Dendrimer–siRNA Conjugates for Targeted Intracellular Delivery in Glioblastoma Animal Models

Dendrimer nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial

(2022) Aaron M. Gusdon et al.   Science Translational Medicine

BBB pathophysiology–independent delivery of siRNA in traumatic brain injury

(2021) Wen Li et al.   Science Advances

Progress on siRNA-based gene therapy targeting secondary injury after intracerebral hemorrhage

(2021) Daniyah A. Almarghalani et al.   GENE THERAPY

Dense hydroxyl polyethylene glycol dendrimer targets activated glia in multiple CNS disorders

(2020) Anjali Sharma et al.   Science Advances

Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury

(2020) Rishi Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC

(2020) Babak Basiri et al.   Molecular Therapy-Nucleic Acids

An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

(2020) Dinesh Dhumal et al.   Nano Research

Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing

(2019) Yuan Rui et al.   ACS Applied Materials & Interfaces

Strategies, design, and chemistry in siRNA delivery systems

(2019) Yizhou Dong et al.   ADVANCED DRUG DELIVERY REVIEWS

Clinical advances of siRNA therapeutics

(2019) Bo Hu et al.   JOURNAL OF GENE MEDICINE

Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery

(2019) Byungji Kim et al.   ADVANCED MATERIALS

Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector

(2019) Aleksandra Ellert-Miklaszewska et al.   Nanomedicine

Disulfide‐Based Self‐Immolative Linkers and Functional Bioconjugates for Biological Applications

(2019) Zhengyu Deng et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

(2018) Maja M. Janas et al.   Nature Communications

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

A user's guide to the thiol-thioester exchange in organic media: scope, limitations, and applications in material science

(2018) Brady T. Worrell et al.   Polymer Chemistry

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

(2018) Yiwen Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic–ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia

(2017) Christina L. Nemeth et al.   Nanomedicine-Nanotechnology Biology and Medicine

Advances in siRNA delivery in cancer therapy

(2017) Aishwarya Singh et al.   Artificial Cells Nanomedicine and Biotechnology

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

(2017) Katyayani Tatiparti et al.   Nanomaterials

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

(2017) Yu Cao et al.   Frontiers of Chemical Science and Engineering

Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury

(2017) Jun Lei et al.   Scientific Reports

Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides

(2016) Jade J. Welch et al.   ACS Medicinal Chemistry Letters

Biomaterials in siRNA Delivery: A Comprehensive Review

(2016) William Ho et al.   Advanced Healthcare Materials

Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy

(2016) Yan Guo et al.   PLoS One

Local administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity

(2016) Tao Tang et al.   Scientific Reports

Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury

(2015) Elizabeth Nance et al.   JOURNAL OF CONTROLLED RELEASE

Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics

(2015) Cornelia Lorenzer et al.   JOURNAL OF CONTROLLED RELEASE

Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells

(2015) Panagiotis Mastorakos et al.   Nanoscale

Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest

(2014) Manoj K. Mishra et al.   ACS Nano

Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems

(2014) Xiaoxuan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecularly Precise Dendrimer-Drug Conjugates with Tunable Drug Release for Cancer Therapy

(2014) Zhuxian Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dendrimer Advances for the Central Nervous System Delivery of Therapeutics

(2013) Leyuan Xu et al.   ACS Chemical Neuroscience

Automated method for the rapid and precise estimation of adherent cell culture characteristics from phase contrast microscopy images

(2013) Nicolas Jaccard et al.   BIOTECHNOLOGY AND BIOENGINEERING

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Challenges in Development of Nanoparticle-Based Therapeutics

(2012) Neil Desai   AAPS Journal

Dendrimers in biomedical applications—reflections on the field

(2012) Sönke Svenson et al.   ADVANCED DRUG DELIVERY REVIEWS

Glutathione-responsive nano-transporter-mediated siRNA delivery: silencing the mRNA expression of Ras

(2012) C. George Priya Doss et al.   PROTOPLASMA

Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model

(2012) S. Kannan et al.   Science Translational Medicine

Delivery of siRNA to the Mouse Lung via a Functionalized Lipopolyamine

(2011) Kevin J Polach et al.   MOLECULAR THERAPY

Strategies for In Vivo Delivery of siRNAs

(2010) Yuriko Higuchi et al.   BIODRUGS

Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model

(2010) Wim Maes et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Efficient and targeted delivery of siRNA in vivo

(2010) Min Suk Shim et al.   FEBS Journal

Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration

(2010) Hui Dai et al.   Nanomedicine

Poly(amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery

(2009) Yunus E. Kurtoglu et al.   BIOMATERIALS

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Delivery of small-interfering RNA (siRNA) to the brain

(2009) Saroj P Mathupala   EXPERT OPINION ON THERAPEUTIC PATENTS

The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine

(2009) Ashley J. Pratt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS