Influence of the proton pump inhibitor lansoprazole on distribution and activity of doxorubicin in solid tumors

Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy

(2015) Q Tan et al.   BRITISH JOURNAL OF CANCER

Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma

(2015) Tommaso Azzarito et al.   CANCER LETTERS

Chemotherapy Rescues Hypoxic Tumor Cells and Induces Their Reoxygenation and Repopulation--An Effect That Is Inhibited by the Hypoxia-Activated Prodrug TH-302

(2015) J. K. Saggar et al.   CLINICAL CANCER RESEARCH

Quantitative Immunohistochemistry for Evaluating the Distribution of Ki67 and Other Biomarkers in Tumor Sections and Use of the Method to Study Repopulation in Xenografts after Treatment with Paclitaxel

(2015) Andrea S. Fung et al.   NEOPLASIA

Lansoprazole induces apoptosis of breast cancer cells through inhibition of intracellular proton extrusion

(2014) Shangrong Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

(2014) Stefano Fais et al.   CANCER AND METASTASIS REVIEWS

Autophagy modulation: a target for cancer treatment development

(2014) Alison Duffy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Proton Pump Inhibitors and Histamine 2 Blockers Are Associated with Improved Overall Survival in Patients with Head and Neck Squamous Carcinoma

(2014) S. Papagerakis et al.   Cancer Prevention Research

Autophagy: Detection, regulation and its role in cancer and therapy response

(2014) Pia Hönscheid et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin

(2014) Irene Brana et al.   INVESTIGATIONAL NEW DRUGS

Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells

(2014) Juan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

(2014) Enrico P Spugnini et al.   Journal of Translational Medicine

V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells

(2014) C. M. Schempp et al.   MOLECULAR CANCER THERAPEUTICS

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

(2014) Cristina Federici et al.   PLoS One

S100A8 Contributes to Drug Resistance by Promoting Autophagy in Leukemia Cells

(2014) Minghua Yang et al.   PLoS One

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

Molecular aspects of cancer cell resistance to chemotherapy

(2013) Magali Rebucci et al.   BIOCHEMICAL PHARMACOLOGY

Distribution of the anticancer drugs doxorubicin, mitoxantrone and topotecan in tumors and normal tissues

(2013) Krupa J. Patel et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Use of the Proton Pump Inhibitor Pantoprazole to Modify the Distribution and Activity of Doxorubicin: A Potential Strategy to Improve the Therapy of Solid Tumors

(2013) K. J. Patel et al.   CLINICAL CANCER RESEARCH

Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients’ bed

(2013) Stefano Ferrari et al.   Journal of Translational Medicine

Use of Molecular Biomarkers to Quantify the Spatial Distribution of Effects of Anticancer Drugs in Solid Tumors

(2013) J. K. Saggar et al.   MOLECULAR CANCER THERAPEUTICS

Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors

(2013) Jai Moo Shin et al.   Journal of Neurogastroenterology and Motility

The Tumor Microenvironment and Strategies to Improve Drug Distribution

(2013) Jasdeep K. Saggar et al.   Frontiers in Oncology

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

A Rationale for the Use of Proton Pump Inhibitors as Antineoplastic Agents

(2012) Angelo De Milito et al.   CURRENT PHARMACEUTICAL DESIGN

Intracellular Proton Pumps as Targets in Chemotherapy: V-ATPases and Cancer

(2012) Agustin Hernandez et al.   CURRENT PHARMACEUTICAL DESIGN

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

(2012) Maria Lucia Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo

(2012) Min Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

(2011) Enrico P Spugnini et al.   Journal of Translational Medicine

Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells

(2011) Andrej Udelnow et al.   PLoS One

Proton pump inhibitor-induced tumour cell death by inhibition of a detoxification mechanism

(2010) S. Fais   JOURNAL OF INTERNAL MEDICINE

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

(2010) M L Marino et al.   Cell Death & Disease

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proton pump inhibitors: an update of their clinical use and pharmacokinetics

(2008) Shaojun Shi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY