Deficient mismatch repair/microsatellite unstable colorectal cancer: Diagnosis, prognosis and treatment
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Title
Deficient mismatch repair/microsatellite unstable colorectal cancer: Diagnosis, prognosis and treatment
Authors
Keywords
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Journal
EUROPEAN JOURNAL OF CANCER
Volume 175, Issue -, Pages 136-157
Publisher
Elsevier BV
Online
2022-09-14
DOI
10.1016/j.ejca.2022.07.020
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Note: Only part of the references are listed.- Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers
- (2022) Giovanni Fucà et al. Journal for ImmunoTherapy of Cancer
- Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study
- (2022) Luis A Diaz et al. LANCET ONCOLOGY
- Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142
- (2022) T. André et al. ANNALS OF ONCOLOGY
- PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer
- (2022) Andrea Cercek et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and efficacy of anti–PD-1 antibody dostarlimab in patients (pts) with mismatch repair-deficient (dMMR) solid cancers: Results from GARNET study.
- (2021) Thierry Andre et al. JOURNAL OF CLINICAL ONCOLOGY
- Subgroup analyses of patients (pts) with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC) treated with nivolumab (NIVO) plus low-dose ipilimumab (IPI) as first-line (1L) therapy:Two-year clinical update.
- (2021) Heinz-Josef Lenz et al. JOURNAL OF CLINICAL ONCOLOGY
- Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer
- (2021) Romain Cohen et al. Journal for ImmunoTherapy of Cancer
- Pembrolizumab Plus Ipilimumab Following Anti-PD-1/L1 Failure in Melanoma
- (2021) Daniel J. Olson et al. JOURNAL OF CLINICAL ONCOLOGY
- Health-related quality of life in patients with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer treated with first-line pembrolizumab versus chemotherapy (KEYNOTE-177): an open-label, randomised, phase 3 trial
- (2021) Thierry Andre et al. LANCET ONCOLOGY
- The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors
- (2021) Benoit Rousseau et al. NEW ENGLAND JOURNAL OF MEDICINE
- 1758O Neoadjuvant pembrolizumab in localized/locally advanced solid tumors with mismatch repair deficiency
- (2021) K. Ludford et al. ANNALS OF ONCOLOGY
- Randomized study to investigate FOLFOXIRI plus either bevacizumab or cetuximab as first-line treatment of BRAF V600E-mutant mCRC: The phase-II FIRE-4.5 study (AIO KRK-0116).
- (2021) Sebastian Stintzing et al. JOURNAL OF CLINICAL ONCOLOGY
- Efficacy of nivolumab/ipilimumab in patients with initial or late progression with nivolumab: Updated analysis of a tailored approach in advanced renal cell carcinoma (TITAN-RCC).
- (2021) Marc-Oliver Grimm et al. JOURNAL OF CLINICAL ONCOLOGY
- Artificial Intelligence Can Cut Costs While Maintaining Accuracy in Colorectal Cancer Genotyping
- (2021) Alec J. Kacew et al. Frontiers in Oncology
- Prediction of Benefit from Checkpoint Inhibitors in Mismatch Repair Deficient Metastatic Colorectal Cancer: Role of Tumor Infiltrating Lymphocytes
- (2020) Fotios Loupakis et al. ONCOLOGIST
- Detection of Microsatellite Instability from Circulating Tumor DNA by Targeted Deep Sequencing
- (2020) Zhenghao Cai et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
- (2020) Myriam Chalabi et al. NATURE MEDICINE
- Localised Colon Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up
- (2020) G. Argiles et al. ANNALS OF ONCOLOGY
- Clinical-grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning
- (2020) Amelie Echle et al. GASTROENTEROLOGY
- Salvage Ipilimumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma After Prior Immune Checkpoint Inhibitors
- (2020) Anita Gul et al. JOURNAL OF CLINICAL ONCOLOGY
- Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA
- (2020) Adrien Pécriaux et al. JOURNAL OF CLINICAL PATHOLOGY
- Individual Patient Data Meta-Analysis of FOLFOXIRI Plus Bevacizumab Versus Doublets Plus Bevacizumab as Initial Therapy of Unresectable Metastatic Colorectal Cancer
- (2020) Chiara Cremolini et al. JOURNAL OF CLINICAL ONCOLOGY
- The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
- (2020) Alexej Ballhausen et al. Nature Communications
- The Landmark Series: Chemotherapy for Non-Metastatic Colon Cancer
- (2020) Salvador Alonso et al. ANNALS OF SURGICAL ONCOLOGY
- Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials
- (2020) Thierry André et al. LANCET ONCOLOGY
- Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
- (2020) Thierry André et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prognostic variables in low and high risk stage III colon cancers treated in two adjuvant chemotherapy trials
- (2020) Frank A. Sinicrope et al. EUROPEAN JOURNAL OF CANCER
- Pseudoprogression in patients treated with immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer
- (2020) Raphael Colle et al. EUROPEAN JOURNAL OF CANCER
- Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome
- (2019) Federico Innocenti et al. JOURNAL OF CLINICAL ONCOLOGY
- MSI/MMR-deficient tumor diagnosis: Which standard for screening and for diagnosis? Diagnostic modalities for the colon and other sites: Differences between tumors
- (2019) Magali Svrcek et al. BULLETIN DU CANCER
- Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer
- (2019) A B Schrock et al. ANNALS OF ONCOLOGY
- ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach
- (2019) C Luchini et al. ANNALS OF ONCOLOGY
- Refining adjuvant therapy for non-metastatic colon cancer, new standards and perspectives
- (2019) Julien Taieb et al. CANCER TREATMENT REVIEWS
- Phase I dose-escalation of trifluridine/tipiracil in combination with oxaliplatin in patients with metastatic colorectal cancer
- (2019) Guillem Argilés et al. EUROPEAN JOURNAL OF CANCER
- Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response
- (2019) Rajarsi Mandal et al. SCIENCE
- Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an ACCENT pooled analysis of seven studies
- (2019) J Taieb et al. ANNALS OF ONCOLOGY
- Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium
- (2019) Rodabe N Amaria et al. LANCET ONCOLOGY
- Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer
- (2019) Jakob Nikolas Kather et al. NATURE MEDICINE
- Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade
- (2019) Andrew Georgiadis et al. CLINICAL CANCER RESEARCH
- The Crohn's-Like Lymphoid Reaction to Colorectal Cancer-Tertiary Lymphoid Structures With Immunologic and Potentially Therapeutic Relevance in Colorectal Cancer
- (2019) Asaf Maoz et al. Frontiers in Immunology
- High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants
- (2019) Pedram Razavi et al. NATURE MEDICINE
- Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer
- (2019) Evrard et al. Cancers
- Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes
- (2019) Jaclyn F. Hechtman et al. MODERN PATHOLOGY
- Improved Microsatellite Instability Detection and Identification by Nuclease-Assisted Microsatellite Instability Enrichment Using HSP110 T17
- (2018) Laura G. Baudrin et al. CLINICAL CHEMISTRY
- Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer
- (2018) Michael J. Overman et al. JOURNAL OF CLINICAL ONCOLOGY
- Two-stain immunohistochemical screening for Lynch syndrome in colorectal cancer may fail to detect mismatch repair deficiency
- (2018) Rachel Pearlman et al. MODERN PATHOLOGY
- Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
- (2018) Patrick M. Forde et al. NEW ENGLAND JOURNAL OF MEDICINE
- Advantage of HSP110 (T17) marker inclusion for microsatellite instability (MSI) detection in colorectal cancer patients
- (2018) Gustavo Noriz Berardinelli et al. Oncotarget
- Association Between Circulating Tumor DNA and Pseudoprogression in Patients With Metastatic Melanoma Treated With Anti–Programmed Cell Death 1 Antibodies
- (2018) Jenny H. Lee et al. JAMA Oncology
- Mismatch Repair Deficiency Testing in Patients With Colorectal Cancer and Nonadherence to Testing Guidelines in Young Adults
- (2018) Talha Shaikh et al. JAMA Oncology
- Assessment of Tumor Sequencing as a Replacement for Lynch Syndrome Screening and Current Molecular Tests for Patients With Colorectal Cancer
- (2018) Heather Hampel et al. JAMA Oncology
- Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status
- (2018) Romain Cohen et al. JAMA Oncology
- Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas
- (2017) Mark Clendenning et al. Familial Cancer
- Major improvement in the detection of microsatellite instability in colorectal cancer using HSP110 T17 E-ice -COLD-PCR
- (2017) Alexandre How-Kit et al. HUMAN MUTATION
- Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
- (2017) Michael J Overman et al. LANCET ONCOLOGY
- iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics
- (2017) Lesley Seymour et al. LANCET ONCOLOGY
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- Resistance to checkpoint blockade therapy through inactivation of antigen presentation
- (2017) Moshe Sade-Feldman et al. Nature Communications
- A Practical Approach to the Evaluation of Gastrointestinal Tract Carcinomas for Lynch Syndrome
- (2016) Rish K. Pai et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability
- (2016) Bernhard Mlecnik et al. IMMUNITY
- Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels
- (2016) Zsofia K. Stadler et al. JOURNAL OF CLINICAL ONCOLOGY
- HSP110T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer
- (2016) Olivier Buhard et al. JOURNAL OF MEDICAL GENETICS
- Efficacy of Adjuvant Chemotherapy in Colon Cancer With Microsatellite Instability: A Large Multicenter AGEO Study
- (2016) David Tougeron et al. JNCI-Journal of the National Cancer Institute
- STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration
- (2016) Jérémie F Cohen et al. BMJ Open
- Efficacy of Adjuvant Chemotherapy in Colon Cancer With Microsatellite Instability: A Large Multicenter AGEO Study
- (2016) David Tougeron et al. JNCI-Journal of the National Cancer Institute
- Prognostic Effect ofBRAFandKRASMutations in Patients With Stage III Colon Cancer Treated With Leucovorin, Fluorouracil, and Oxaliplatin With or Without Cetuximab
- (2016) Julien Taieb et al. JAMA Oncology
- Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According toBRAFMutation and Mismatch Repair Status of the MOSAIC Study
- (2015) Thierry André et al. JOURNAL OF CLINICAL ONCOLOGY
- Constitutional mismatch repair deficiency syndrome: clinical description in a French cohort
- (2015) N Lavoine et al. JOURNAL OF MEDICAL GENETICS
- FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study
- (2015) Chiara Cremolini et al. LANCET ONCOLOGY
- The consensus molecular subtypes of colorectal cancer
- (2015) Justin Guinney et al. NATURE MEDICINE
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
- (2014) S. Venderbosch et al. CLINICAL CANCER RESEARCH
- MSIsensor: microsatellite instability detection using paired tumor-normal sequence data
- (2013) Beifang Niu et al. BIOINFORMATICS
- Somatic Mutations in MLH1 and MSH2 Are a Frequent Cause of Mismatch-Repair Deficiency in Lynch Syndrome-Like Tumors
- (2013) Arjen R. Mensenkamp et al. GASTROENTEROLOGY
- Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
- (2013) Hans F A Vasen et al. GUT
- Mutation Profiling and Microsatellite Instability in Stage II and III Colon Cancer: An Assessment of Their Prognostic and Oxaliplatin Predictive Value
- (2012) P. G. Gavin et al. CLINICAL CANCER RESEARCH
- Somatic mosaicism and double somatic hits can lead to MSI colorectal tumors
- (2012) Isabelle Sourrouille et al. Familial Cancer
- Correlation of tumour BRAF mutations andMLH1methylation with germline mismatch repair (MMR) gene mutation status: a literature review assessing utility of tumour features for MMR variant classification
- (2012) Michael T Parsons et al. JOURNAL OF MEDICAL GENETICS
- Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer
- (2011) Gordon Hutchins et al. JOURNAL OF CLINICAL ONCOLOGY
- DNA Mismatch Repair Status and Colon Cancer Recurrence and Survival in Clinical Trials of 5-Fluorouracil-Based Adjuvant Therapy
- (2011) F. A. Sinicrope et al. JNCI-Journal of the National Cancer Institute
- Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis
- (2011) Coralie Dorard et al. NATURE MEDICINE
- Microsatellite Instability in Colorectal Cancer
- (2010) C. Richard Boland et al. GASTROENTEROLOGY
- Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer
- (2010) Daniel J. Sargent et al. JOURNAL OF CLINICAL ONCOLOGY
- Microsatellite instability in colorectal cancer—the stable evidence
- (2010) Eduardo Vilar et al. Nature Reviews Clinical Oncology
- Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis
- (2010) Bernd Timmermann et al. PLoS One
- Interpretation of Immunohistochemistry for Mismatch Repair Proteins is Only Reliable in a Specialized Setting
- (2009) Lucia I. H. Overbeek et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Immunohistochemistry as First-line Screening for Detecting Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome
- (2009) Jinru Shia et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Immunohistochemistry versus Microsatellite Instability Testing for Screening Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome
- (2008) Liying Zhang JOURNAL OF MOLECULAR DIAGNOSTICS
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