Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2

Activation of IL-8 via PI3K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells

(2015) Lin Wang et al.   CANCER BIOLOGY & THERAPY

Abstract 1254: Mitochondrial SOD2 regulates EMT and cancer stem cell-like cell populations

(2015) Kelly A. Whelan et al.   CANCER RESEARCH

Unraveling the TWIST between EMT and Cancer Stemness

(2015) Hae-Yun Jung et al.   Cell Stem Cell

Ubiquitin specific protease 2 acts as a key modulator for the regulation of cell cycle by adiponectin and leptin in cancer cells

(2015) Saroj Nepal et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis

(2015) Saroj Nepal et al.   Oncotarget

Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways

(2015) Li Yang et al.   Oncotarget

PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EGFR Activation

(2014) Fang-Tian Fan et al.   Asian Pacific Journal of Cancer Prevention

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition

(2014) A. Hamabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-surrounding adipocytes are active players in breast cancer progression

(2013) Catherine Muller   ANNALES D ENDOCRINOLOGIE

TACC3 promotes epithelial–mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways

(2013) Geun-Hyoung Ha et al.   CANCER LETTERS

Regulation and function of pyruvate kinase M2 in cancer

(2013) Weiwei Yang et al.   CANCER LETTERS

Leptin–cytokine crosstalk in breast cancer

(2013) Gale Newman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

(2013) Yuhui Jiang et al.   MOLECULAR CELL

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

Par-4 downregulation confers cisplatin resistance in pancreatic cancer cells via PI3K/Akt pathway-dependent EMT

(2013) Jiaxin Tan et al.   TOXICOLOGY LETTERS

Adipokine leptin in obesity-related pathology of breast cancer

(2012) Amitabha Ray   JOURNAL OF BIOSCIENCES

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

(2011) Mark A. Eckert et al.   CANCER CELL

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Leptin and breast cancer: an overview

(2011) Mehmet Artac et al.   MEDICAL ONCOLOGY

Obesity and breast cancer: status of leptin and adiponectin in pathological processes

(2010) Michael E. Grossmann et al.   CANCER AND METASTASIS REVIEWS

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

(2007) Jungwoon Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY