Two-stain immunohistochemical screening for Lynch syndrome in colorectal cancer may fail to detect mismatch repair deficiency

Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer

(2017) Rachel Pearlman et al.   JAMA Oncology

Heterogenous MSH6 Loss Is a Result of Microsatellite Instability Within MSH6 and Occurs in Sporadic and Hereditary Colorectal and Endometrial Carcinomas

(2015) Rondell P. Graham et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Detection of Microsatellite Instability in Early Colorectal Lesions

(2015) Jeffery W. Bacher et al.   PLoS One

Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

(2014) Francis M Giardiello et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Colon and Endometrial Cancers With Mismatch Repair Deficiency Can Arise From Somatic, Rather Than Germline, Mutations

(2014) Sigurdis Haraldsdottir et al.   GASTROENTEROLOGY

How reliable is immunohistochemical staining for DNA mismatch repair proteins performed after neoadjuvant chemoradiation?

(2014) Alex Vilkin et al.   HUMAN PATHOLOGY

Somatic aberrations of mismatch repair genes as a cause of microsatellite-unstable cancers

(2014) Willemina RR Geurts-Giele et al.   JOURNAL OF PATHOLOGY

Somatic Mutations in MLH1 and MSH2 Are a Frequent Cause of Mismatch-Repair Deficiency in Lynch Syndrome-Like Tumors

(2013) Arjen R. Mensenkamp et al.   GASTROENTEROLOGY

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

(2013) Hans F A Vasen et al.   GUT

Microsatellite Instability and DNA Mismatch Repair Protein Deficiency in Lynch Syndrome Colorectal Polyps

(2012) M. B. Yurgelun et al.   Cancer Prevention Research

Somatic mosaicism and double somatic hits can lead to MSI colorectal tumors

(2012) Isabelle Sourrouille et al.   Familial Cancer

Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients

(2012) Jukka Kantelinen et al.   HUMAN MUTATION

ColoSeq Provides Comprehensive Lynch and Polyposis Syndrome Mutational Analysis Using Massively Parallel Sequencing

(2012) Colin C. Pritchard et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: a case series from the Australasian site of the colon cancer family registry

(2012) Michael D Walsh et al.   MODERN PATHOLOGY

Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency

(2012) Jinru Shia et al.   MODERN PATHOLOGY

Challenging cases encountered in colorectal cancer screening for Lynch syndrome reveal novel findings: nucleolar MSH6 staining and impact of prior chemoradiation therapy

(2011) Oana M. Radu et al.   HUMAN PATHOLOGY

A two-antibody mismatch repair protein immunohistochemistry screening approach for colorectal carcinomas, skin sebaceous tumors and gynecologic tract carcinomas

(2011) Amirkaveh Mojtahed et al.   MODERN PATHOLOGY

Neoadjuvant Therapy Induces Loss of MSH6 Expression in Colorectal Carcinoma

(2010) Fei Bao et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Immunohistochemistry for PMS2 and MSH6 alone can replace a four antibody panel for mismatch repair deficiency screening in colorectal adenocarcinoma

(2010) Geoffrey Hall et al.   PATHOLOGY

EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome

(2009) Glenn E Palomaki et al.   GENETICS IN MEDICINE

Feasibility of Screening for Lynch Syndrome Among Patients With Colorectal Cancer

(2008) Heather Hampel et al.   JOURNAL OF CLINICAL ONCOLOGY