RAG-mediated DNA double-strand breaks activate a cell type–specific checkpoint to inhibit pre–B cell receptor signals

Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia

(2015) Huimin Geng et al.   CANCER CELL

Identification of a Negative Regulatory Role for Spi-C in the Murine B Cell Lineage

(2015) Stephen K. H. Li et al.   JOURNAL OF IMMUNOLOGY

Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

(2014) Malay Haldar et al.   CELL

Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia

(2014) T. Perova et al.   Science Translational Medicine

Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

(2013) Kyoko Ochiai et al.   IMMUNITY

The Ataxia Telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondaryVκ-to-Jκrearrangements

(2013) Natalie C. Steinel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bruton's Tyrosine Kinase (BTK) and Vav1 Contribute to Dectin1-Dependent Phagocytosis of Candida albicans in Macrophages

(2013) Karin Strijbis et al.   PLoS Pathogens

The Response to and Repair of RAG-Mediated DNA Double-Strand Breaks

(2012) Beth A. Helmink et al.   Annual Review of Immunology

Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity

(2012) Jingli A. Zhang et al.   CELL

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

Regulation of B Cell Linker Protein Transcription by PU.1 and Spi-B in Murine B Cell Acute Lymphoblastic Leukemia

(2012) L. S. Xu et al.   JOURNAL OF IMMUNOLOGY

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

(2012) Kyoko Ochiai et al.   NATURE IMMUNOLOGY

The many roles of IL-7 in B cell development; Mediator of survival, proliferation and differentiation

(2012) Steven A. Corfe et al.   SEMINARS IN IMMUNOLOGY

RAG-induced DNA double-strand breaks signal through Pim2 to promote pre–B cell survival and limit proliferation

(2011) Jeffrey J. Bednarski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

(2011) Malay Mandal et al.   NATURE IMMUNOLOGY

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

(2009) Susannah L Hewitt et al.   NATURE IMMUNOLOGY

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development

(2009) Malay Mandal et al.   NATURE IMMUNOLOGY

SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage

(2008) John C. Sitko et al.   CELLULAR SIGNALLING

Redundant role for Zap70 in B cell development and activation

(2008) Farnaz Fallah-Arani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transgenic expression of Spi-C impairs B-cell development and function by affecting genes associated with BCR signaling

(2008) Xiang Zhu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Immunoglobulin Light-Chain Recombination by the Transcription Factor IRF-4 and the Attenuation of Interleukin-7 Signaling

(2008) Kristen Johnson et al.   IMMUNITY

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

(2008) Andrea L. Bredemeyer et al.   NATURE

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway

(2008) Sebastian Herzog et al.   NATURE IMMUNOLOGY

Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

(2008) Rupesh H Amin et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY