IL-33 amplifies an innate immune response in the degenerating retina

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium

(2015) Matt Rutar et al.   Journal of Neuroinflammation

Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1  Secretion and Photoreceptor Neurodegeneration

(2015) S. J. Hu et al.   JOURNAL OF NEUROSCIENCE

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity

(2014) Daniel O. Villarreal et al.   CANCER RESEARCH

IL-33 attenuates the development of experimental autoimmune uveitis

(2014) Mark Barbour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

(2014) Juliana Bessa et al.   JOURNAL OF AUTOIMMUNITY

IL-33–Induced Hematopoietic Stem and Progenitor Cell Mobilization Depends upon CCR2

(2014) Juyang Kim et al.   JOURNAL OF IMMUNOLOGY

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

(2014) Steffen Durinck et al.   NATURE GENETICS

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice

(2014) A. Maeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

(2014) S. L. Doyle et al.   Science Translational Medicine

Microglia and Interleukin-1β in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A

(2013) José Carlos Rivera et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CCR2+monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation inCx3cr1deficient mice

(2013) Florian Sennlaub et al.   EMBO Molecular Medicine

Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration

(2013) Matt Rutar et al.   Journal of Neuroinflammation

Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation

(2013) Bryan Vander Lugt et al.   NATURE IMMUNOLOGY

Structural insights into the interaction of IL-33 with its receptors

(2013) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa

(2012) Congrong Guo et al.   EXPERIMENTAL EYE RESEARCH

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

Consequences of oxidative stress in age-related macular degeneration

(2012) Stuart G. Jarrett et al.   MOLECULAR ASPECTS OF MEDICINE

Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex

(2012) Imran Bhutto et al.   MOLECULAR ASPECTS OF MEDICINE

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1β Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration

(2011) Sophie Lavalette et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-33 induces skin inflammation with mast cell and neutrophil activation

(2011) Axel J. Hueber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Insights into the initiation of type 2 immune responses

(2011) Chris J. Oliphant et al.   IMMUNOLOGY

IL-33 Is Induced by Amyloid-β Stimulation and Regulates Inflammatory Cytokine Production in Retinal Pigment Epithelium Cells

(2011) Xiao-Cui Liu et al.   INFLAMMATION

Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

(2010) Jose C Alves-Filho et al.   NATURE MEDICINE

Independent filtering increases detection power for high-throughput experiments

(2010) R. Bourgon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected withToxoplasma gondii

(2009) Leigh A. Jones et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex

(2009) Q. Espinassous et al.   JOURNAL OF IMMUNOLOGY

Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects

(2009) Andreas Bringmann et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes

(2009) Andreas Lingel et al.   STRUCTURE