Journal
ANNALES D ENDOCRINOLOGIE
Volume 74, Issue 2, Pages 108-110Publisher
MASSON EDITEUR
DOI: 10.1016/j.ando.2013.02.007
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Accumulating recent evidence highlights the tumour-surrounding adipose tissue as a key component of breast cancer progression. We have recently demonstrated that a bidirectional crosstalk is established with breast cancer cells and tumour-surrounding adipocytes. Tumour cell secretions are able to modify tumour-surrounding adipocytes to an activated state that we have named Cancer-Associated Adipocytes (CAAs). The role of CAAs in breast cancer progression, as well as the potential amplification of this negative effect in obesity conditions will be discussed. (C) 2013 Elsevier Masson SAS. All rights reserved.
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