Article
Biochemistry & Molecular Biology
Betul Unlu, Begum Kocaturk, Araci M. R. Rondon, Clayton S. Lewis, Nathalie Swier, Rob F. P. van den Akker, Danielle Krijgsman, Iris Noordhoek, Erik J. Blok, Vladimir Y. Bogdanov, Wolfram Ruf, Peter J. K. Kuppen, Henri H. Versteeg
Summary: TF expression in breast cancer is associated with metastasis and cancer stemness, blockade of TF signaling can inhibit metastasis and reduce expression of pro-metastatic markers.
Article
Pharmacology & Pharmacy
Mehrdokht Sadrkhanloo, Maliheh Entezari, Sima Orouei, Marzieh Ghollasi, Nikoo Fathi, Shamin Rezaei, Elahe Sadat Hejazi, Amirabbas Kakavand, Hamidreza Saebfar, Mehrdad Hashemi, Mohammad Ali Sheikh Beig Goharrizi, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Saeed Samarghandian
Summary: Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for tumor metastasis and inhibition of this process improves prognosis. STAT3 signaling is shown to promote EMT-mediated cancer migration and invasion, and its inhibition suppresses cancer metastasis and improves therapy response.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xinrui Zhao, Xinglong Liu, Songling Hu, Yan Pan, Jianghong Zhang, Guomei Tai, Chunlin Shao
Summary: Radiotherapy is a conventional treatment method for breast cancer, but radioresistance affects the prognosis negatively. This study found that the GDF15 gene is related to poor prognosis in breast cancer patients after radiotherapy. Breast cancer cells with acquired radioresistance showed high expression of GDF15 and enhanced properties of epithelial-to-mesenchymal transition (EMT) and stemness. Knockdown of GDF15 sensitized radioresistant cells to irradiation and inhibited their EMT and stemness properties. GDF15 may serve as a prognosis-related biomarker and a potential therapeutic target for breast cancer radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jeroen Verstappe, Geert Berx
Summary: Stem cells have the ability to self-renew and give rise to differentiated cells, playing important roles in maintaining tissue homeostasis and injury repair. Cancer stem cells, which exhibit stem-like properties, are responsible for tumor growth, metastasis, and relapse. The process of epithelial-to-mesenchymal transition (EMT) is correlated with stemness in both normal and cancer cells, indicating the acquisition of stemness is not intrinsic. Recent studies show that hybrid EMT states have a higher likelihood of acquiring stem cell traits. The position of a cell along the EMT axis, known as the stemness window, determines the EMT/MET inducing programs required to reach stemness.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Pathology
Chuntao Tian, Ying Liu, Yixiong Liu, Peizhen Hu, Shenglong Xie, Yu Guo, Hui Wang, Zhiyong Zhang, Liuyang Du, Binhua Lei, Yingping Wang, Lingfei Xue, Dong Zhang, Jing Su, Xiaotong Zhang, Ruiwen Zhang, Jiaohong Chen, Xiangqian Zhang, Ligang Chen, Mingyang Li, Qingge Jia, Junyang Song, Jin Liu
Summary: The study found that UCHL1 was overexpressed in TNBC tissues and was associated with poor prognosis. UCHL1 promoted cancer stemness and enhanced the migration and invasion ability of TNBC cells. These findings suggest that UCHL1 may play a crucial role in the malignant progression of TNBC and could be a potential therapeutic target for TNBC patients.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Poyil Pratheeshkumar, Abdul K. Siraj, Sasidharan Padmaja Divya, Sandeep Kumar Parvathareddy, Khadija Alobaisi, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: CHD4 is highly expressed in PTC and associated with aggressive disease parameters and poor prognosis. Overexpression of CHD4 promotes proliferation, migration, invasion, and EMT progression in PTC cells, while its knockdown inhibits these processes. CHD4 might be a potential therapeutic target in patients with PTC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Shiqi Wu, Yangyang Yue, Yanan Gu, Qi Wang, Tianjie Liu, Lei Li, Xinyang Wang, Luke S. Chang, Dalin He, Kaijie Wu
Summary: MUC15 acts as a novel tumor suppressor in prostate cancer, inhibiting metastasis by modulating epithelial-mesenchymal transition and cancer stemness.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Cindy Van Branteghem, Alice Augenlicht, Pieter Demetter, Ligia Craciun, Carine Maenhaut
Summary: Thyroid cancer is a common endocrine malignant tumor with increasing incidence. This study focused on miR-204-5p, which is downregulated in aggressive papillary thyroid carcinoma. Gain-of-function experiments showed that miR-204-5p inhibits cell invasion by regulating targets involved in epithelial-mesenchymal transition. The inhibition of cell invasion is achieved through direct binding and repression of HMGA2. In vivo experiments confirmed the relationship between miR-204-5p and HMGA2, suggesting that targeting HMGA2 holds promise for thyroid cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Egle-Helene Ervin, Rhiannon French, Chao -Hui Chang, Siim Pauklin
Summary: Cell identity is determined by the transcriptional profile, and in cancer, deregulation of transcription factors allows cancer cells to acquire a stem-like state. These stem-like cancer cells are highly metastatic and therapy resistant. This article reviews recent research findings and describes the role of common transcription factors in maintaining the stemness state.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Eisa Sabouni, Melina Maghsodlou Nejad, Sarah Mojtabavi, Sara Khoshdooz, Mahsa Mojtabavi, Niloufar Nadafzadeh, Negin Nikpanjeh, Sepideh Mirzaei, Mehrdad Hashemi, Amir Reza Aref, Ramin Khorrami, Noushin Nabavi, Yavuz Nuri Ertas, Shokooh Salimimoghadam, Mohammad Arad Zandieh, Parham Rahmanian, Afshin Taheriazam, Kiavash Hushmandi
Summary: Colorectal cancer is a dangerous form of cancer that affects the gastrointestinal tract. The aggressive behavior of tumor cells makes it difficult to treat, leading to poor survival rates for patients. Metastasis is a major challenge in treating CRC, and inhibiting the cancer's ability to invade and spread is necessary to improve prognosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Partha Jyoti Saikia, Lekhika Pathak, Shirsajit Mitra, Bikul Das
Summary: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. Recent studies have shown that oral microbiota play a critical role in the initiation and progression of OSCC by activating inflammatory pathways and stemness pathways in cancer cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Yani Cui, Mingda Zhao, Yuedi Yang, Ruiling Xu, Lei Tong, Jie Liang, Xingdong Zhang, Yong Sun, Yujiang Fan
Summary: A promising combined chemotherapeutic strategy using a targeted co-delivery nanosystem has been developed to overcome abnormal progression in drug-resistant tumor cells and cancer stem cells. The strategy effectively inhibits the Wnt/β-catenin signaling pathway and EMT process, leading to a reduction in tumor growth and metastasis risk.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Zhongbo Zhang, Yuanhong Xu
Summary: This study aimed to investigate the correlation between high FZD7 expression in pancreatic cancer and hepatic metastasis, as well as the related molecular mechanisms. The results showed that high FZD7 expression was associated with liver metastasis, accelerating cancer cell migration by promoting EMT and enhancing cell stemness.
MOLECULAR MEDICINE
(2022)
Article
Food Science & Technology
Kang Ma, Han Chen, Ke Wang, Xue Han, Yue Zhang, Hui Wang, Zhiqiang Hu, Jing Wang
Summary: In this study, it was found that pterostilbene (PTE) can inhibit the metastasis of triple negative breast cancer (TNBC) by reversing the epithelial to mesenchymal transition (EMT) and suppressing stemness. PTE can also inhibit the lung metastasis of TNBC by suppressing the nuclear translocation of beta-catenin.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Fengtian Li, Mengmeng Niu, Kewei Qin, Rongtian Guo, Yong Yi, Jing Xu, Luping Li, Siyi Xie, Mengyuan Fu, Nasi Wen, Wenting Liao, Zhi-Xiong Jim Xiao
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with high risk of metastasis and recurrence. Breast cancer stem cells (BCSCs) are critical in development, metastasis, recurrence, and chemotherapy resistance of breast cancer. FBXL2 serves as a negative regulator of BCSCs stemness and its downregulation plays a causal role in TNBC drug resistance.
Article
Oncology
Seung Tae Kim, Hae-Yun Jung, Jae Sook Sung, Uk Hyun Jo, Tomoaki Tanaka, Koichi Hagiwara, Kyong Hwa Park, Sang Won Shin, Jun Suk Kim, Yeul Hong Kim
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2013)
Article
Oncology
Hae-Yun Jung, Laurent Fattet, Jing Yang
CLINICAL CANCER RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Hae-Yun Jung, Xin Wang, Sohee Jun, Jae-Il Park
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Xin Wang, Shailbala Singh, Hae-Yun Jung, Guojun Yang, Sohee Jun, K. Jagannadha Sastry, Jae-Il Park
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Hae-Yun Jung, Sohee Jun, Moonsup Lee, Han-Cheon Kim, Xin Wang, Hong Ji, Pierre D. McCrea, Jae-Il Park
Article
Cell Biology
Youn-Sang Jung, Sohee Jun, Moon Jong Kim, Sung Ho Lee, Han Na Suh, Esther M. Lien, Hae-Yun Jung, Sunhye Lee, Jie Zhang, Jung-In Yang, Hong Ji, Ji Yuan Wu, Wenqi Wang, Rachel K. Miller, Junjie Chen, Pierre D. McCrea, Scott Kopetz, Jae-Il Park
NATURE CELL BIOLOGY
(2018)
Article
Cell Biology
Hae-Yun Jung, Laurent Fattet, Jeff H. Tsai, Taketoshi Kajimoto, Qiang Chang, Alexandra C. Newton, Jing Yang
NATURE CELL BIOLOGY
(2019)
Article
Oncology
Hyung-Keun Kim, Joo Dong Park, Seung Hee Choi, Dong Jun Shin, Sohyun Hwang, Hae-Yun Jung, Kyung-Soon Park
Article
Cell Biology
Laurent Fattet, Hae-Yun Jung, Mike W. Matsumoto, Brandon E. Aubol, Aditya Kumar, Joseph A. Adams, Albert C. Chen, Robert L. Sah, Adam J. Engler, Elena B. Pasquale, Jing Yang
DEVELOPMENTAL CELL
(2020)
Article
Medicine, Research & Experimental
Hae-Yun Jung, Tae Ho Kim, Jong-Eun Lee, Hong Kwan Kim, Jong Ho Cho, Yong Soo Choi, Sumin Shin, Se-Hoon Lee, Hwanseok Rhee, Hee Kyung Lee, Hyun Jung Choi, Hye Yoon Jang, Seungjae Lee, Jung Hee Kang, Young Ae Choi, Sanghyuk Lee, Jinseon Lee, Yoon La Choi, Jhingook Kim
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Kwang-Soo Kim, Jun-Hyeok Han, Seung Hee Choi, Hae-Yun Jung, Joo Dong Park, Hee-Jung An, Seong-Eun Kim, Dong-Hyun Kim, Junsang Doh, Dong Keun Han, Ik-Hwan Kim, Wooram Park, Kyung-Soon Park
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Minwook Lee, Hyeon-Ju Cho, Kyung-Soon Park, Hae-Yun Jung
Summary: The ELK3 gene plays a crucial role in the migration and invasion of gastric cancer cells, and facilitates cancer cell dissemination by modulating extracellular matrix remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Joo Dong Park, Kwang-Soo Kim, Seung Hee Choi, Gae Hoon Jo, Jin-Ho Choi, Si-Won Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Hye Jung Jang, Sohyun Hwang, Hae-Yun Jung, Kyung-Soon Park
Summary: This study found that the ELK3-Mid51 axis is directly associated with mitochondrial dynamics and NK cell immune response in TNBC, providing new strategies to improve the efficacy of NK cell-based immunotherapy of TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Hae-Yun Jung, Dae-Keum Lee, Minwook Lee, Seung Hee Choi, Joo Dong Park, Eun-Su Ko, Jongwon Lee, Kyung-Soon Park, Hae-Yun Jung
Summary: Triple-negative breast cancer (TNBC) is a challenging subtype due to its aggressive behavior and limited treatment options. Immunotherapy has shown promise in prolonging survival, but its efficacy in solid cancers is limited. This study demonstrates that targeting the ELK3 gene can recruit immune cells, including NK cells, by increasing the expression of the chemokine CXCL16. Low ELK3 expression and high CXCL16 expression are associated with better prognosis and increased expression of NK cell-related genes. Targeting the ELK3 gene could be a strategy to enhance immunotherapy efficacy in TNBC.
