Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis

(2020) Hui Chen et al.   CELL DEATH AND DIFFERENTIATION

Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS

(2020) Hui Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

18F-FDG PET imaging of myocardial inflammation and viability following experimental infarction and anti-inflammatory treatment with compound MCC950

(2020) Jeremy Jong et al.   JOURNAL OF NUCLEAR CARDIOLOGY

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

The role of microglia mediated pyroptosis in neonatal hypoxic-ischemic brain damage

(2019) Yuan Lv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

(2018) Apurva Kanneganti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

(2018) SangJoon Lee et al.   JOURNAL OF VIROLOGY

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

(2018) Agampodi Promoda Perera et al.   Scientific Reports

Berberine-piperazine conjugates as potent influenza neuraminidase blocker

(2018) Ganuskh Enkhtaivan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Influenza and Viral Pneumonia

(2018) Rodrigo Cavallazzi et al.   CLINICS IN CHEST MEDICINE

Structural Insight into a Human Neutralizing Antibody against Influenza Virus H7N9

(2017) Cong Chen et al.   JOURNAL OF VIROLOGY

New fronts emerge in the influenza cytokine storm

(2017) Xi-zhi J. Guo et al.   Seminars in Immunopathology

Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection

(2017) Bria M. Coates et al.   Frontiers in Immunology

14-Deoxy-11,12-didehydroandrographolide attenuates excessive inflammatory responses and protects mice lethally challenged with highly pathogenic A(H5N1) influenza viruses

(2016) Wentao Cai et al.   ANTIVIRAL RESEARCH

1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

(2016) Yun Li et al.   INFLAMMATION

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Pistacia integerrima ameliorates airway inflammation by attenuation of TNF-α, IL-4, and IL-5 expression levels, and pulmonary edema by elevation of AQP1 and AQP5 expression levels in mouse model of ovalbumin-induced allergic asthma

(2016) Shazana Rana et al.   PHYTOMEDICINE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

(2016) Jeroen Slaats et al.   PLoS Pathogens

The Role of Viral, Host, and Secondary Bacterial Factors in Influenza Pathogenesis

(2015) John C. Kash et al.   AMERICAN JOURNAL OF PATHOLOGY

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Current knowledge and pharmacological profile of berberine: An update

(2015) Anil Kumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells

(2015) Melissa Victoria Fernandez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1

(2014) Peter A. Keyel   CYTOKINE

Ability of Recombinant Human Catalase to Suppress Inflammation of the Murine Lung Induced by Influenza A

(2014) Xunlong Shi et al.   INFLAMMATION

Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice

(2014) Haiyan Zhu et al.   INFLAMMATION

Antiviral combinations for severe influenza

(2014) Jake Dunning et al.   LANCET INFECTIOUS DISEASES

Influenza virus resistance to neuraminidase inhibitors

(2013) Mélanie Samson et al.   ANTIVIRAL RESEARCH

Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts

(2013) Chi Man Tsang et al.   BMC CANCER

Influenza and Endemic Viral Pneumonia

(2013) Clare D. Ramsey et al.   CRITICAL CARE CLINICS

Intracellular trafficking and secretion of inflammatory cytokines

(2013) Jennifer L. Stow et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways

(2012) Liyun Jia et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Molecular basis of the structure and function of H1 hemagglutinin of influenza virus

(2012) Nongluk SRIWILAIJAROEN et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Interleukin-6: from an inflammatory marker to a target for inflammatory diseases

(2012) Mercedes Rincon   TRENDS IN IMMUNOLOGY

Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)

(2011) Chad E. Cecil et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability

(2011) Narasaiah Kolliputi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Risk factors of A/H1N1 etiology in pneumonia and its impact on mortality

(2011) S. Reyes et al.   RESPIRATORY MEDICINE

Complications of seasonal and pandemic influenza

(2010) Michael B. Rothberg et al.   CRITICAL CARE MEDICINE

The Inflammasome Mediates Hyperoxia-Induced Alveolar Cell Permeability

(2010) N. Kolliputi et al.   JOURNAL OF IMMUNOLOGY

Amantadine-resistant influenza A viruses isolated in South Korea from 2003 to 2009

(2009) Woo-Young Choi et al.   ANTIVIRAL RESEARCH

Evaluation by survival analysis on effect of traditional Chinese medicine in treating children with respiratory syncytial viral pneumonia of phlegm-heat blocking Fei syndrome

(2009) Yan Yang et al.   Chinese Journal of Integrative Medicine

Mutational Analysis of Conserved Amino Acids in the Influenza A Virus Nucleoprotein

(2009) Z. Li et al.   JOURNAL OF VIROLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Original Research: Intravenous Ribavirin—Review of the FDA's Emergency Investigational New Drug Database (1997–2008) and Literature Review

(2009) Andrea Riner et al.   POSTGRADUATE MEDICINE

Innate immune responses to influenza A H5N1: friend or foe?

(2009) Joseph Sriyal Malik Peiris et al.   TRENDS IN IMMUNOLOGY

Structure and sequence analysis of influenza A virus nucleoprotein

(2009) Andy Ka-Leung Ng et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

An improved embryonated chicken egg model for the evaluation of antiviral drugs against influenza A virus

(2008) Ji-Xi Wang et al.   JOURNAL OF VIROLOGICAL METHODS

Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus

(2008) Mayo Ueda et al.   VIRUS RESEARCH

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL