An ROS-responsive artesunate prodrug nanosystem co-delivers dexamethasone for rheumatoid arthritis treatment through the HIF-1α/NF-κB cascade regulation of ROS scavenging and macrophage repolarization

Emerging small molecule-engineered hybrid nanomedicines for cancer therapy

(2022) Yao Chen et al.   CHEMICAL ENGINEERING JOURNAL

Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62/Nrf2 signaling

(2021) Xiaohui Su et al.   BIOMEDICINE & PHARMACOTHERAPY

Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats

(2020) Yiping Hu et al.   Molecular Therapy-Nucleic Acids

A pH/ROS-responsive, tumor-targeted drug delivery system based on carboxymethyl chitin gated hollow mesoporous silica nanoparticles for anti-tumor chemotherapy

(2020) Xiao Ding et al.   CARBOHYDRATE POLYMERS

Codelivered Chemotherapeutic Doxorubicin via a Dual-Functional Immunostimulatory Polymeric Prodrug for Breast Cancer Immunochemotherapy

(2020) Yang Lan et al.   ACS Applied Materials & Interfaces

Inflammation-Targeted Celastrol Nanodrug Attenuates Collagen-Induced Arthritis through NF-κB and Notch1 Pathways

(2020) Lemei An et al.   NANO LETTERS

The immunology of rheumatoid arthritis

(2020) Cornelia M. Weyand et al.   NATURE IMMUNOLOGY

pH-responsive hyaluronic acid-based nanoparticles for targeted curcumin delivery and enhanced cancer therapy

(2020) Hualu Lai et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment

(2019) Jonghoon Kim et al.   ACS Nano

Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway

(2019) Rongrong Ni et al.   BIOMATERIALS

Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis

(2018) Abdul-Rehman Phull et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A novel dexamethasone-loaded liposome alleviates rheumatoid arthritis in rats

(2018) Mengdi Jia et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dexamethasone counteracts hepatic inflammation and oxidative stress in cholestatic rats via CAR activation

(2018) Daniela Gabbia et al.   PLoS One

M2 macrophages and their role in rheumatic diseases

(2018) Shruti Bhattacharya et al.   RHEUMATOLOGY INTERNATIONAL

Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles

(2018) Ruixiang Li et al.   NANO LETTERS

Curcumin inhibits lipopolysaccharide (LPS)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (TNF-α and TGF-β1) in murine model

(2017) Asha Kumari et al.   INFLAMMOPHARMACOLOGY

Reactive oxygen and nitrogen species in patients with rheumatoid arthritis as potential biomarkers for disease activity and the role of antioxidants

(2016) Hani M. Khojah et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeted delivery of low-dose dexamethasone using PCL–PEG micelles for effective treatment of rheumatoid arthritis

(2016) Qin Wang et al.   JOURNAL OF CONTROLLED RELEASE

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

Bactericidal Effect of Lauric Acid-Loaded PCL-PEG-PCL Nano-Sized Micelles on Skin Commensal Propionibacterium acnes

(2016) Thi-Quynh-Mai Tran et al.   Polymers

Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships

(2015) Abigail Hielscher et al.   FREE RADICAL BIOLOGY AND MEDICINE

A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

(2014) Jung Min Shin et al.   CHEMICAL COMMUNICATIONS

The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis

(2012) Ji Sun Park et al.   BIOMATERIALS

Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia

(2011) Yingqian Huo et al.   BMC NEUROSCIENCE

The Bone, the Joints and the Balm of Gilead

(2011) Dong Wang et al.   MOLECULAR PHARMACEUTICS

Liposomal dexamethasone–diclofenac combinations for local osteoarthritis treatment

(2009) Inbar Elron-Gross et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The anti-malaria agent artesunate inhibits expression of vascular endothelial growth factor and hypoxia-inducible factor-1α in human rheumatoid arthritis fibroblast-like synoviocyte

(2009) Ya He et al.   RHEUMATOLOGY INTERNATIONAL

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL