The evolutionary potential of influenza A virus hemagglutinin is highly constrained by epistatic interactions with neuraminidase

Viral protein instability enhances host-range evolvability

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Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing

(2021) Yiquan Wang et al.   eLife

Neuraminidase antigenic drift of H3N2 clade 3c.2a viruses alters virus replication, enzymatic activity and inhibitory antibody binding

(2020) Harrison Powell et al.   PLoS Pathogens

Influenza Hemagglutinin and Neuraminidase: Yin–Yang Proteins Coevolving to Thwart Immunity

(2019) Ivan Kosik et al.   Viruses-Basel

Influenza A virus surface proteins are organized to help penetrate host mucus

(2019) Michael D Vahey et al.   eLife

Global mortality associated with seasonal influenza epidemics: New burden estimates and predictors from the GLaMOR Project

(2019) John Paget et al.   Journal of Global Health

Influenza A Virus Hemagglutinin–Neuraminidase–Receptor Balance: Preserving Virus Motility

(2019) Erik de Vries et al.   TRENDS IN MICROBIOLOGY

A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

(2018) Nicholas C. Wu et al.   Nature Communications

Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs

(2018) Ivan Kosik et al.   PLoS Pathogens

Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

(2018) Juhye M. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-Fidelity Assembly of Influenza A Virus Promotes Escape from Host Cells

(2018) Michael D. Vahey et al.   CELL

Population Diversity and Collective Interactions during Influenza Virus Infection

(2017) Christopher B. Brooke   JOURNAL OF VIROLOGY

The evolution of seasonal influenza viruses

(2017) Velislava N. Petrova et al.   NATURE REVIEWS MICROBIOLOGY

The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus

(2017) Netanel Tzarum et al.   Cell Reports

Complete mapping of viral escape from neutralizing antibodies

(2017) Michael B. Doud et al.   PLoS Pathogens

A novel twelve class fluctuation test reveals higher than expected mutation rates for influenza A viruses

(2017) Matthew D Pauly et al.   eLife

Functional balance between neuraminidase and haemagglutinin in influenza viruses

(2016) A. Gaymard et al.   CLINICAL MICROBIOLOGY AND INFECTION

Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin

(2016) Michael Doud et al.   Viruses-Basel

The Mutational Robustness of Influenza A Virus

(2016) Elisa Visher et al.   PLoS Pathogens

The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans

(2015) Katia Koelle et al.   eLife

Subclonal variant calling with multiple samples and prior knowledge

(2014) M. Gerstung et al.   BIOINFORMATICS

Deep mutational scanning: a new style of protein science

(2014) Douglas M Fowler et al.   NATURE METHODS

Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility

(2014) Christopher B. Brooke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution

(2014) Nicholas C. Wu et al.   Scientific Reports

Defining Influenza A Virus Hemagglutinin Antigenic Drift by Sequential Monoclonal Antibody Selection

(2013) Suman R. Das et al.   Cell Host & Microbe

The role of mutational robustness in RNA virus evolution

(2013) Adam S. Lauring et al.   NATURE REVIEWS MICROBIOLOGY

Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus

(2013) C. M. H. Randall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

(2013) B. F. Koel et al.   SCIENCE

Clinical and molecular characteristics of the 2009 pandemic influenza H1N1 infection with severe or fatal disease from 2009 to 2011 in Shenzhen, China

(2012) Chunli Wu et al.   JOURNAL OF MEDICAL VIROLOGY

Functional Balance of the Hemagglutinin and Neuraminidase Activities Accompanies the Emergence of the 2009 H1N1 Influenza Pandemic

(2012) R. Xu et al.   JOURNAL OF VIROLOGY

Distribution of surface glycoproteins on influenza A virus determined by electron cryotomography

(2012) Sebastian Wasilewski et al.   VACCINE

Reliable detection of subclonal single-nucleotide variants in tumour cell populations

(2012) Moritz Gerstung et al.   Nature Communications

RNA virus genetic robustness: possible causes and some consequences

(2012) Santiago F Elena   Current Opinion in Virology

FLASH: fast length adjustment of short reads to improve genome assemblies

(2011) T. Magoc et al.   BIOINFORMATICS

Structural Characterization of the Hemagglutinin Receptor Specificity from the 2009 H1N1 Influenza Pandemic

(2011) R. Xu et al.   JOURNAL OF VIROLOGY

Influenza A Virus Hemagglutinin Antibody Escape Promotes Neuraminidase Antigenic Variation and Drug Resistance

(2011) Scott E. Hensley et al.   PLoS One

Viva la revolución: rethinking influenza A virus antigenic drift

(2011) Jonathan W Yewdell   Current Opinion in Virology

Prevalence of Epistasis in the Evolution of Influenza A Surface Proteins

(2011) Sergey Kryazhimskiy et al.   PLoS Genetics

Monoclonal antibodies specific for discontinuous epitopes direct refolding of influenza A virus hemagglutinin

(2010) Jonathan W. Yewdell   MOLECULAR IMMUNOLOGY

Mutational robustness can facilitate adaptation

(2010) Jeremy A. Draghi et al.   NATURE

Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies

(2010) R. Sanjuan   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

Biopython: freely available Python tools for computational molecular biology and bioinformatics

(2009) P. J. A. Cock et al.   BIOINFORMATICS

Robustness promotes evolvability of thermotolerance in an RNA virus

(2008) Robert C McBride et al.   BMC EVOLUTIONARY BIOLOGY