018) Molly S Estill et al.   NUCLEIC ACIDS RESEARCH

Advanced paternal age, infertility, and reproductive risks: A review of the literature

(2018) Justin S. Brandt et al.   PRENATAL DIAGNOSIS

Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study

(2018) Yash S Khandwala et al.   BMJ-British Medical Journal

The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids

(2018) Brian P. Hermann et al.   Cell Reports

Common urologic diseases in older men and their treatment: how they impact fertility

(2017) Gabriella Avellino et al.   FERTILITY AND STERILITY

The age of fathers in the USA is rising: an analysis of 168 867 480 births from 1972 to 2015

(2017) Yash S. Khandwala et al.   HUMAN REPRODUCTION

Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse

(2017) Lisa A. Vrooman et al.   REPRODUCTIVE TOXICOLOGY

The DLGAP family: neuronal expression, function and role in brain disorders

(2017) Andreas H. Rasmussen et al.   Molecular Brain

Cigarette smoking significantly alters sperm DNA methylation patterns

(2017) T. G. Jenkins et al.   Andrology

Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition

(2017) Yun Huang et al.   eLife

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants

(2016) Molly S. Estill et al.   FERTILITY AND STERILITY

Âge du père en assistance médicale à la procréation : faut-il une limite ?

(2016) J. Belaisch-Allart et al.   GYNECOLOGIE OBSTETRIQUE & FERTILITE

Effects of aging on the male reproductive system

(2016) Sezgin Gunes et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

Decoding germline de novo point mutations

(2016) Anne Goriely   NATURE GENETICS

Specification and epigenetic programming of the human germ line

(2016) Walfred W. C. Tang et al.   NATURE REVIEWS GENETICS

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

(2016) Qi Chen et al.   NATURE REVIEWS GENETICS

Dnmt2 is the most evolutionary conserved and enigmatic cytosine DNA methyltransferase in eukaryotes

(2016) V. V. Ashapkin et al.   RUSSIAN JOURNAL OF GENETICS

Aging and DNA damage in humans: a meta-analysis study

(2016) Jorge Pinto Soares et al.   Aging-US

Genome-Scale Assessment of Age-Related DNA Methylation Changes in Mouse Spermatozoa

(2016) Norio Kobayashi et al.   PLoS One

Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development

(2016) Nanako Hamada et al.   Scientific Reports

DNA methylation and healthy human aging

(2015) Meaghan J. Jones et al.   AGING CELL

Introduction

(2015) Marcelle I. Cedars   FERTILITY AND STERILITY

Aberrant sperm DNA methylation predicts male fertility status and embryo quality

(2015) Kenneth I. Aston et al.   FERTILITY AND STERILITY

Infertility counseling (or the lack thereof) of the forgotten male partner

(2015) William D. Petok   FERTILITY AND STERILITY

Lifetime development of behavioural phenotype in the house mouse (Mus musculus)

(2015) Vera Brust et al.   Frontiers in Zoology

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

(2015) Rakesh Sharma et al.   Reproductive Biology and Endocrinology

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Absence of sperm RNA elements correlates with idiopathic male infertility

(2015) Meritxell Jodar et al.   Science Translational Medicine

Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis

(2014) Saher Sue Hammoud et al.   Cell Stem Cell

Uniformity of Nucleosome Preservation Pattern in Mammalian Sperm and Its Connection to Repetitive DNA Elements

(2014) Birgit Samans et al.   DEVELOPMENTAL CELL

High-Resolution Mapping of Chromatin Packaging in Mouse Embryonic Stem Cells and Sperm

(2014) Benjamin R. Carone et al.   DEVELOPMENTAL CELL

How to overcome male infertility after 40: Influence of paternal age on fertility

(2014) Stephanie Belloc et al.   MATURITAS

Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression

(2014) M H Milekic et al.   MOLECULAR PSYCHIATRY

Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility

(2014) Timothy G. Jenkins et al.   PLoS Genetics

The presence, role and clinical use of spermatozoal RNAs

(2013) Meritxell Jodar et al.   HUMAN REPRODUCTION UPDATE

Environmental and developmental origins of ovarian reserve

(2013) M.C. Richardson et al.   HUMAN REPRODUCTION UPDATE

Stability, delivery and functions of human sperm RNAs at fertilization

(2013) Edward Sendler et al.   NUCLEIC ACIDS RESEARCH

Cellular Source and Mechanisms of High Transcriptome Complexity in the Mammalian Testis

(2013) Magali Soumillon et al.   Cell Reports

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

(2013) Jafar Kiani et al.   PLoS Genetics

Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice

(2012) Saya Kagiwada et al.   EMBO JOURNAL

The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

(2012) Stefanie Seisenberger et al.   MOLECULAR CELL

Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans

(2012) K. I. Aston et al.   MOLECULAR HUMAN REPRODUCTION

A unique regulatory phase of DNA methylation in the early mammalian embryo

(2012) Zachary D. Smith et al.   NATURE

DNA methylation dynamics during the mammalian life cycle

(2012) J. A. Hackett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

New insights into establishment and maintenance of DNA methylation imprints in mammals

(2012) G. Kelsey et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Parallel mechanisms of epigenetic reprogramming in the germline

(2012) Jamie A. Hackett et al.   TRENDS IN GENETICS

A survey of small RNAs in human sperm

(2011) Stephen A. Krawetz et al.   HUMAN REPRODUCTION

Demographic and medical consequences of the postponement of parenthood

(2011) L. Schmidt et al.   HUMAN REPRODUCTION UPDATE

Cleavage of rRNA ensures translational cessation in sperm at fertilization

(2011) G.D. Johnson et al.   MOLECULAR HUMAN REPRODUCTION

Epigenetics, spermatogenesis and male infertility

(2011) Singh Rajender et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Epigenetic reprogramming in the germline: towards the ground state of the epigenome

(2011) P. Hajkova   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility

(2011) T. L. Tollner et al.   Science Translational Medicine

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

(2010) Urszula Brykczynska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resetting the Epigenome beyond Pluripotency in the Germline

(2009) Katsuhiko Hayashi et al.   Cell Stem Cell

Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men

(2009) Céline Chalas Boissonnas et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences

(2009) A. Arpanahi et al.   GENOME RESEARCH

The human sperm epigenome and its potential role in embryonic development

(2009) D. T. Carrell et al.   MOLECULAR HUMAN REPRODUCTION

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia

(2008) C.J. Marques et al.   MOLECULAR HUMAN REPRODUCTION