STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer
Authors
Keywords
-
Journal
Life Science Alliance
Volume 5, Issue 11, Pages e202201460
Publisher
Life Science Alliance, LLC
Online
2022-07-09
DOI
10.26508/lsa.202201460
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Therapeutic Manipulation of Tumor-associated Macrophages: Facts and Hopes from a Clinical and Translational Perspective
- (2021) Paola Allavena et al. CLINICAL CANCER RESEARCH
- Therapeutic targeting of STAT3 pathways in pancreatic adenocarcinoma: A systematic review of clinical and preclinical literature
- (2021) Sarah Peisl et al. PLoS One
- Interactions between Cancer-Associated Fibroblasts and T Cells in the Pancreatic Tumor Microenvironment and the Role of Chemokines
- (2021) Laia Gorchs et al. Cancers
- Role of IL-6 in the commitment of T cell subsets
- (2021) Thomas Korn et al. CYTOKINE
- The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer Growth
- (2021) Paul Manoukian et al. Frontiers in Cell and Developmental Biology
- Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer
- (2020) Austin R. Dosch et al. MOLECULAR CANCER RESEARCH
- Emerging role of PTEN loss in evasion of the immune response to tumours
- (2020) Thiago Vidotto et al. BRITISH JOURNAL OF CANCER
- Targeting STAT3 in Cancer Immunotherapy
- (2020) Sailan Zou et al. Molecular Cancer
- Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment
- (2019) Makoto Sano et al. Oncogenesis
- Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features
- (2019) Eva Karamitopoulou BRITISH JOURNAL OF CANCER
- TAMing pancreatic cancer: combat with a double edged sword
- (2019) Manendra Babu Lankadasari et al. Molecular Cancer
- Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
- (2019) Ela Elyada et al. Cancer Discovery
- Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages
- (2019) Marco Orecchioni et al. Frontiers in Immunology
- Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
- (2019) Tongyan Liu et al. Journal of Hematology & Oncology
- Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy
- (2019) Claudia X Dominguez et al. Cancer Discovery
- Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy
- (2018) Jinyang Li et al. IMMUNITY
- Stromal PTEN determines mammary epithelial response to radiotherapy
- (2018) Gina M. Sizemore et al. Nature Communications
- PTEN: Tumor Suppressor and Metabolic Regulator
- (2018) Chien-Yu Chen et al. Frontiers in Endocrinology
- The Paradoxical Web of Pancreatic Cancer Tumor Microenvironment
- (2018) Kelly J. Lafaro et al. AMERICAN JOURNAL OF PATHOLOGY
- IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma
- (2018) Giulia Biffi et al. Cancer Discovery
- Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland
- (2018) Caitlin E. Jones et al. NEOPLASIA
- Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
- (2017) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele
- (2017) Jinghai Wu et al. PLoS One
- JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer
- (2017) Chunwan Lu et al. OncoImmunology
- Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia
- (2016) Xin Liu et al. GENES & DEVELOPMENT
- IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer
- (2016) Thomas A Mace et al. GUT
- Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection
- (2016) Cole R. Drifka et al. Oncotarget
- Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia
- (2016) Jason R. Pitarresi et al. NEOPLASIA
- Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer
- (2015) Nagaraj S. Nagathihalli et al. GASTROENTEROLOGY
- An analysis of critical factors for quantitative immunoblotting
- (2015) Kevin A. Janes Science Signaling
- MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
- (2015) D. G. Nowak et al. Cancer Discovery
- An analysis of critical factors for quantitative immunoblotting
- (2015) Kevin A. Janes Science Signaling
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
- (2014) Mara H. Sherman et al. CELL
- Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer
- (2013) Y Ino et al. BRITISH JOURNAL OF CANCER
- PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line
- (2013) SEOK-HO MOON et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The IL-6 Trans-Signaling-STAT3 Pathway Mediates ECM and Cellular Proliferation in Fibroblasts from Hypertrophic Scar
- (2013) Sutapa Ray et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Unraveling the therapeutic potential of the Hedgehog pathway in cancer
- (2013) Dereck Amakye et al. NATURE MEDICINE
- Abstract 5020: Potential lifestyle intervention in inner city women with endometrial cancer: A pilot study
- (2012) Nicole S. Nevadunsky et al. CANCER RESEARCH
- Emerging inorganic nanomaterials for pancreatic cancer diagnosis and treatment
- (2012) Feng Yang et al. CANCER TREATMENT REVIEWS
- The JAK-STAT Pathway at Twenty
- (2012) George R. Stark et al. IMMUNITY
- Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
- (2012) Julie R. Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3
- (2011) Olga A. Guryanova et al. CANCER CELL
- Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320
- (2011) A. Bronisz et al. NATURE CELL BIOLOGY
- Essential role of Stat3 in PI3K-induced oncogenic transformation
- (2011) Jonathan R. Hart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PI3K and STAT3: A New Alliance
- (2011) P. K. Vogt et al. Cancer Discovery
- Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma
- (2010) Richard E. Royal et al. JOURNAL OF IMMUNOTHERAPY
- Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver
- (2010) C. H. Osterreicher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy
- (2010) S. Sarma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pten in stromal fibroblasts suppresses mammary epithelial tumours
- (2009) Anthony J. Trimboli et al. NATURE
- Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer
- (2008) A. J. Trimboli et al. CANCER RESEARCH
- CXCL8/IL-8 and CXCL12/SDF-1α co-operatively promote invasiveness and angiogenesis in pancreatic cancer
- (2008) Yoichi Matsuo et al. INTERNATIONAL JOURNAL OF CANCER
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started