Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62/Nrf2 signaling

Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response

(2019) Yi Yang et al.   Nature Communications

Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis

(2018) Fa-Bo Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

Glycyrrhizin Suppresses RANKL-Induced Osteoclastogenesis and Oxidative Stress Through Inhibiting NF-κB and MAPK and Activating AMPK/Nrf2

(2018) Zhikun Li et al.   CALCIFIED TISSUE INTERNATIONAL

Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis

(2018) Abdul-Rehman Phull et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Artesunate Inhibits Renal Ischemia-Reperfusion-Mediated Remote Lung Inflammation Through Attenuating ROS-Induced Activation of NLRP3 Inflammasome

(2018) Zhaohui Liu et al.   INFLAMMATION

TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy

(2018) Kautilya Kumar Jena et al.   EMBO JOURNAL

Artesunate inhibits fibroblasts proliferation and reduces surgery-induced epidural fibrosis via the autophagy-mediated p53/p21waf1/cip1 pathway

(2018) Qi Wan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Artesunate Protects LPS-Induced Acute Lung Injury by Inhibiting TLR4 Expression and Inducing Nrf2 Activation

(2017) Deli Zhao et al.   INFLAMMATION

DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation

(2017) Hyuk Soon Kim et al.   Nature Communications

The Suppressive Effects of the Petroleum Ether Fraction fromAtractylodes lancea(Thunb.) DC. On a Collagen-Induced Arthritis Model

(2016) Renping Liu et al.   PHYTOTHERAPY RESEARCH

Dihydromyricetin suppresses inflammatory responsesin vitroandin vivothrough inhibition of IKKβ activity in macrophages

(2016) Rui Wang et al.   SCANNING

Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis

(2016) Somaiya Mateen et al.   PLoS One

NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1

(2016) In Soon Kang et al.   Scientific Reports

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

(2015) Justyna Rzepecka et al.   JOURNAL OF AUTOIMMUNITY

New Insights Into the Role of Sequestosome 1/p62 Mutant Proteins in the Pathogenesis of Paget's Disease of Bone

(2013) Sarah L. Rea et al.   ENDOCRINE REVIEWS

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL

(2012) Tapasi Rana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress as a potential biomarker for determining disease activity in patients with Rheumatoid Arthritis

(2012) Sunanda Kundu et al.   FREE RADICAL RESEARCH

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor kappa B and mitogen-activated protein kinase signaling pathway

(2012) Yanmei Li et al.   Translational Research

Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease

(2011) Nuria Maicas et al.   ANTIOXIDANTS & REDOX SIGNALING

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction

(2010) So Youn Park et al.   ARTHRITIS AND RHEUMATISM

Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production

(2010) Xu He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RANKL-mediated Reactive Oxygen Species Pathway That Induces Long Lasting Ca2+Oscillations Essential for Osteoclastogenesis

(2010) Min Seuk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells

(2010) Ik-Soo Lee et al.   NEUROCHEMISTRY INTERNATIONAL

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY