Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR

Cysteine Scanning of CFTR’s First Transmembrane Segment Reveals Its Plausible Roles in Gating and Permeation

(2013) Xiaolong Gao et al.   BIOPHYSICAL JOURNAL

Chloride channel-targeted therapy for secretory diarrheas

(2013) Jay R Thiagarajah et al.   CURRENT OPINION IN PHARMACOLOGY

Origin and evolution of the cystic fibrosis transmembrane regulator protein R domain

(2013) Aswathy Sebastian et al.   GENE

Two Salt Bridges Differentially Contribute to the Maintenance of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channel Function

(2013) Guiying Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling the Conformational Changes Underlying Channel Opening in CFTR

(2013) Kazi S. Rahman et al.   PLoS One

Cystic Fibrosis Transmembrane Conductance Regulator (ABCC7) Structure

(2013) J. F. Hunt et al.   Cold Spring Harbor Perspectives in Medicine

The CFTR Ion Channel: Gating, Regulation, and Anion Permeation

(2013) T.-C. Hwang et al.   Cold Spring Harbor Perspectives in Medicine

Tuning of CFTR Chloride Channel Function by Location of Positive Charges within the Pore

(2012) Yassine El Hiani et al.   BIOPHYSICAL JOURNAL

Pseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function

(2012) Man-Song Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mapping the Interaction Site for a β-Scorpion Toxin in the Pore Module of Domain III of Voltage-gated Na+Channels

(2012) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ivacaftor potentiation of multiple CFTR channels with gating mutations

(2012) Haihui Yu et al.   Journal of Cystic Fibrosis

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

(2012) Sharan K. Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions

(2012) A. Delaunay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interaction between Two Extracellular Linker Regions Controls Sustained Opening of Acid-sensing Ion Channel 1

(2011) Andreas Springauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Base of the Thumb Domain Modulates Epithelial Sodium Channel Gating

(2011) Shujie Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulfonylurea-based blockers

(2011) Guiying Cui et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mapping the receptor site for  -scorpion toxins on a Na+ channel voltage sensor

(2011) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels

(2011) K. L. Weatherall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

(2010) Yonghong Bai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore

(2009) Christopher Alexander et al.   BIOCHEMISTRY

Molecular models of the open and closed states of the whole human CFTR protein

(2009) Jean-Paul Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

(2009) Rina Glozman et al.   JOURNAL OF CELL BIOLOGY

Role of the C-Terminal Part of the Extracellular Domain of the α-ENaC in Activation by Sulfonylurea Glibenclamide

(2009) Stephane Renauld et al.   JOURNAL OF MEMBRANE BIOLOGY

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations

(2009) L. Csanady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

(2009) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces

(2008) J.-P. Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Insight toward epithelial Na+channel mechanism revealed by the acid-sensing ion channel 1 structure

(2008) James D. Stockand et al.   IUBMB LIFE

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator

(2008) X.-b. Chang et al.   JOURNAL OF CELL SCIENCE

KCNQ1 and KCNE1 in the IKsChannel Complex Make State-dependent Contacts in their Extracellular Domains

(2008) Xulin Xu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mutations at Arginine 352 Alter the Pore Architecture of CFTR

(2008) Guiying Cui et al.   JOURNAL OF MEMBRANE BIOLOGY

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore

(2008) Jing-Jun Zhou et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation

(2008) P. G. DeCaen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters

(2008) I. King Jordan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

(2008) A. W. R. Serohijos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA