The search for optimal antithrombotic therapy in transcatheter aortic valve implantation: facts and uncertainties

Edoxaban versus Dual Antiplatelet Therapy for Leaflet Thrombosis and Cerebral Thromboembolism after TAVR: The ADAPT-TAVR Randomized Clinical Trial

(2022) Duk-Woo Park et al.   CIRCULATION

Clinical Impact of Hypoattenuating Leaflet Thickening After Transcatheter Aortic Valve Replacement

(2022) Santiago Garcia et al.   Circulation-Cardiovascular Interventions

Apixaban vs. standard of care after transcatheter aortic valve implantation: the ATLANTIS trial

(2022) Jean-Philippe Collet et al.   EUROPEAN HEART JOURNAL

Aspirin Versus Clopidogrel as Single Antithrombotic Therapy After Transcatheter Aortic Valve Replacement: Insight From the OCEAN-TAVI Registry

(2021) Yusuke Kobari et al.   Circulation-Cardiovascular Interventions

A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial

(2021) Alexandra J Lansky et al.   EUROPEAN HEART JOURNAL

Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart Disease

(2021) Jurrien ten Berg et al.   EUROPEAN HEART JOURNAL

Aspirin Alone Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Implantation: A Systematic Review and Patient‐Level Meta‐Analysis

(2021) Jorn Brouwer et al.   Journal of the American Heart Association

Duration of Antiplatelet Therapy Following Transcatheter Aortic Valve Replacement: Systematic Review and Network Meta‐Analysis

(2021) Toshiki Kuno et al.   Journal of the American Heart Association

Comparison of Ticagrelor Versus Clopidogrel on Cerebrovascular Microembolic Events and Platelet Inhibition during Transcatheter Aortic Valve Implantation

(2021) Michael A. Vavuranakis et al.   AMERICAN JOURNAL OF CARDIOLOGY

2021 ESC/EACTS Guidelines for the management of valvular heart disease

(2021) Alec Vahanian et al.   EUROPEAN HEART JOURNAL

TAVR Patients Requiring Anticoagulation

(2021) Romain Didier et al.   JACC-Cardiovascular Interventions

Assessment of the Academic Research Consortium for High Bleeding Risk Criteria in Patients Undergoing TAVR

(2021) Willem L. Bor et al.   JACC-Cardiovascular Interventions

Antithrombotic Therapy After Transcatheter Aortic Valve Replacement

(2021) Davide Capodanno et al.   JACC-Cardiovascular Interventions

Development and Validation of a Practical Model to Identify Patients at Risk of Bleeding After TAVR

(2021) Eliano Pio Navarese et al.   JACC-Cardiovascular Interventions

Factor XI Inhibition to Uncouple Thrombosis From Hemostasis

(2021) Charles Hsu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR

(2021) Nicolas M. Van Mieghem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual Antiplatelet Therapy vs. Single Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: An Updated Systematic Review and Meta-Analysis

(2021) Yipeng Zhang et al.   Frontiers in Cardiovascular Medicine

Subclinical Leaflet Thrombosis After Transcatheter Aortic Valve Replacement

(2021) Matthias Bogyi et al.   JACC-Cardiovascular Interventions

Neosinus and Sinus Flow After Self-Expanding and Balloon-Expandable Transcatheter Aortic Valve Replacement

(2021) Hoda Hatoum et al.   JACC-Cardiovascular Interventions

Leaflet Thickening or Immobility Following Aortic Valve Replacement: Results from the Evolut Low Risk Sub-study

(2020) Philipp Blanke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial

(2020) Marieke Gimbel et al.   LANCET

Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation

(2020) Vincent J. Nijenhuis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Routine Ultrasound or Fluoroscopy Use and Risk of Vascular/Bleeding Complications After Transfemoral TAVR

(2020) Guy Witberg et al.   JACC-Cardiovascular Interventions

Safety and Efficacy of Protamine Administration for Prevention of Bleeding Complications in Patients Undergoing TAVR

(2020) Baravan Al-Kassou et al.   JACC-Cardiovascular Interventions

Subclinical Leaflet Thrombosis in Transcatheter and Surgical Bioprosthetic Valves

(2020) Raj R. Makkar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparing anticoagulation therapy alone versus anticoagulation plus single antiplatelet drug therapy after transcatheter aortic valve implantation in patients with an indication for anticoagulation: a systematic review and meta-analysis

(2020) Yong Zhu et al.   CARDIOVASCULAR DRUGS AND THERAPY

Comparison Between Ticagrelor and Clopidogrel in Elderly Patients with an Acute Coronary Syndrome: Insights from the SWEDEHEART Registry

(2020) Karolina Szummer et al.   CIRCULATION

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)

(2020) Gerhard Hindricks et al.   EUROPEAN HEART JOURNAL

Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation

(2020) Jorn Brouwer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bleeding Complications Drive In-Hospital Mortality of Patients with Atrial Fibrillation after Transcatheter Aortic Valve Replacement

(2020) Achim Lother et al.   THROMBOSIS AND HAEMOSTASIS

2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

(2020) Catherine M. Otto et al.   CIRCULATION

Safety and Efficacy of Transcatheter Aortic Valve Replacement With Continuation of Vitamin K Antagonists or Direct Oral Anticoagulants

(2020) Miriam Brinkert et al.   JACC-Cardiovascular Interventions

Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research

(2020) et al.   EUROPEAN HEART JOURNAL

Assessment of Platelet REACtivity After Transcatheter Aortic Valve Replacement

(2019) Victor Alfonso Jimenez Diaz et al.   JACC-Cardiovascular Interventions

Blood Disorders in Patients Undergoing Transcatheter Aortic Valve Replacement

(2019) Hugo De Larochellière et al.   JACC-Cardiovascular Interventions

Computed tomography imaging in the context of transcatheter aortic valve implantation (TAVI) / transcatheter aortic valve replacement (TAVR): An expert consensus document of the Society of Cardiovascular Computed Tomography

(2019) Philipp Blanke et al.   Journal of Cardiovascular Computed Tomography

Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients

(2019) Jeffrey J. Popma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients

(2019) Michael J. Mack et al.   NEW ENGLAND JOURNAL OF MEDICINE

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation

(2019) Craig T. January et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Predictors, Incidence, and Outcomes of Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation Complicated by Stroke

(2019) Wieneke Vlastra et al.   Circulation-Cardiovascular Interventions

Usefulness of Clopidogrel Loading in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the BRAVO-3 Randomized Trial)

(2019) Vincent Johan Nijenhuis et al.   AMERICAN JOURNAL OF CARDIOLOGY

Defining high bleeding risk in patients undergoing percutaneous coronary intervention: a consensus document from the Academic Research Consortium for High Bleeding Risk

(2019) Philip Urban et al.   EUROPEAN HEART JOURNAL

Oral Anticoagulant Type and Outcomes After Transcatheter Aortic Valve Replacement

(2019) David Jochheim et al.   JACC-Cardiovascular Interventions

Coronary Artery Disease and Transcatheter Aortic Valve Replacement

(2019) Laurent Faroux et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

(2019) Juhani Knuuti et al.   EUROPEAN HEART JOURNAL

Safety and efficacy of a self-expanding versus a balloon-expandable bioprosthesis for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: a randomised non-inferiority trial

(2019) Jonas Lanz et al.   LANCET

Early and late risk of ischemic stroke after TAVR as compared to a nationwide background population

(2019) Ole De Backer et al.   Clinical Research in Cardiology

Reduced Leaflet Motion after Transcatheter Aortic-Valve Replacement

(2019) Ole De Backer et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement

(2019) George D. Dangas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vitamin K Antagonists versus Direct Oral Anticoagulants After Transcatheter Aortic Valve Implantation in Atrial Fibrillation

(2019) Jawad H Butt et al.   European Heart Journal-Cardiovascular Pharmacotherapy

Disappearance of Angiodysplasia Following Transcatheter Aortic Valve Implantation in a Patient with Heyde's Syndrome: A Case Report and Review of the Literature

(2019) Satoshi Tsuchiya et al.   Journal of Atherosclerosis and Thrombosis

Long-Term Safety and Efficacy in Continued Access Left Atrial Appendage Closure Registries

(2019) David R. Holmes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Variation in post-TAVR antiplatelet therapy utilization and associated outcomes: Insights from the STS/ACC TVT registry®

(2018) Matthew W. Sherwood et al.   AMERICAN HEART JOURNAL

Meta-Analysis of Studies Comparing Dual- Versus Mono-Antiplatelet Therapy Following Transcatheter Aortic Valve Implantation

(2018) Shadi Al Halabi et al.   AMERICAN JOURNAL OF CARDIOLOGY

Meta-Analysis Comparing Single Versus Dual Antiplatelet Therapy Following Transcatheter Aortic Valve Implantation

(2018) Frédéric Maes et al.   AMERICAN JOURNAL OF CARDIOLOGY

Carotid Disease and Stroke After Transcatheter Aortic Valve Replacement

(2018) Alexandra J. Lansky et al.   Circulation-Cardiovascular Interventions

NOAC monotherapy in patients with concomitant indications for oral anticoagulation undergoing transcatheter aortic valve implantation

(2018) Nicolas A. Geis et al.   Clinical Research in Cardiology

Association of aortic valve disease with intestinal angioectasia

(2018) Asad Jehangir et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Is bioprosthetic leaflet thrombosis a trigger to valve degeneration?

(2018) Mhairi Katrina Doris et al.   HEART

Debris Heterogeneity Across Different Valve Types Captured by a Cerebral Protection System During Transcatheter Aortic Valve Replacement

(2018) Tobias Schmidt et al.   JACC-Cardiovascular Interventions

1-Year Clinical Outcomes in Women After Transcatheter Aortic Valve Replacement

(2018) Alaide Chieffo et al.   JACC-Cardiovascular Interventions

Effect of Mechanically Expanded vs Self-Expanding Transcatheter Aortic Valve Replacement on Mortality and Major Adverse Clinical Events in High-Risk Patients With Aortic Stenosis

(2018) Ted E. Feldman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aortic stenosis and anemia with an update on approaches to managing angiodysplasia in 2018

(2018) Kevin Mohee et al.   Cardiology Journal

Incidence, Management, and Associated Clinical Outcomes of New-Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement

(2018) Amit N. Vora et al.   JACC-Cardiovascular Interventions

Long-Term Mortality and Early Valve Dysfunction According to Anticoagulation Use: The FRANCE-TAVI registry

(2018) Pavel Overtchouk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

(2018) John J. McNeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Patients at low surgical risk as defined by the Society of Thoracic Surgeons Score undergoing isolated interventional or surgical aortic valve implantation: in-hospital data and 1-year results from the German Aortic Valve Registry (GARY)

(2018) Raffi Bekeredjian et al.   EUROPEAN HEART JOURNAL

1-Year Outcomes With the Evolut R Self-Expanding Transcatheter Aortic Valve

(2018) Ganesh Manoharan et al.   JACC-Cardiovascular Interventions

Transcatheter Aortic Heart Valves

(2018) Stephanie L. Sellers et al.   JACC-Cardiovascular Imaging

2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

(2017) Marco Valgimigli et al.   EUROPEAN HEART JOURNAL

Natural history of subclinical leaflet thrombosis affecting motion in bioprosthetic aortic valves

(2017) Lars Sondergaard et al.   EUROPEAN HEART JOURNAL

2017 ESC/EACTS Guidelines for the management of valvular heart disease

(2017) Helmut Baumgartner et al.   EUROPEAN HEART JOURNAL

Can TAVI patients receive aspirin monotherapy as patients after surgical aortic bioprosthesis implantation? Data from the Polish Registry — POL-TAVI

(2017) Katarzyna Czerwińska-Jelonkiewicz et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Predictors of cerebrovascular events at mid-term after transcatheter aortic valve implantation – Results from EVERY-TAVI registry

(2017) David Jochheim et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Apixaban in Patients With Atrial Fibrillation After Transfemoral Aortic Valve Replacement

(2017) Julia Seeger et al.   JACC-Cardiovascular Interventions

Clinical Bioprosthetic Heart Valve Thrombosis After Transcatheter Aortic Valve Replacement

(2017) John Jose et al.   JACC-Cardiovascular Interventions

Frequency, Timing, and Impact of Access-Site and Non–Access-Site Bleeding on Mortality Among Patients Undergoing Transcatheter Aortic Valve Replacement

(2017) Raffaele Piccolo et al.   JACC-Cardiovascular Interventions

Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement Significantly Reduces Death and Stroke Compared With Unprotected Procedures

(2017) Julia Seeger et al.   JACC-Cardiovascular Interventions

Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve

(2017) Josep Rodés-Cabau et al.   JACC-Cardiovascular Interventions

Protection Against Cerebral Embolism During Transcatheter Aortic Valve Replacement

(2017) Samir R. Kapadia et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aortic Bioprosthetic Valve Durability

(2017) Tania Rodriguez-Gabella et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study

(2017) Tarun Chakravarty et al.   LANCET

Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients

(2017) Michael J. Reardon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcatheter aortic valve implantation leads to a restoration of von Willebrand factor (VWF) abnormalities in patients with severe aortic stenosis – Incidence and relevance of clinical and subclinical VWF dysfunction in patients undergoing transfemoral TAVI

(2017) Alexander Sedaghat et al.   THROMBOSIS RESEARCH

Incidence, Predictors, and Mid-Term Outcomes of Possible Leaflet Thrombosis After TAVR

(2017) Ryo Yanagisawa et al.   JACC-Cardiovascular Imaging

Feasibility and safety of vitamin K antagonist monotherapy in atrial fibrillation patients undergoing transcatheter aortic valve implantation

(2017) Nicolas Geis et al.   EuroIntervention

Risk of bleeding after hospitalization for a serious coronary event: a retrospective cohort study with nested case-control analyses

(2016) Antonio González-Pérez et al.   BMC Cardiovascular Disorders

Temporal Trends in the Risk Profile of Patients Undergoing Outpatient Percutaneous Coronary Intervention

(2016) Amit N. Vora et al.   Circulation-Cardiovascular Interventions

The toxicology of heparin reversal with protamine: past, present and future

(2016) Emilia Sokolowska et al.   Expert Opinion on Drug Metabolism & Toxicology

Pre-procedural dual antiplatelet therapy in patients undergoing transcatheter aortic valve implantation increases risk of bleeding

(2016) Hirofumi Hioki et al.   HEART

Warfarin and Antiplatelet Therapy Versus Warfarin Alone for Treating Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement

(2016) Omar Abdul-Jawad Altisent et al.   JACC-Cardiovascular Interventions

Effect of a Cerebral Protection Device on Brain Lesions Following Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis

(2016) Stephan Haussig et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prosthetic Heart Valve Thrombosis

(2016) George D. Dangas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Late Outcomes of Transcatheter Aortic Valve Replacement in High-Risk Patients

(2016) Martine Gilard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Von Willebrand Factor Multimers during Transcatheter Aortic-Valve Replacement

(2016) Eric Van Belle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients

(2016) Martin B. Leon et al.   NEW ENGLAND JOURNAL OF MEDICINE

One-year outcomes with two suture-mediated closure devices to achieve access-site haemostasis following transfemoral transcatheter aortic valve implantation

(2016) Julinda Mehilli et al.   EuroIntervention

Filter-based cerebral embolic protection with transcatheter aortic valve implantation: the randomised MISTRAL-C trial

(2016) Nicolas M. Van Mieghem et al.   EuroIntervention

Treatment and Clinical Outcomes of Transcatheter Heart Valve Thrombosis

(2015) A. Latib et al.   Circulation-Cardiovascular Interventions

Antithrombotic therapy in the elderly: expert position paper of the European Society of Cardiology Working Group on Thrombosis

(2015) Felicita Andreotti et al.   EUROPEAN HEART JOURNAL

Early hypo-attenuated leaflet thickening in balloon-expandable transcatheter aortic heart valves

(2015) Gregor Pache et al.   EUROPEAN HEART JOURNAL

Comparison of vascular closure devices for access site closure after transfemoral aortic valve implantation

(2015) Israel M. Barbash et al.   EUROPEAN HEART JOURNAL

1-Year Outcomes After Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expandable Valves

(2015) Mohamed Abdel-Wahab et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Bivalirudin Versus Heparin Anticoagulation in Transcatheter Aortic Valve Replacement

(2015) George D. Dangas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves

(2015) Raj R. Makkar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antithrombotic treatment in patients undergoing transcatheter aortic valve implantation (TAVI)

(2015) Vincent J. Nijenhuis et al.   THROMBOSIS AND HAEMOSTASIS

SAT-TAVI (single antiplatelet therapy for TAVI) study: A pilot randomized study comparing double to single antiplatelet therapy for transcatheter aortic valve implantation

(2014) Eugenio Stabile et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Incidence, Predictors, and Prognostic Impact of Late Bleeding Complications After Transcatheter Aortic Valve Replacement

(2014) Philippe Généreux et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of Two Antiplatelet Therapy Strategies in Patients Undergoing Transcatheter Aortic Valve Implantation

(2013) Eric Durand et al.   AMERICAN JOURNAL OF CARDIOLOGY

Histopathology of Embolic Debris Captured During Transcatheter Aortic Valve Replacement

(2013) Nicolas M. Van Mieghem et al.   CIRCULATION

Timing, Predictive Factors, and Prognostic Value of Cerebrovascular Events in a Large Cohort of Patients Undergoing Transcatheter Aortic Valve Implantation

(2012) Luis Nombela-Franco et al.   CIRCULATION

2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aortic valve replacement

(2012) David R. Holmes et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Percutaneous closure of left atrial appendage after transcatheter aortic valve implantation - an interventional approach to avoid anticoagulation therapy in elderly patients: TAVI and closure of LAA to avoid warfarin therapy

(2012) Nikola Bogunovic et al.   EuroIntervention

Dual Antiplatelet Therapy Versus Aspirin Alone in Patients Undergoing Transcatheter Aortic Valve Implantation

(2011) Gian Paolo Ussia et al.   AMERICAN JOURNAL OF CARDIOLOGY

A High-Risk Period for Cerebrovascular Events Exists After Transcatheter Aortic Valve Implantation

(2011) Edgar L.W. Tay et al.   JACC-Cardiovascular Interventions

Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

(2011) Craig R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE