Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway

The Fifth Transmembrane Segment of Cystic Fibrosis Transmembrane Conductance Regulator Contributes to Its Anion Permeation Pathway

(2015) Jingyao Zhang et al.   BIOCHEMISTRY

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

(2015) Valentina Corradi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localizing a gate in CFTR

(2015) Xiaolong Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics

(2014) Jean-Paul Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metal Bridges Illuminate Transmembrane Domain Movements during Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

(2014) Yassine El Hiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR

(2014) Guiying Cui et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

(2014) A. Kodan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rates and Stoichiometries of Metal Ion Probes of Cysteine Residues within Ion Channels

(2013) Lai-Sheung Choi et al.   BIOPHYSICAL JOURNAL

Cysteine Scanning of CFTR’s First Transmembrane Segment Reveals Its Plausible Roles in Gating and Permeation

(2013) Xiaolong Gao et al.   BIOPHYSICAL JOURNAL

Functional architecture of the CFTR chloride channel

(2013) Paul Linsdell   MOLECULAR MEMBRANE BIOLOGY

Relative contribution of different transmembrane segments to the CFTR chloride channel pore

(2013) Wuyang Wang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modeling the Conformational Changes Underlying Channel Opening in CFTR

(2013) Kazi S. Rahman et al.   PLoS One

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

(2013) C. A. Shintre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystic Fibrosis Transmembrane Conductance Regulator: A Molecular Model Defines the Architecture of the Anion Conduction Path and Locates a “Bottleneck” in the Pore

(2012) Yohei Norimatsu et al.   BIOCHEMISTRY

New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation

(2012) James Dalton et al.   Journal of Chemical Information and Modeling

Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate

(2012) Sujung Ryu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(2012) Michael Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nonequilibrium Gating of CFTR on an Equilibrium Theme

(2012) Kang-Yang Jih et al.   PHYSIOLOGY

Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore

(2011) Wuyang Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)

(2011) Yonghong Bai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant

(2011) Feng Qian et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Changes in Accessibility of Cytoplasmic Substances to the Pore Associated with Activation of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

(2010) Yassine El Hiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

(2010) Yonghong Bai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore

(2009) Christopher Alexander et al.   BIOCHEMISTRY

Cadmium(II) Complex Formation with Cysteine and Penicillamine

(2009) Farideh Jalilehvand et al.   INORGANIC CHEMISTRY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating

(2008) Lihua He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CLC-0 and CFTR: Chloride Channels Evolved From Transporters

(2008) Tsung-Yu Chen et al.   PHYSIOLOGICAL REVIEWS

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

(2008) A. W. R. Serohijos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA