In vivo HSC transduction in rhesus macaques with an HDAd5/3+ vector targeting desmoglein 2 and transiently overexpressing cxcr4

Translational development of a tumor junction opening technology

(2022) Jiho Kim et al.   Scientific Reports

In vivo HSPC gene therapy with base editors allows for efficient reactivation of fetal γ-globin in β-YAC mice

(2021) Chang Li et al.   Blood Advances

Desmoglein‐2 expression is an independent predictor of poor prognosis patients with multiple myeloma

(2021) Lisa M. Ebert et al.   Molecular Oncology

Desmoglein 2 (DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia

(2021) Jing Zhang et al.   VIROLOGICA SINICA

Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors

(2021) Chang Li et al.   Molecular Therapy-Methods & Clinical Development

Chimeric oncolytic Ad5/3 virus replicates and lyses ovarian cancer cells through desmoglein‐2 cell entry receptor

(2020) Lukasz Kuryk et al.   JOURNAL OF MEDICAL VIROLOGY

In Vivo HSC Gene Therapy Using a Bi-modular HDAd5/35++ Vector Cures Sickle Cell Disease in a Mouse Model

(2020) Chang Li et al.   MOLECULAR THERAPY

Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements

(2020) Hongjie Wang et al.   JCI Insight

Desmoglein-2 as a prognostic and biomarker in ovarian cancer

(2020) Jiho Kim et al.   CANCER BIOLOGY & THERAPY

Systemic cancer therapy with engineered adenovirus that evades innate immunity

(2020) Svetlana Atasheva et al.   Science Translational Medicine

Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors

(2019) Chang Li et al.   MOLECULAR THERAPY

Adenovirus vectors in hematopoietic stem cell genome editing

(2019) Chang Li et al.   FEBS LETTERS

Innate immunity to adenovirus: lessons from mice

(2019) Svetlana Atasheva et al.   FEBS LETTERS

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

(2018) Chang Li et al.   BLOOD

A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice

(2018) Hongjie Wang et al.   Molecular Therapy-Methods & Clinical Development

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia

(2018) Hongjie Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates

(2017) Stefan Radtke et al.   Science Translational Medicine

A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis

(2016) Lisa M. Ebert et al.   ANGIOGENESIS

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

(2016) M. Richter et al.   BLOOD

Intracellular Signaling and Desmoglein 2 Shedding Triggered by Human Adenoviruses Ad3, Ad14, and Ad14P1

(2015) Hongjie Wang et al.   JOURNAL OF VIROLOGY

DNA Methylation and Histone Modifications Are the Molecular Lock in Lentivirally Transduced Hematopoietic Progenitor Cells

(2015) Siew Ching Ngai et al.   Biomed Research International

Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin

(2015) Maximilian Richter et al.   Molecular Therapy-Methods & Clinical Development

Structural and Functional Studies on the Interaction of Adenovirus Fiber Knobs and Desmoglein 2

(2013) H. Wang et al.   JOURNAL OF VIROLOGY

Coadministration of Epithelial Junction Opener JO-1 Improves the Efficacy and Safety of Chemotherapeutic Drugs

(2012) I. Beyer et al.   CLINICAL CANCER RESEARCH

Differential effects of the type of iron chelator on the absolute number of hematopoietic peripheral progenitors in patients with  -thalassemia major

(2012) G. L. Forni et al.   HAEMATOLOGICA

A New Human DSG2-Transgenic Mouse Model for Studying the Tropism and Pathology of Human Adenoviruses

(2012) H. Wang et al.   JOURNAL OF VIROLOGY

Ad3-hTERT-E1A, a Fully Serotype 3 Oncolytic Adenovirus, in Patients With Chemotherapy Refractory Cancer

(2012) Otto Hemminki et al.   MOLECULAR THERAPY

Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming

(2012) Gaoyang Liang et al.   NATURE CELL BIOLOGY

Cilostazol enhances integrin-dependent homing of progenitor cells by activation of camp-dependent protein kinase in synergy with Epac1

(2011) Dong Hyung Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Multimerization of Adenovirus Serotype 3 Fiber Knob Domains Is Required for Efficient Binding of Virus to Desmoglein 2 and Subsequent Opening of Epithelial Junctions

(2011) H. Wang et al.   JOURNAL OF VIROLOGY

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

(2010) Hongjie Wang et al.   NATURE MEDICINE

Predictive parameters for granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization

(2008) Akira Okano et al.   JOURNAL OF CLINICAL APHERESIS