Novel RNase H Inhibitors Blocking RNA-directed Strand Displacement DNA Synthesis by HIV-1 Reverse Transcriptase
Published 2022 View Full Article
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Title
Novel RNase H Inhibitors Blocking RNA-directed Strand Displacement DNA Synthesis by HIV-1 Reverse Transcriptase
Authors
Keywords
reverse transcriptase, HIV, RNase H, RNase H inhibitors, strand displacement
Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 434, Issue 7, Pages 167507
Publisher
Elsevier BV
Online
2022-02-23
DOI
10.1016/j.jmb.2022.167507
References
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Note: Only part of the references are listed.- Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction
- (2021) Mar Álvarez et al. Viruses-Basel
- Small-molecule Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H function: Challenges and Recent Developments.
- (2021) Valentina Noemi Madia et al. CURRENT MEDICINAL CHEMISTRY
- Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase
- (2021) Antonella Messore et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors
- (2021) Dongwei Kang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Defective strand-displacement DNA synthesis due to accumulation of thymidine analogue resistance mutations in HIV-2 reverse transcriptase
- (2020) Samara Martín-Alonso et al. ACS Infectious Diseases
- DNA Strand Displacement Reaction: A Powerful Tool for Discriminating Single Nucleotide Variants
- (2020) Weiyang Tang et al. Topics in Current Chemistry
- Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance
- (2020) Francesc Xavier RUIZ et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Reverse Transcriptase: From Transcriptomics to Genome Editing
- (2020) Samara Martín-Alonso et al. TRENDS IN BIOTECHNOLOGY
- UCSF ChimeraX : Structure visualization for researchers, educators, and developers
- (2020) Eric F. Pettersen et al. PROTEIN SCIENCE
- Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C
- (2020) Ping Gao et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Testing of library preparation methods for transcriptome sequencing of real life glioblastoma and brain tissue specimens: A comparative study with special focus on long non-coding RNAs
- (2019) Marek Vecera et al. PLoS One
- Principles and Applications of Nucleic Acid Strand Displacement Reactions
- (2019) Friedrich C. Simmel et al. CHEMICAL REVIEWS
- An emergent understanding of strand displacement in RNA biology
- (2019) Fan Hong et al. JOURNAL OF STRUCTURAL BIOLOGY
- Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus
- (2019) Enzo Tramontano et al. ANTIVIRAL RESEARCH
- Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase
- (2019) Ping Gao et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges
- (2018) Xueshun Wang et al. CURRENT MEDICINAL CHEMISTRY
- 5-Hydroxypyrido[2,3- b ]pyrazin-6(5 H )-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
- (2018) Lin Sun et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Template-primer binding affinity and RNase H cleavage specificity contribute to the strand transfer efficiency of HIV-1 reverse transcriptase
- (2018) Joanna Luczkowiak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid
- (2018) Lan Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Design, Synthesis and Biological Evaluation of Novel Galloyl Derivatives as HIV-1 RNase H Inhibitors
- (2018) Ping Gao et al. Chemical Biology & Drug Design
- Effective design principles for leakless strand displacement systems
- (2018) Boya Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H
- (2017) Jayakanth Kankanala et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Comparative Analysis of Single-Cell RNA Sequencing Methods
- (2017) Christoph Ziegenhain et al. MOLECULAR CELL
- Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase
- (2017) Omri Malik et al. NUCLEIC ACIDS RESEARCH
- Viral reverse transcriptases
- (2017) Luis Menéndez-Arias et al. VIRUS RESEARCH
- HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently
- (2016) An Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6
- (2016) Angela Corona et al. PLoS One
- Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis
- (2015) Gilberto Betancor et al. NUCLEIC ACIDS RESEARCH
- Inhibitors of Nucleotidyltransferase Superfamily Enzymes Suppress Herpes Simplex Virus Replication
- (2014) John E. Tavis et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Library preparation methods for next-generation sequencing: Tone down the bias
- (2014) Erwin L. van Dijk et al. EXPERIMENTAL CELL RESEARCH
- Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs
- (2014) Daniel M. Himmel et al. JOURNAL OF MOLECULAR BIOLOGY
- β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity
- (2013) Yuan Hu et al. ANTIVIRAL RESEARCH
- Major Groove Binding Track Residues of the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Enhance cDNA Synthesis at High Temperatures
- (2013) Tania Matamoros et al. BIOCHEMISTRY
- Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis
- (2013) Mar Álvarez et al. NUCLEIC ACIDS RESEARCH
- The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus
- (2011) Yue-Lei Chen et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A376S in the Connection Subdomain of HIV-1 Reverse Transcriptase Confers Increased Risk of Virological Failure to Nevirapine Therapy
- (2011) Roger Paredes et al. JOURNAL OF INFECTIOUS DISEASES
- HIV-1 Reverse Transcriptase Dissociates during Strand Transfer
- (2011) John M. Muchiri et al. JOURNAL OF MOLECULAR BIOLOGY
- SwissDock, a protein-small molecule docking web service based on EADock DSS
- (2011) A. Grosdidier et al. NUCLEIC ACIDS RESEARCH
- Mechanisms Involved in the Selection of HIV-1 Reverse Transcriptase Thumb Subdomain Polymorphisms Associated with Nucleoside Analogue Therapy Failure
- (2010) G. Betancor et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Thymidine Analogue Resistance Suppression by V75I of HIV-1 Reverse Transcriptase
- (2009) Tania Matamoros et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased Thermostability and Fidelity of DNA Synthesis of Wild-Type and Mutant HIV-1 Group O Reverse Transcriptases
- (2009) Mar Álvarez et al. JOURNAL OF MOLECULAR BIOLOGY
- HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition
- (2009) Greg L. Beilhartz et al. JOURNAL OF MOLECULAR BIOLOGY
- Single-Molecule Study of DNA Polymerization Activity of HIV-1 Reverse Transcriptase on DNA Templates
- (2009) Sangjin Kim et al. JOURNAL OF MOLECULAR BIOLOGY
- Murine leukemia virus reverse transcriptase: Structural comparison with HIV-1 reverse transcriptase
- (2008) Marie L. Coté et al. VIRUS RESEARCH
- Strand transfer events during HIV-1 reverse transcription
- (2008) Vandana Purohit Basu et al. VIRUS RESEARCH
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