Intrinsic Antibacterial Activity of Xeruborbactam In Vitro : Assessing Spectrum and Mode of Action

In Vitro Activity of the Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa

(2021) Olga Lomovskaya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics

(2021) Olga Lomovskaya et al.   Frontiers in Microbiology

The Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 Restores the Potency of Multiple Oral Beta-Lactam Antibiotics against Beta-Lactamase-Producing Strains of Resistant Enterobacterales

(2021) Olga Lomovskaya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases

(2020) Ruslan Tsivkovski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

(2020) Olga Lomovskaya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

(2020) Olga Lomovskaya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activity of the Ultra-Broad-Spectrum Beta-lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales (CRE) With Varying Intrinsic and Acquired Resistance Mechanisms

(2020) Kirk Nelson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The multifarious roles of Tol-Pal in Gram-negative bacteria

(2020) Joanna Szczepaniak et al.   FEMS MICROBIOLOGY REVIEWS

Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

(2020) Scott J. Hecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of peptidoglycan synthesis and remodelling

(2020) Alexander J. F. Egan et al.   NATURE REVIEWS MICROBIOLOGY

In Vitro Characterization of ETX1317, a Broad-Spectrum β-Lactamase Inhibitor That Restores and Enhances β-Lactam Activity against Multi-Drug-Resistant Enterobacteriales, Including Carbapenem-Resistant Strains

(2020) Alita A. Miller et al.   ACS Infectious Diseases

In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii

(2020) Kirk Nelson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Morphological Deconvolution of Beta-Lactam Polyspecificity in E. coli

(2019) William J. Godinez et al.   ACS Chemical Biology

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

(2019) Bin Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae

(2018) Dhruvitkumar S. Sutaria et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distinct role of outer membrane protein A in the intrinsic resistance of Acinetobacter baumannii and Acinetobacter nosocomialis

(2018) Hyo Il Kwon et al.   INFECTION GENETICS AND EVOLUTION

In vitro activity of cefepime/zidebactam (WCK 5222) against Gram-negative bacteria

(2017) David M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Don’t let sleeping dogmas lie: new views of peptidoglycan synthesis and its regulation

(2017) Heng Zhao et al.   MOLECULAR MICROBIOLOGY

The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli

(2017) Ghee Chuan Lai et al.   PLoS Genetics

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii

(2017) Thomas F. Durand-Réville et al.   Nature Microbiology

New insights into the regulatory pathways associated with the activation of the stringent response in bacterial resistance to the PBP2-targeted antibiotics, mecillinam and OP0595/RG6080

(2016) M. Doumith et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

(2015) William F. Penwell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Profiling of β-Lactam Selectivity for Penicillin-Binding Proteins in Escherichia coli Strain DC2

(2015) Ozden Kocaoglu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria

(2015) Abdelhamid Asli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interactions of OP0595, a Novel Triple-Action Diazabicyclooctane, with β-Lactams against OP0595-Resistant Enterobacteriaceae Mutants

(2015) David M. Livermore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization ofEscherichia coliNDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3

(2015) Richard A. Alm et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’

(2015) Akihiro Morinaka et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

(2015) Andrew N Gray et al.   eLife

In VitroActivity of Ceftazidime-Avibactam Combination inIn VitroCheckerboard Assays

(2014) Johanna Berkhout et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

(2013) P. Nonejuie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae

(2011) R. Rosenblum et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

ramR Mutations in Clinical Isolates of Klebsiella pneumoniae with Reduced Susceptibility to Tigecycline

(2010) M. Hentschke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa

(2008) T. A. Davies et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY