Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic
Authors
Keywords
DNA damage response, PARP enzymes, PARP inhibitors, Cancer, BRCA1/2 and BRCAness, Clinical trials, Assays, HR proficiency and PARP activity
Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 35, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-11-25
DOI
10.1186/s13046-016-0456-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- First-in-human trial of a poly(ADP-ribose) polymerase (PARP) inhibitor MK-4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers.
- (2017) S. K. Sandhu et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II trial of the poly(ADP-ribose) polymerase (PARP) inhibitor AG-014699 in BRCA 1 and 2–mutated, advanced ovarian and/or locally advanced or metastatic breast cancer.
- (2017) Y. Drew et al. JOURNAL OF CLINICAL ONCOLOGY
- Evaluation of the methods to identify patients who may benefit from PARP inhibitor use
- (2016) Diana Lim et al. ENDOCRINE-RELATED CANCER
- Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics
- (2015) Michael O. Hottiger Annual Review of Biochemistry
- Prevalence of BRCA1 and BRCA2 germline mutations in patients with triple-negative breast cancer
- (2015) Michelle W. Wong-Brown et al. BREAST CANCER RESEARCH AND TREATMENT
- Identification of germline genetic mutations in patients with pancreatic cancer
- (2015) Erin E. Salo-Mullen et al. CANCER
- Integrative Clinical Genomics of Advanced Prostate Cancer
- (2015) Dan Robinson et al. CELL
- The structural basis of XRCC1-mediated DNA repair
- (2015) Robert E. London DNA REPAIR
- The role of germline mutations in the BRCA1/2 and mismatch repair genes in men ascertained for early-onset and/or familial prostate cancer
- (2015) Sofia Maia et al. Familial Cancer
- Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination
- (2015) Philip Jones et al. JOURNAL OF MEDICINAL CHEMISTRY
- PARP inhibitors: A new era of targeted therapy
- (2015) Shifalika Tangutoori et al. MATURITAS
- RNA Regulation by Poly(ADP-Ribose) Polymerases
- (2015) Florian J. Bock et al. MOLECULAR CELL
- Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance
- (2015) Peter Bai MOLECULAR CELL
- Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation
- (2015) Eva Barkauskaite et al. MOLECULAR CELL
- Whole–genome characterization of chemoresistant ovarian cancer
- (2015) Ann-Marie Patch et al. NATURE
- Whole genomes redefine the mutational landscape of pancreatic cancer
- (2015) Nicola Waddell et al. NATURE
- DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
- (2015) Joaquin Mateo et al. NEW ENGLAND JOURNAL OF MEDICINE
- FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC
- (2015) Francesco Morra et al. Oncotarget
- DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining
- (2015) Sean M. Howard et al. PLoS Genetics
- Doubling Down on the PI3K-AKT-mTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness
- (2015) Pradip De et al. NEOPLASIA
- Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide
- (2014) Lucio Tentori et al. BMC CANCER
- Assessing the function of homologous recombination DNA repair in malignant pleural effusion (MPE) samples
- (2014) M J Patterson et al. BRITISH JOURNAL OF CANCER
- Mismatch repair genes founder mutations and cancer susceptibility in Lynch syndrome
- (2014) G. Ponti et al. CLINICAL GENETICS
- DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
- (2014) Anthony J. Davis et al. DNA REPAIR
- New therapeutic perspectives in CCDC6 deficient lung cancer cells
- (2014) Francesco Morra et al. INTERNATIONAL JOURNAL OF CANCER
- Bloom syndrome
- (2014) Harleen Arora et al. INTERNATIONAL JOURNAL OF DERMATOLOGY
- Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors
- (2014) Poorval M. Joshi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase III Study of Iniparib Plus Gemcitabine and Carboplatin Versus Gemcitabine and Carboplatin in Patients With Metastatic Triple-Negative Breast Cancer
- (2014) Joyce O'Shaughnessy et al. JOURNAL OF CLINICAL ONCOLOGY
- Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity
- (2014) Tamara Fernández-Marcelo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Downfall of Iniparib: A PARP Inhibitor That Doesn't Inhibit PARP After All
- (2014) G. Sinha JNCI-Journal of the National Cancer Institute
- Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark
- (2014) Niraj Lodhi et al. NUCLEIC ACIDS RESEARCH
- Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program:PALB2mutation predicts exceptionalin vivoresponse to BMN 673
- (2014) Malcolm A. Smith et al. PEDIATRIC BLOOD & CANCER
- The Use of Ovarian Cancer Cells from Patients Undergoing Surgery to Generate Primary Cultures Capable of Undergoing Functional Analysis
- (2014) Rachel L. O′Donnell et al. PLoS One
- A Genomic Instability Score in Discriminating Nonequivalent Outcomes of BRCA1/2 Mutations and in Predicting Outcomes of Ovarian Cancer Treated with Platinum-Based Chemotherapy
- (2014) Shaojun Zhang et al. PLoS One
- Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention
- (2014) F. J. Couch et al. SCIENCE
- Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer
- (2013) J. D. Steffen et al. CANCER RESEARCH
- Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
- (2013) I. Bajrami et al. CANCER RESEARCH
- BMN 673, a Novel and Highly Potent PARP1/2 Inhibitor for the Treatment of Human Cancers with DNA Repair Deficiency
- (2013) Y. Shen et al. CLINICAL CANCER RESEARCH
- Identification of miRNA modulators to PARP inhibitor response
- (2013) Sari Neijenhuis et al. DNA REPAIR
- Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies
- (2013) T. J. Gaymes et al. HAEMATOLOGICA
- Breast cancer susceptibility gene 1 (BRCA1) predict clinical outcome in platinum- and toxal-based chemotherapy in non-small-cell lung cancer (NSCLC) patients: a system review and meta-analysis
- (2013) Yanlong Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition
- (2013) Maria Gilardini Montani et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
- (2013) Shahneen K Sandhu et al. LANCET ONCOLOGY
- PARP-1 and gene regulation: Progress and puzzles
- (2013) W. Lee Kraus et al. MOLECULAR ASPECTS OF MEDICINE
- Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib
- (2013) J. Murai et al. MOLECULAR CANCER THERAPEUTICS
- The causes and consequences of genetic heterogeneity in cancer evolution
- (2013) Rebecca A. Burrell et al. NATURE
- Causes and consequences of replication stress
- (2013) Michelle K. Zeman et al. NATURE CELL BIOLOGY
- Appraising iniparib, the PARP inhibitor that never was—what must we learn?
- (2013) Joaquin Mateo et al. Nature Reviews Clinical Oncology
- A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer
- (2013) S Postel-Vinay et al. ONCOGENE
- Acute Lymphoblastic Leukemia in Early Childhood as the Presenting Sign of Ataxia-Telangiectasia Variant
- (2013) Bella Bielorai et al. PEDIATRIC HEMATOLOGY AND ONCOLOGY
- High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival
- (2013) Lars O. Baumbusch et al. PLoS One
- Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair
- (2013) M. Robu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Potential of the Synthetic Lethality Principle
- (2013) S. M. B. Nijman et al. SCIENCE
- Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress
- (2013) C. Bassi et al. SCIENCE
- Palliative systemic therapy for women with recurrent epithelial ovarian cancer: current options
- (2013) Laurie Elit et al. OncoTargets and Therapy
- Beyond DNA Repair: Additional Functions of PARP-1 in Cancer
- (2013) Alice N. Weaver et al. Frontiers in Oncology
- The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art
- (2012) Mike De Vos et al. BIOCHEMICAL PHARMACOLOGY
- Advances in using PARP inhibitors to treat cancer
- (2012) Shivaani Kummar et al. BMC Medicine
- Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
- (2012) V Abkevich et al. BRITISH JOURNAL OF CANCER
- PARP-1 Inhibition as a Targeted Strategy to Treat Ewing's Sarcoma
- (2012) J. C. Brenner et al. CANCER RESEARCH
- Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
- (2012) J. Murai et al. CANCER RESEARCH
- Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation
- (2012) T. Popova et al. CANCER RESEARCH
- PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells
- (2012) H. Cheng et al. CARCINOGENESIS
- Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein
- (2012) Magdolna Szántó et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Therapeutic strategies in epithelial ovarian cancer
- (2012) Ayako Kim et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Combined analysis of mRNA expression of ERCC1, BAG-1, BRCA1, RRM1 and TUBB3 to predict prognosis in patients with non-small cell lung cancer who received adjuvant chemotherapy
- (2012) Xue-Feng Leng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Secondary mutations inBRCA2associated with clinical resistance to a PARP inhibitor
- (2012) Louise J Barber et al. JOURNAL OF PATHOLOGY
- Systematic identification of genomic markers of drug sensitivity in cancer cells
- (2012) Mathew J. Garnett et al. NATURE
- The DNA damage response and cancer therapy
- (2012) Christopher J. Lord et al. NATURE
- Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
- (2012) Jenna L. Riffell et al. NATURE REVIEWS DRUG DISCOVERY
- Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
- (2012) Jonathan Ledermann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting DNA repair mechanisms in cancer
- (2012) John M. Furgason et al. PHARMACOLOGY & THERAPEUTICS
- Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage
- (2012) Francesco Merolla et al. PLoS One
- Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents
- (2012) Wenrui Duan et al. Translational Research
- Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents
- (2012) Nicolai J. Birkbak et al. Cancer Discovery
- Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer
- (2011) J. Chad Brenner et al. CANCER CELL
- Searching for synthetic lethality in cancer
- (2011) Rachel Brough et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
- (2011) S. E. Polo et al. GENES & DEVELOPMENT
- Platinum resistance in breast and ovarian cancer cell lines
- (2011) Niels Eckstein JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
- (2011) Karen A Gelmon et al. LANCET ONCOLOGY
- The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
- (2011) Thomas Helleday Molecular Oncology
- Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
- (2011) Neil Johnson et al. NATURE MEDICINE
- The MRE11 complex: starting from the ends
- (2011) Travis H. Stracker et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer
- (2011) Joyce O'Shaughnessy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Molecular mechanisms of cisplatin resistance
- (2011) L Galluzzi et al. ONCOGENE
- RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis
- (2011) Natsuko Suwaki et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Temozolomide: Mechanisms of Action, Repair and Resistance
- (2011) Jihong Zhang et al. Current Molecular Pharmacology
- BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations
- (2010) Henne Holstege et al. BMC CANCER
- DNA repair signature is associated with anthracycline response in triple negative breast cancer patients
- (2010) A. A. Rodriguez et al. BREAST CANCER RESEARCH AND TREATMENT
- Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis
- (2010) Anthony Gonçalves et al. BREAST CANCER RESEARCH AND TREATMENT
- Model-based prediction of defective DNA mismatch repair using clinicopathological variables in sporadic colon cancer patients
- (2010) Frank Sinicrope et al. CANCER
- Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells
- (2010) P. Gottipati et al. CANCER RESEARCH
- PTEN Loss Compromises Homologous Recombination Repair in Astrocytes: Implications for Glioblastoma Therapy with Temozolomide or Poly(ADP-Ribose) Polymerase Inhibitors
- (2010) B. McEllin et al. CANCER RESEARCH
- Reduced DNA Repair Capacity for Removing Tobacco Carcinogen-Induced DNA Adducts Contributes to Risk of Head and Neck Cancer but not Tumor Characteristics
- (2010) L.-E Wang et al. CLINICAL CANCER RESEARCH
- Histone H2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers
- (2010) C. E. Redon et al. CLINICAL CANCER RESEARCH
- Poly(ADP-Ribose) Polymerase Inhibition: "Targeted" Therapy for Triple-Negative Breast Cancer
- (2010) C. K. Anders et al. CLINICAL CANCER RESEARCH
- A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer
- (2010) M. Graeser et al. CLINICAL CANCER RESEARCH
- Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors
- (2010) A. Mukhopadhyay et al. CLINICAL CANCER RESEARCH
- THE RABIT: A RAPID AUTOMATED BIODOSIMETRY TOOL FOR RADIOLOGICAL TRIAGE
- (2010) Guy Garty et al. HEALTH PHYSICS
- Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair
- (2010) Timothy D. Wiltshire et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gene Expression Profile ofBRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer
- (2010) Panagiotis A. Konstantinopoulos et al. JOURNAL OF CLINICAL ONCOLOGY
- Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses inBRCACarrier Ovarian Cancer Correlating With Platinum-Free Interval
- (2010) Peter C. Fong et al. JOURNAL OF CLINICAL ONCOLOGY
- The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis
- (2010) Lin-Bo Gao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial
- (2010) Andrew Tutt et al. LANCET
- The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
- (2010) Raga Krishnakumar et al. MOLECULAR CELL
- Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
- (2010) Jie Liu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination
- (2010) Rémi Buisson et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods
- (2010) L. V. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors
- (2010) K. J. Dedes et al. Science Translational Medicine
- Targeting homologous recombination repair defects in cancer
- (2010) Bastiaan Evers et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines
- (2009) T Zaremba et al. BRITISH JOURNAL OF CANCER
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
- (2009) Ji Luo et al. CELL
- In vitro and In vivo Radiosensitization of Glioblastoma Cells by the Poly (ADP-Ribose) Polymerase Inhibitor E7016
- (2009) A. L. Russo et al. CLINICAL CANCER RESEARCH
- PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
- (2009) Helen E Bryant et al. EMBO JOURNAL
- Synthetic lethal targeting ofPTENmutant cells with PARP inhibitors
- (2009) Ana M. Mendes-Pereira et al. EMBO Molecular Medicine
- Poly(ADP-ribose) polymerase inhibitors in cancer treatment: A clinical perspective
- (2009) Shahneen K. Sandhu et al. EUROPEAN JOURNAL OF CANCER
- Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies
- (2009) Shivaani Kummar et al. JOURNAL OF CLINICAL ONCOLOGY
- Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck
- (2009) Michal Kowalski et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies
- (2009) H. Willers et al. MOLECULAR CANCER RESEARCH
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- High throughput evaluation of gamma-H2AX
- (2009) Dane Avondoglio et al. Radiation Oncology
- An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors
- (2008) Xuesong Liu et al. ANALYTICAL BIOCHEMISTRY
- Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts
- (2008) R. J. Kinders et al. CLINICAL CANCER RESEARCH
- Phase I Study of the Poly(ADP-Ribose) Polymerase Inhibitor, AG014699, in Combination with Temozolomide in Patients with Advanced Solid Tumors
- (2008) R. Plummer et al. CLINICAL CANCER RESEARCH
- DNA repair deficiency as a therapeutic target in cancer
- (2008) Sarah A Martin et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Targeted therapy for cancer using PARP inhibitors
- (2008) Christopher J Lord et al. CURRENT OPINION IN PHARMACOLOGY
- A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity
- (2008) Christopher J. Lord et al. DNA REPAIR
- A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
- (2008) Nicholas C Turner et al. EMBO JOURNAL
- The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series
- (2008) Antoinette Hakmé et al. EMBO REPORTS
- Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice
- (2008) Jian Zou et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
- (2008) Wataru Sakai et al. NATURE
- Resistance to therapy caused by intragenic deletion in BRCA2
- (2008) Stacey L. Edwards et al. NATURE
- An Oncogene-Induced DNA Damage Model for Cancer Development
- (2008) T. D. Halazonetis et al. SCIENCE
- The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
- (2007) Paul et al. Frontiers in Bioscience-Landmark
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started