A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm

(2014) Pawan Gulati et al.   BIOSCIENCE REPORTS

Obesity and FTO: Changing Focus at a Complex Locus

(2014) Y.C. Loraine Tung et al.   Cell Metabolism

FTO Genotype, Physical Activity, and Coronary Heart Disease Risk in Swedish Men and Women

(2014) J. Gustavsson et al.   Circulation-Cardiovascular Genetics

Association of the FTO gene SNP rs17817449 with body fat distribution in Mexican women

(2014) J.J. Zermeño-Rivera et al.   GENETICS AND MOLECULAR RESEARCH

FTO gene variant and risk of hypertension: A meta-analysis of 57,464 hypertensive cases and 41,256 controls

(2014) Dan He et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy

(2014) Rosario Liguori et al.   MOLECULAR AND CELLULAR PROBES

Association between Fat Mass- and Obesity- Associated (FTO) Gene Polymorphism and Polycystic Ovary Syndrome: A Meta-Analysis

(2014) Xianli Cai et al.   PLoS One

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

(2013) Toshiko Tanaka et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Association of the FTO Obesity Risk Variant rs8050136 With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations

(2013) Sungshim Lani Park et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course

(2013) Mariaelisa Graff et al.   HUMAN MOLECULAR GENETICS

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

(2013) Eleanor Wheeler et al.   NATURE GENETICS

The bigger picture of FTO—the first GWAS-identified obesity gene

(2013) Ruth J. F. Loos et al.   Nature Reviews Endocrinology

How to Perform a Punch Biopsy of the Skin

(2013) Jacob Levitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The missense variation landscape ofFTO,MC4R,andTMEM18in obese children of African Ancestry

(2013) Sandra Deliard et al.   Obesity

Screening for Coding Variants in FTO and SH2B1 Genes in Chinese Patients with Obesity

(2013) Zhaojing Zheng et al.   PLoS One

Role for the obesity-related FTO gene in the cellular sensing of amino acids

(2013) P. Gulati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced memory in fat mass and obesity-associated allele carriers among older adults with cardiovascular disease

(2013) Michael L. ALOSCO et al.   Psychogeriatrics

Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO

(2013) V. E. Clark et al.   SCIENCE

FTO levels affect RNA modification and the transcriptome

(2012) Tea Berulava et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

FTO, obesity and the adolescent brain

(2012) Melkaye G. Melka et al.   HUMAN MOLECULAR GENETICS

FTO genotype is associated with phenotypic variability of body mass index

(2012) Jian Yang et al.   NATURE

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

(2012) Momoko Horikoshi et al.   NATURE GENETICS

A genome-wide association meta-analysis identifies new childhood obesity loci

(2012)   NATURE GENETICS

Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals

(2011) Tuomas O Kilpeläinen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV

(2011) Jarupon Fah Sathirapongsasuti et al.   BIOINFORMATICS

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men

(2011) Christian Benedict et al.   NEUROBIOLOGY OF AGING

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

(2011) Ulla Sovio et al.   PLoS Genetics

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

Investigation of a patient with a partial trisomy 16q including the fat mass and obesity associated gene (FTO): Fine mapping andFTOgene expression study

(2010) Linda van den Berg et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The obesity-associated Fto gene is a transcriptional coactivator

(2010) Qiong Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A FTO variant and risk of acute coronary syndrome

(2010) Jaroslav A. Hubacek et al.   CLINICA CHIMICA ACTA

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

(2010) Cathy E Elks et al.   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Where to go with FTO?

(2010) Rachel Larder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The genetics of obesity: FTO leads the way

(2010) Katherine A. Fawcett et al.   TRENDS IN GENETICS

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

The FTO gene rs9939609 obesity-risk allele and loss of control over eating

(2009) Marian Tanofsky-Kraff et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity

(2009) Emily Sonestedt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

(2009) Sarah Boissel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a caucasian kindred

(2009) Laura Calabresi et al.   ATHEROSCLEROSIS

Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals

(2009) D. Meyre et al.   DIABETES

Life course variations in the associations between FTO and MC4R gene variants and body size

(2009) R. Hardy et al.   HUMAN MOLECULAR GENETICS

Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome

(2009) Elisabeth Wehr et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Genetic diagnosis by whole exome capture and massively parallel DNA sequencing

(2009) Murim Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

(2009) Cecilia M. Lindgren et al.   PLoS Genetics

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Regulation of Fto/Ftm gene expression in mice and humans

(2008) George Stratigopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

(2008) Guifang Jia et al.   FEBS LETTERS

Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study

(2008) T Jess et al.   INTERNATIONAL JOURNAL OF OBESITY

The FTO gene and measured food intake in children

(2008) J Wardle et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity Associated Genetic Variation inFTOIs Associated with Diminished Satiety

(2008) Jane Wardle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

An Obesity-AssociatedFTOGene Variant and Increased Energy Intake in Children

(2008) Joanne E. Cecil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymorphisms of theFTOGene Are Associated With Variation in Energy Intake, but not Energy Expenditure

(2008) John R. Speakman et al.   Obesity