Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein

Poly(ADP-Ribose) Polymerases PARP1 and PARP2 Modulate Topoisomerase II Beta (TOP2B) Function During Chromatin Condensation in Mouse Spermiogenesis1

(2011) Mirella L. Meyer-Ficca et al.   BIOLOGY OF REPRODUCTION

Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction

(2011) Magdolna Szántó et al.   CARDIOVASCULAR RESEARCH

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

(2011) Péter Bai et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Identification of candidate substrates for poly(ADP-ribose) polymerase-2 (PARP2) in the absence of DNA damage using high-density protein microarrays

(2011) Sonia Troiani et al.   FEBS Journal

Effect of Polyphenols on Oxidative Stress and Mitochondrial Dysfunction in Neuronal Death and Brain Edema in Cerebral Ischemia

(2011) Kiran S. Panickar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

(2011) Yi Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

(2011) Kahlilia C Morris et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)

(2011) Peter T. Sunderland et al.   JOURNAL OF MEDICINAL CHEMISTRY

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

(2011) C. Boehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitomycin C modulates DNA-double strand break repair genes in cervical carcinoma cells

(2010) Yun Hee Kang et al.   AMINO ACIDS

Crystal Structure of the Catalytic Domain of Human PARP2 in Complex with PARP Inhibitor ABT-888

(2010) Tobias Karlberg et al.   BIOCHEMISTRY

Integrated genomics of susceptibility to alkylator-induced leukemia in mice

(2010) Patrick Cahan et al.   BMC GENOMICS

Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation

(2010) Zhiyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Ablation of PARP-1 Protects Against Oxazolone-Induced Contact Hypersensitivity by Modulating Oxidative Stress

(2010) Attila Brunyánszki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia

(2010) Xiaoling Li et al.   JOURNAL OF NEUROCHEMISTRY

Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice

(2010) L Nicolás et al.   ONCOGENE

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

(2010) Maxim Isabelle et al.   Proteome Science

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondria, oxidative metabolism and cell death in stroke

(2009) Neil R. Sims et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage

(2009) F Moroni et al.   BRITISH JOURNAL OF PHARMACOLOGY

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Parp2 is required for the differentiation of post-meiotic germ cells: Identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2

(2009) Delphine Quénet et al.   EXPERIMENTAL CELL RESEARCH

Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway

(2009) Elizabeth D. Brookins Danz et al.   FREE RADICAL BIOLOGY AND MEDICINE

PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases

(2009) Andreína Peralta-Leal et al.   FREE RADICAL BIOLOGY AND MEDICINE

LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrest

(2009) Naoko Sakugawa et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

(2009) Isabelle Robert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

(2009) Matthias Altmeyer et al.   NUCLEIC ACIDS RESEARCH

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

(2008) Sandra S Haenni et al.   BMC CELL BIOLOGY

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

On the Way to Selective PARP-2 Inhibitors. Design, Synthesis, and Preliminary Evaluation of a Series of Isoquinolinone Derivatives

(2008) Roberto Pellicciari et al.   ChemMedChem

The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1β and the heterochromatin protein HP1α

(2008) Delphine Quénet et al.   FASEB JOURNAL

Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns

(2008) Paola Caiafa et al.   FASEB JOURNAL

Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation

(2008) Rajesh Jha et al.   FERTILITY AND STERILITY

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation

(2008) Sandra S. Haenni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The role of poly(ADP-ribosyl)ation in epigenetic events

(2008) Delphine Quénet et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation

(2008) Nirmal K. Phulwani et al.   JOURNAL OF NEUROCHEMISTRY

Substrate-Assisted Catalysis by PARP10 Limits Its Activity to Mono-ADP-Ribosylation

(2008) Henning Kleine et al.   MOLECULAR CELL

Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

(2008) R. Krishnakumar et al.   SCIENCE

Toward specific functions of poly(ADP-ribose) polymerase-2

(2008) José Yélamos et al.   TRENDS IN MOLECULAR MEDICINE