Discovery of Benzo[ d ]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Discovery of Benzo[
d
]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain
Authors
Keywords
-
Journal
ChemMedChem
Volume 17, Issue 20, Pages -
Publisher
Wiley
Online
2022-08-30
DOI
10.1002/cmdc.202200343
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development
- (2022) Juncheng Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development
- (2021) Pan Tang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Achieving clinical success with BET inhibitors as anti-cancer agents
- (2021) Tatiana Shorstova et al. BRITISH JOURNAL OF CANCER
- Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit
- (2021) Francesco Rianjongdee et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy
- (2021) Bo Kong et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening
- (2020) Christopher R. Wellaway et al. JOURNAL OF MEDICINAL CHEMISTRY
- Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal
- (2020) Qiang Zhao et al. Frontiers in Pharmacology
- Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation
- (2020) Omer Gilan et al. SCIENCE
- Targeting epigenetic reader domains by chemical biology
- (2020) Alessandra Cipriano et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins
- (2020) Robert J. Watson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure
- (2019) Ciro Milite et al. JOURNAL OF MEDICINAL CHEMISTRY
- Bromodomains: a new target class for drug development
- (2019) Andrea G. Cochran et al. NATURE REVIEWS DRUG DISCOVERY
- Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis
- (2019) Fei Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain
- (2018) Robert P. Law et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
- (2018) David Sperandio et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Drug Discovery Targeting Bromodomain-Containing Protein 4
- (2017) Zhiqing Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor
- (2017) Keith F. McDaniel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
- (2017) Takao Fujisawa et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Azoreductases in drug metabolism
- (2016) Ali Ryan BRITISH JOURNAL OF PHARMACOLOGY
- A Novel Cell-Permeable, Selective, and Noncompetitive Inhibitor of KAT3 Histone Acetyltransferases from a Combined Molecular Pruning/Classical Isosterism Approach
- (2015) Ciro Milite et al. JOURNAL OF MEDICINAL CHEMISTRY
- Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry
- (2014) Rangappa S. Keri et al. Chemical Biology & Drug Design
- Selective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage Progression
- (2014) Mar Gacias et al. CHEMISTRY & BIOLOGY
- Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
- (2014) Duncan A. Hay et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
- (2013) Guangtao Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
- (2011) Panagis Filippakopoulos et al. BIOORGANIC & MEDICINAL CHEMISTRY
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- Targeting MYC dependence in cancer by inhibiting BET bromodomains
- (2011) J. A. Mertz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
- (2010) Fraser F. Fleming et al. JOURNAL OF MEDICINAL CHEMISTRY
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data
- (2009) Elena Dreassi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Physicochemical drug properties associated within vivotoxicological outcomes: a review
- (2009) David A Price et al. Expert Opinion on Drug Metabolism & Toxicology
- Optical Switches for Remote and Noninvasive Control of Cell Signaling
- (2008) P. Gorostiza et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started