Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features
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Title
Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features
Authors
Keywords
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Journal
BRITISH JOURNAL OF CANCER
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-05-21
DOI
10.1038/s41416-019-0479-5
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Note: Only part of the references are listed.- Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma
- (2018) Philipp Lohneis et al. BRITISH JOURNAL OF CANCER
- The Immune Revolution: A Case for Priming, Not Checkpoint
- (2018) Robert H. Vonderheide CANCER CELL
- Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations
- (2018) Zishuo I. Hu et al. CLINICAL CANCER RESEARCH
- Integrated genomic and immunophenotypic classification of pancreatic cancer reveals three distinct subtypes with prognostic/predictive significance
- (2018) Martin Wartenberg et al. CLINICAL CANCER RESEARCH
- A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune Cell Populations
- (2018) David Tamborero et al. CLINICAL CANCER RESEARCH
- Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas
- (2018) Renato M. Lupinacci et al. GASTROENTEROLOGY
- Involvement of partial EMT in cancer progression
- (2018) Masao Saitoh JOURNAL OF BIOCHEMISTRY
- MiR200 and miR302: Two Big Families Influencing Stem Cell Behavior
- (2018) Francesca Balzano et al. MOLECULES
- Update on Tumor Neoantigens and Their Utility: Why It Is Good to Be Different
- (2018) Chung-Han Lee et al. TRENDS IN IMMUNOLOGY
- Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
- (2018) Daniel J. McGrail et al. Nature Communications
- Immunotherapy for Pancreatic Cancer: More Than Just a Gut Feeling
- (2018) Erick Riquelme et al. Cancer Discovery
- Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
- (2018) Hervé Tiriac et al. Cancer Discovery
- CSF1R + Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype
- (2018) Juliana B. Candido et al. Cell Reports
- Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors
- (2018) Aaron M. Goodman et al. JAMA Oncology
- Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma
- (2018) Zhi Rong Qian et al. JAMA Oncology
- Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
- (2018) Rikke B. Holmgaard et al. Journal for ImmunoTherapy of Cancer
- Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes?
- (2018) Brooke Paradise et al. Cancers
- Advances in Molecular Profiling and Categorisation of Pancreatic Adenocarcinoma and the Implications for Therapy
- (2018) Rille Pihlak et al. Cancers
- Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy
- (2018) Neus Martinez-Bosch et al. Cancers
- Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes
- (2018) Sebastian Mueller et al. NATURE
- Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features
- (2018) Francesco Puleo et al. GASTROENTEROLOGY
- Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial
- (2017) John P Neoptolemos et al. LANCET
- MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer
- (2017) Eva Karamitopoulou et al. MODERN PATHOLOGY
- Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
- (2017) Vinod P. Balachandran et al. NATURE
- MicroRNA-200b is downregulated in colon cancer budding cells
- (2017) Kirsten Nguyen Knudsen et al. PLoS One
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- DNA profiling of tumor buds in colorectal cancer indicates that they have the same mutation profile as the tumor from which they derive
- (2017) Irene Centeno et al. VIRCHOWS ARCHIV
- Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
- (2017) Julienne L. Carstens et al. Nature Communications
- Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma
- (2017) Ashton A. Connor et al. JAMA Oncology
- The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance
- (2017) Sunjida Ahmed et al. Journal of Clinical Medicine
- Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching
- (2016) Linde De Smedt et al. BRITISH JOURNAL OF CANCER
- CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
- (2016) Colin W. Steele et al. CANCER CELL
- Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell–Rich Tumor
- (2016) Shin Foong Ngiow et al. CANCER RESEARCH
- Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability
- (2016) Bernhard Mlecnik et al. IMMUNITY
- Genomic analyses identify molecular subtypes of pancreatic cancer
- (2016) Peter Bailey et al. NATURE
- CD40-activated B cells induce anti-tumor immunity in vivo
- (2016) Kerstin Wennhold et al. Oncotarget
- CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer
- (2016) Katelyn T. Byrne et al. Cell Reports
- Tumor Budding: The Name is EMT. Partial EMT.
- (2016) Alexandru Grigore et al. Journal of Clinical Medicine
- Tumor Budding Is an Independent Adverse Prognostic Factor in Pancreatic Ductal Adenocarcinoma
- (2015) Kate O’Connor et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer
- (2015) J A Galván et al. BRITISH JOURNAL OF CANCER
- Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma
- (2015) Ilona Kohler et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
- (2015) Richard A Moffitt et al. NATURE GENETICS
- Addressing the challenges of pancreatic cancer: Future directions for improving outcomes
- (2015) Manuel Hidalgo et al. PANCREATOLOGY
- Targeting the TGFβ pathway for cancer therapy
- (2015) Cindy Neuzillet et al. PHARMACOLOGY & THERAPEUTICS
- Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma
- (2015) Martin Wartenberg et al. Oncotarget
- Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma
- (2015) Giovanni Francesco Castino et al. OncoImmunology
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
- (2014) L. Rahib et al. CANCER RESEARCH
- CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models
- (2014) Y. Zhu et al. CANCER RESEARCH
- Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies
- (2014) Jonathan Haqq et al. EUROPEAN JOURNAL OF CANCER
- Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
- (2014) Limo Chen et al. Nature Communications
- Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy
- (2014) Eric R Lutz et al. OncoImmunology
- Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
- (2013) Abasi Ene–Obong et al. GASTROENTEROLOGY
- MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression
- (2013) Adam E. Frampton et al. GASTROENTEROLOGY
- K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
- (2013) Jonathan M. Ostrem et al. NATURE
- T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis
- (2012) A. Facciabene et al. CANCER RESEARCH
- Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness
- (2012) Enza Lonardo et al. CELL CYCLE
- Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors
- (2012) S. Yachida et al. CLINICAL CANCER RESEARCH
- Tumour budding is a strong and independent prognostic factor in pancreatic cancer
- (2012) E. Karamitopoulou et al. EUROPEAN JOURNAL OF CANCER
- Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
- (2012) Michael A Jacobetz et al. GUT
- Network of WNT and Other Regulatory Signaling Cascades in Pluripotent Stem Cells and Cancer Stem Cells
- (2011) Masaru Katoh CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
- (2011) Eric A Collisson et al. NATURE MEDICINE
- Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations
- (2011) S Floor et al. ONCOGENE
- CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer
- (2010) Naoki Ikenaga et al. GASTROENTEROLOGY
- EMT: When epithelial cells decide to become mesenchymal-like cells
- (2009) Raghu Kalluri JOURNAL OF CLINICAL INVESTIGATION
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