Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota

Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis

(2021) Faik Imeri et al.   NEUROPHARMACOLOGY

Role of the PD‐1/PD‐L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions

(2021) Yan Mi et al.   MOLECULAR NEUROBIOLOGY

The second brain: The connection between gut microbiota composition and multiple sclerosis

(2021) Melina Farshbafnadi et al.   JOURNAL OF NEUROIMMUNOLOGY

Advances in oral immunomodulating therapies in relapsing multiple sclerosis

(2020) Tobias Derfuss et al.   LANCET NEUROLOGY

STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination

(2020) Hsueh Chung Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models

(2020) Qian Han et al.   JOURNAL OF NATURAL PRODUCTS

Neurodegenerative diseases and Withania somnifera (L.): An update

(2020) Nawab John Dar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Icariin ameliorates the progression of experimental autoimmune encephalomyelitis by down-regulating the major inflammatory signal pathways in a mouse relapse-remission model of multiple sclerosis

(2020) Hengri Cong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis

(2020) Yan-hong Li et al.   PHARMACOLOGICAL RESEARCH

Interferon β-Mediated Protective Functions of Microglia in Central Nervous System Autoimmunity

(2019) Stefanie Scheu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment of Neurodegenerative Diseases with Bioactive Components of Tripterygium wilfordii

(2019) Jianheng Li et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Reaching an evidence-based prognosis for personalized treatment of multiple sclerosis

(2019) Dalia Rotstein et al.   Nature Reviews Neurology

Severe Exacerbation of Multiple Sclerosis Following Withdrawal of Fingolimod

(2019) Yara D. Fragoso et al.   CLINICAL DRUG INVESTIGATION

Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin

(2019) Evangel Kummari et al.   NEUROIMMUNOMODULATION

A Pilot Microbiota Study in Parkinson’s Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models

(2019) Guadalupe Vidal-Martinez et al.   Journal of Parkinsons Disease

Lymphocyte counts and infection rates

(2019) Edward J. Fox et al.   Neurology-Neuroimmunology & Neuroinflammation

Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling

(2019) Pernille M. Madsen et al.   BRAIN BEHAVIOR AND IMMUNITY

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

(2018) Francesca Cignarella et al.   Cell Metabolism

Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis

(2018) Pei-Yuan Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the Dectin-1 signaling pathway

(2018) Lilin Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives

(2018) Fengna Chu et al.   MEDIATORS OF INFLAMMATION

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis

(2018) Xavier Montalban et al.   Multiple Sclerosis Journal

Multiple Sclerosis: Mechanisms and Immunotherapy

(2018) Clare Baecher-Allan et al.   NEURON

Environmental training is beneficial to clinical symptoms and cortical presynaptic defects in mice suffering from experimental autoimmune encephalomyelitis

(2018) T. Bonfiglio et al.   NEUROPHARMACOLOGY

Multiple Sclerosis

(2018) Raed Alroughani et al.   SEMINARS IN NEUROLOGY

Experimental Autoimmune Encephalomyelitis (EAE) as Animal Models of Multiple Sclerosis (MS)

(2018) Simon Glatigny et al.   Cold Spring Harbor Perspectives in Medicine

The Gut Microbiome and Multiple Sclerosis

(2018) Javier Ochoa-Repáraz et al.   Cold Spring Harbor Perspectives in Medicine

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis

(2018) Xavier Montalban et al.   Multiple Sclerosis Journal

PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state

(2018) Iris Mair et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treatment of multiple sclerosis — success from bench to bedside

(2018) Mar Tintore et al.   Nature Reviews Neurology

Sphingosine 1-Phosphate Receptor Modulators for the Treatment of Multiple Sclerosis

(2017) Burhan Z. Chaudhry et al.   Neurotherapeutics

Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response

(2017) Fanny C. F. Ip et al.   PLoS One

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens

(2017) Kareem R. Rumah et al.   Frontiers in Cellular and Infection Microbiology

Bacillus subtilis Improves Immunity and Disease Resistance in Rabbits

(2017) Mengjiao Guo et al.   Frontiers in Immunology

Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis

(2015) Kris Janssens et al.   Annals of the New York Academy of Sciences

Quality of Reporting and Adherence to ARRIVE Guidelines in Animal Studies for Chagas Disease Preclinical Drug Research: A Systematic Review

(2015) Julián Ernesto Nicolás Gulin et al.   PLoS Neglected Tropical Diseases

Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis

(2014) Laura Garay et al.   JOURNAL OF NEUROIMMUNOLOGY

Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

(2014) Peter A Calabresi et al.   LANCET NEUROLOGY

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

(2013) Christopher S Garris et al.   NATURE IMMUNOLOGY

Development of a novel method for triterpenoidal saponins in rat plasma by solid-phase extraction and high-performance liquid chromatography tandem mass spectrometry

(2011) Huijun Xu et al.   ANALYTICAL BIOCHEMISTRY

23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo

(2010) Yuanting Zheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Regulation of Th1 and Th17 Cell Differentiation and Amelioration of Experimental Autoimmune Encephalomyelitis by Natural Product Compound Berberine

(2010) X. Qin et al.   JOURNAL OF IMMUNOLOGY

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells

(2010) Shahram Lavasani et al.   PLoS One

Methylprednisolone induces reversible clinical and pathological remission and loss of lymphocyte reactivity to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis

(2008) James Chan et al.   AUTOIMMUNITY

FTY720 (fingolimod) for relapsing multiple sclerosis

(2008) Alejandro Horga et al.   Expert Review of Neurotherapeutics

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET