Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors

Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach

(2022) Haytham O. Tawfik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel RNase H Inhibitors Blocking RNA-directed Strand Displacement DNA Synthesis by HIV-1 Reverse Transcriptase

(2022) Samara Martín-Alonso et al.   JOURNAL OF MOLECULAR BIOLOGY

Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond

(2021) Ashley N. Matthew et al.   CHEMICAL REVIEWS

Avoiding Drug Resistance in HIV Reverse Transcriptase

(2021) Maria E. Cilento et al.   CHEMICAL REVIEWS

OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space

(2021) Chao Lu et al.   Journal of Chemical Theory and Computation

Synthesis and Evaluation of Gallotannin Derivatives as Antioxidants and α-Glucosidase Inhibitors

(2021) Shota Machida et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Update and latest advances in antiretroviral therapy

(2021) Luis Menéndez-Arias et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

(2020) Mohamed Fares et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker

(2019) Jing Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus

(2019) Enzo Tramontano et al.   ANTIVIRAL RESEARCH

Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges

(2018) Xueshun Wang et al.   CURRENT MEDICINAL CHEMISTRY

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

(2018) Lei Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Biological Evaluation of Novel Galloyl Derivatives as HIV-1 RNase H Inhibitors

(2018) Ping Gao et al.   Chemical Biology & Drug Design

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

(2017) Sanjeev Kumar V. Vernekar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Viral reverse transcriptases

(2017) Luis Menéndez-Arias et al.   VIRUS RESEARCH

Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H

(2016) Jayakanth Kankanala et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations

(2016) Jing Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current status and prospects of HIV treatment

(2016) Tomas Cihlar et al.   Current Opinion in Virology

Carbonic Anhydrase Inhibitors with Dual-Tail Moieties To Match the Hydrophobic and Hydrophilic Halves of the Carbonic Anhydrase Active Site

(2015) Rajendra P. Tanpure et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

(2015) Peng Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Progress in the Research of Small Molecule HIV-1 RNase H Inhibitors

(2014) Lili Cao et al.   CURRENT MEDICINAL CHEMISTRY

Pyridopyrimidinone inhibitors of HIV-1 RNase H

(2014) Emile J. Velthuisen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation

(2014) Greg L. Beilhartz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

(2014) Sanjeev Kumar V. Vernekar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs

(2014) Daniel M. Himmel et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis of human immunodeficiency virus type 1 drug resistance: Overview and recent developments

(2013) Luis Menéndez-Arias   ANTIVIRAL RESEARCH

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A Novel Semisynthetic Flavonoid 7-O-Galloyltaxifolin Upregulates Heme Oxygenase-1 in RAW264.7 Cells via MAPK/Nrf2 Pathway

(2013) Jiří Vrba et al.   JOURNAL OF MEDICINAL CHEMISTRY

Past, present and future: 30 years of HIV research

(2013) Françoise Barré-Sinoussi et al.   NATURE REVIEWS MICROBIOLOGY

HIV-1 Reverse Transcription

(2013) W.-S. Hu et al.   Cold Spring Harbor Perspectives in Medicine

Hypericum hircinumL. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities

(2013) Francesca Esposito et al.   Pathogens and Disease

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid andN-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

(2011) Eric B. Lansdon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diketo Acids Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain

(2011) R. Di Santo   CURRENT MEDICINAL CHEMISTRY

Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold

(2010) Peter D. Williams et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors

(2010) Greg L. Beilhartz et al.   Viruses-Basel

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

(2009) Marie-Pierre de Béthune   ANTIVIRAL RESEARCH

Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

(2009) Tomas Cihlar et al.   ANTIVIRAL RESEARCH

Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

(2009) Thomas Ryckmans et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information

(2009) Thorsten A. Kirschberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased Thermostability and Fidelity of DNA Synthesis of Wild-Type and Mutant HIV-1 Group O Reverse Transcriptases

(2009) Mar Álvarez et al.   JOURNAL OF MOLECULAR BIOLOGY

Green tea polyphenols for prostate cancer chemoprevention: A translational perspective

(2009) J.J. Johnson et al.   PHYTOMEDICINE

Enhanced anti-influenza A virus activity of (−)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: Effect of alkyl chain length

(2008) Shuichi Mori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

(2008) Stefan G. Sarafianos et al.   JOURNAL OF MOLECULAR BIOLOGY

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols