ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach

Gastric Carcinomas With Lymphoid Stroma

(2018) Erika Hissong et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer

(2018) Russell W. Jenkins et al.   Annual Review of Medicine

Colorectal Carcinomas With Isolated Loss of PMS2 Staining by Immunohistochemistry

(2018) Lindsay Alpert et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Tumor mutational burden analysis of 2,000 Japanese cancer genomes using whole exome and targeted gene panel sequencing

(2018) Keiichi HATAKEYAMA et al.   BIOMEDICAL RESEARCH-TOKYO

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

(2018) Matthew D. Hellmann et al.   CANCER CELL

Comprehensive analysis of cancers of unknown primary for the biomarkers of response to immune checkpoint blockade therapy

(2018) Zoran Gatalica et al.   EUROPEAN JOURNAL OF CANCER

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

(2018) Kristian M. Hargadon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer

(2018) Michael J. Overman et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Determinants of Response to Anti–Programmed Cell Death (PD)-1 and Anti–Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non–Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing

(2018) Hira Rizvi et al.   JOURNAL OF CLINICAL ONCOLOGY

Two-stain immunohistochemical screening for Lynch syndrome in colorectal cancer may fail to detect mismatch repair deficiency

(2018) Rachel Pearlman et al.   MODERN PATHOLOGY

Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers

(2018) Mohamed E. Salem et al.   MOLECULAR CANCER RESEARCH

Tumor Mutational Burden Guides Therapy in a Treatment RefractoryPOLE‐Mutant Uterine Carcinosarcoma

(2018) Munveer S. Bhangoo et al.   ONCOLOGIST

DNA mismatch repair in cancer

(2018) Marina Baretti et al.   PHARMACOLOGY & THERAPEUTICS

New therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles

(2018) Takahiro Nakagomi et al.   Oncotarget

Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients

(2018) Ari Vanderwalde et al.   Cancer Medicine

Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors

(2018) Aaron M. Goodman et al.   JAMA Oncology

Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer

(2018) Charles S. Fuchs et al.   JAMA Oncology

An Update on Immunotherapy for Solid Tumors: A Review

(2018) Toan Pham et al.   ANNALS OF SURGICAL ONCOLOGY

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

(2018) Jennifer Ma et al.   Nature Communications

Association of MUC16 Mutation With Tumor Mutation Load and Outcomes in Patients With Gastric Cancer

(2018) Xiangchun Li et al.   JAMA Oncology

Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro

(2017) Stefania Bellone et al.   GYNECOLOGIC ONCOLOGY

Genomic profiling of squamous malignancies across anatomic sites.

(2017) Christine H. Chung et al.   JOURNAL OF CLINICAL ONCOLOGY

Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next-Generation Sequencing

(2017) Jonathan A. Nowak et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma

(2017) Claudio Luchini et al.   JOURNAL OF PATHOLOGY

Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer

(2017) Anshuman Panda et al.   JNCI-Journal of the National Cancer Institute

Response to PD-1 Blockade in Microsatellite Stable Metastatic Colorectal Cancer Harboring aPOLEMutation

(2017) Jun Gong et al.   Journal of the National Comprehensive Cancer Network

Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology

(2017) Al B. Benson et al.   Journal of the National Comprehensive Cancer Network

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

(2017) Michael J Overman et al.   LANCET ONCOLOGY

Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy

(2017) Tiffany R. Hodges et al.   NEURO-ONCOLOGY

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer

(2017) Yelena Y. Janjigian et al.   Cancer Discovery

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

(2017) Zachary R. Chalmers et al.   Genome Medicine

Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer

(2017) Anshuman Panda et al.   JNCI-Journal of the National Cancer Institute

Cervical Cancer Neoantigen Landscape and Immune Activity is Associated with Human Papillomavirus Master Regulators

(2017) Yong Qin et al.   Frontiers in Immunology

High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations

(2017) Amélie Boichard et al.   OncoImmunology

Microsatellite Instability as a Biomarker for PD-1 Blockade

(2016) J. C. Dudley et al.   CLINICAL CANCER RESEARCH

Cancer predisposition syndromes: lessons for truly precision medicine

(2016) Mark A Glaire et al.   JOURNAL OF PATHOLOGY

Classification and characterization of microsatellite instability across 18 cancer types

(2016) Ronald J Hause et al.   NATURE MEDICINE

Strategies for clinical implementation of screening for hereditary cancer syndromes

(2016) Brandie Heald et al.   SEMINARS IN ONCOLOGY

A meta-analysis of MSI frequency and race in colorectal cancer

(2016) Hassan Ashktorab et al.   Oncotarget

Deficient mismatch repair: Read all about it (Review)

(2015) SUSAN RICHMAN   INTERNATIONAL JOURNAL OF ONCOLOGY

Hereditary Colorectal Cancer Syndromes: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the Familial Risk–Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guidelines

(2015) Elena M. Stoffel et al.   JOURNAL OF CLINICAL ONCOLOGY

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention

(2015) Maria-Pia Bernardi et al.   LANCET ONCOLOGY

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

(2015) Razvan Cristescu et al.   NATURE MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of Polymerase e–Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1

(2015) Brooke E. Howitt et al.   JAMA Oncology

Microsatellite Instability Detection by Next Generation Sequencing

(2014) S. J. Salipante et al.   CLINICAL CHEMISTRY

Muir–Torre syndrome or phenocopy? The value of the immunohistochemical expression of mismatch repair proteins in sebaceous tumors of immunocompromised patients

(2014) G. Ponti et al.   Familial Cancer

Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium “Care for CMMR-D” (C4CMMR-D)

(2014) H F A Vasen et al.   JOURNAL OF MEDICAL GENETICS

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

MSIsensor: microsatellite instability detection using paired tumor-normal sequence data

(2013) Beifang Niu et al.   BIOINFORMATICS

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes

(2013) Tae-Min Kim et al.   CELL

Mismatch repair status and clinical outcome in endometrial cancer: A systematic review and meta-analysis

(2013) Ivan Diaz-Padilla et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update

(2013) M.J. Duffy et al.   INTERNATIONAL JOURNAL OF CANCER

Implementation of Universal Microsatellite Instability and Immunohistochemistry Screening for Diagnosing Lynch Syndrome in a Large Academic Medical Center

(2013) Brandie Heald et al.   JOURNAL OF CLINICAL ONCOLOGY

Postreplicative Mismatch Repair

(2013) J. Jiricny   Cold Spring Harbor Perspectives in Biology

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

(2012) Ramaswamy Govindan et al.   CELL

Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM)

(2012) Pilar García-Alfonso et al.   Clinical & Translational Oncology

Report From the Jerusalem Workshop on Lynch Syndrome-Hereditary Nonpolyposis Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

Constitutional mismatch repair-deficiency syndrome

(2010) K. Wimmer et al.   HAEMATOLOGICA

Frequency of mismatch repair deficiency in ovarian cancer: a systematic review This article is a US Government work and, as such, is in the public domain of the United States of America.

(2010) Megan A. Murphy et al.   INTERNATIONAL JOURNAL OF CANCER

An Optimized Pentaplex PCR for Detecting DNA Mismatch Repair-Deficient Colorectal Cancers

(2010) Ajay Goel et al.   PLoS One

Systematic Review and Meta-analysis of Ovarian Cancers: Estimation of Microsatellite-High Frequency and Characterization of Mismatch Repair Deficient Tumor Histology

(2008) T. Pal et al.   CLINICAL CANCER RESEARCH

Immunohistochemistry versus Microsatellite Instability Testing For Screening Colorectal Cancer Patients at Risk For Hereditary Nonpolyposis Colorectal Cancer Syndrome

(2008) Jinru Shia   JOURNAL OF MOLECULAR DIAGNOSTICS

Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

(2008) Marjolijn J L Ligtenberg et al.   NATURE GENETICS