Loss ofEzh2synergizes withJAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis

Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes

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Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

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Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressingJAK2-V617F

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Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

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Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

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Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

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Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model

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Lethal myelofibrosis induced byBmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes

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Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

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Polycomb repressive complex 2 is required for MLL-AF9 leukemia

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Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease

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EZH2 mutational status predicts poor survival in myelofibrosis

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Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells

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New mutations and pathogenesis of myeloproliferative neoplasms

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Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

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Mouse models of myeloproliferative neoplasms: JAK of all grades

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The Polycomb complex PRC2 and its mark in life

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Clinical Effect of Point Mutations in Myelodysplastic Syndromes

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

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Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

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Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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The 2008 World Health Organization classification system for myeloproliferative neoplasms

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Lin28 promotes transformation and is associated with advanced human malignancies

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Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition

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Selective Blockade of MicroRNA Processing by Lin28

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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

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