Autophagy: Detection, regulation and its role in cancer and therapy response

Beclin 1 bridges autophagy, apoptosis and differentiation

(2014) Jianrong Wang   Autophagy

Angiogenic growth factor axis in autophagy regulation

(2013) Marissa J. Stanton et al.   Autophagy

The use of electron microscopy for the detection of autophagy in human atherosclerosis

(2013) Ida Perrotta   MICRON

Autophagy in Human Health and Disease

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

(2013) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

The Roles of Reactive Oxygen Species and Autophagy in Mediating the Tolerance of Tumor Cells to Cycling Hypoxia

(2013) Marianne Koritzinsky et al.   SEMINARS IN RADIATION ONCOLOGY

Expression and Significance of Microsomal Prostaglandin Synthase-1 (mPGES-1) and Beclin-1 in the Development of Prostate Cancer

(2012) Lu-Wei Xu et al.   Asian Pacific Journal of Cancer Prevention

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Autophagy Control by the VEGF-C/NRP-2 Axis in Cancer and Its Implication for Treatment Resistance

(2012) M. J. Stanton et al.   CANCER RESEARCH

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production

(2012) Claudia Capparelli et al.   CELL CYCLE

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Seeing is believing: The impact of electron microscopy on autophagy research

(2011) Eeva-Liisa Eskelinen et al.   Autophagy

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Sensitizing effect of 3-methyladenine on radiation-induced cytotoxicity in radio-resistant HepG2 cells in vitro and in tumor xenografts

(2011) Hsien-Chun Tseng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas

(2011) Alexandra Giatromanolaki et al.   GYNECOLOGIC ONCOLOGY

The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella

(2011) Shun Kageyama et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy contributes to resistance of tumor cells to ionizing radiation

(2011) Hassan Chaachouay et al.   RADIOTHERAPY AND ONCOLOGY

ATM engages the TSC2/mTORC1 signaling node to regulate autophagy

(2010) Angela Alexander et al.   Autophagy

The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells

(2010) Jiqin Lian et al.   Autophagy

Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy

(2010) Wenzhuo Zhuang et al.   BRAIN RESEARCH

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia

(2010) M I Koukourakis et al.   BRITISH JOURNAL OF CANCER

Methods for detecting autophagy and determining autophagy-induced cell deathThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Yongqiang Chen et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy inhibition contributes to radiation sensitization of esophageal squamous carcinoma cells

(2010) Y. S. Chen et al.   DISEASES OF THE ESOPHAGUS

Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1

(2010) M Djavaheri-Mergny et al.   ONCOGENE

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

(2010) Yushan Zhu et al.   Protein & Cell

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Another way to get rid of fat

(2009) Rudolf Zechner et al.   NATURE

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

Role of apoptosis-regulating signal kinase 1 in innate immune responses by Mycobacterium bovis bacillus Calmette-Guérin

(2008) Jae-Min Yuk et al.   IMMUNOLOGY AND CELL BIOLOGY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

CTLA-4 blockade increases IFN -producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients

(2008) C. I. Liakou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA