Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway

DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production

(2021) Haiyan Zhou et al.   Nature Communications

Melatonin activates ABCA1 via the BiP/NRF1 pathway to suppress high-cholesterol-induced apoptosis of mesenchymal stem cells

(2021) Jun Sung Kim et al.   Stem Cell Research & Therapy

METTL3-mediated m6A modification regulates cell cycle progression of dental pulp stem cells

(2021) Haiyun Luo et al.   Stem Cell Research & Therapy

Activation of AMPK Promotes Maturation of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

(2021) Liang Ye et al.   Frontiers in Cell and Developmental Biology

Alginate/gelatin encapsulation promotes NK cells differentiation potential of bone marrow resident C-kit+ hematopoietic stem cells

(2021) Ezzatollah Fathi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

NRF2 is required for structural and metabolic maturation of human induced pluripotent stem cell-derived ardiomyocytes

(2021) Xinyuan Zhang et al.   Stem Cell Research & Therapy

Mitophagy and apoptosis mediated by ROS participate in AlCl3-induced MC3T3-E1 cell dysfunction

(2021) Menglin Liu et al.   FOOD AND CHEMICAL TOXICOLOGY

Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload

(2021) Siwen Li et al.   JOURNAL OF HAZARDOUS MATERIALS

Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat

(2021) Gloria E. Villalpando-Rodriguez et al.   Oxidative Medicine and Cellular Longevity

IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway

(2020) Mingzhuo Lin et al.   Stem Cell Research & Therapy

Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling

(2020) Xin-fang Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hypoxic preconditioning combined with curcumin promotes cell survival and mitochondrial quality of bone marrow mesenchymal stem cells, and accelerates cutaneous wound healing via PGC-1α/SIRT3/ HIF-1α signaling

(2020) Xujie Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiac differentiation of bone-marrow-resident c-kit+ stem cells by L-carnitine increases through secretion of VEGF, IL6, IGF-1, and TGF-β as clinical agents in cardiac regeneration

(2020) Ezzatollah Fathi et al.   JOURNAL OF BIOSCIENCES

The role of mitochondrial dysfunction in mesenchymal stem cell senescence

(2020) Yibo Wang et al.   CELL AND TISSUE RESEARCH

Mesenchymal stem cells promote caspase expression in Molt-4 leukemia cells via GSK-3α/β and ERK1/2 signaling pathways as a therapeutic strategy

(2020) Ezzatollah Fathi et al.   CURRENT GENE THERAPY

Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism

(2020) Rafael Agustín Burgos et al.   MOLECULES

L-carnitine Extends the Telomere Length of the Cardiac Differentiated CD117+- Expressing Stem Cells

(2020) Ezzatollah Fathi et al.   TISSUE & CELL

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling

(2020) Ye Yu et al.   Frontiers in Immunology

Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis

(2019) Rongkun Li et al.   Molecular Cancer

Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21

(2019) Dae-Seok Kim et al.   MOLECULAR CELL

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

(2019) Ziwen Wang et al.   Nature Communications

INTRAMYOCARDIAL BONE MARROW STEM CELLS IN PATIENTS UNDERGOING CARDIAC SURGICAL REVASCULARIZATION

(2019) Joshua L. Chan et al.   ANNALS OF THORACIC SURGERY

Andrographolide alleviates parkinsonism in MPTP‐PD mice via targeting DRP1‐mediated mitochondrial fission

(2019) Ji Geng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

(2019) Pallab Shaw et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Neuroprotection of Andrographolide Against Microglia-Mediated Inflammatory Injury and Oxidative Damage in PC12 Neurons

(2019) Yuanzhen Xu et al.   NEUROCHEMICAL RESEARCH

The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment

(2019) Qin Zhou et al.   Artificial Cells Nanomedicine and Biotechnology

Haemin pre‐treatment augments the cardiac protection of mesenchymal stem cells by inhibiting mitochondrial fission and improving survival

(2019) Rui Deng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The PI3k/Akt Pathway Is Associated With Angiogenesis, Oxidative Stress and Survival of Mesenchymal Stem Cells in Pathophysiologic Condition in Ischemia

(2019) A. SAMAKOVA et al.   PHYSIOLOGICAL RESEARCH

Andrographolide sulfonate improves Alzheimer-associated phenotypes and mitochondrial dysfunction in APP/PS1 transgenic mice

(2018) Ji Geng et al.   BIOMEDICINE & PHARMACOTHERAPY

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

(2018) Muhammad Torequl Islam et al.   CANCER LETTERS

Improvement in Left Ventricular Function with Intracoronary Mesenchymal Stem Cell Therapy in a Patient with Anterior Wall ST-Segment Elevation Myocardial Infarction

(2018) Su Hyun Kim et al.   CARDIOVASCULAR DRUGS AND THERAPY

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation

(2018) Fan Yang et al.   Cell Death & Disease

Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1-Nrf2-Are signaling pathway

(2018) Bo Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

Mitochondrial quality control as a key determinant of cell survival

(2018) Lucia Sedlackova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells

(2018) W.S. Daniel Tan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway

(2017) Chen-wei Pan et al.   Oncotarget

Coculture of endothelial progenitor cells and mesenchymal stem cells enhanced their proliferation and angiogenesis through PDGF and Notch signaling

(2017) Tangzhao Liang et al.   FEBS Open Bio

Andrographolide protects liver cells from H 2 O 2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A 2a receptor signalling

(2016) Smriti P.K. Mittal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

(2016) Do-Geun Kim et al.   Journal of Neuroinflammation

Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model

(2016) Guang-Wei Zhang et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway

(2016) Ji Tan et al.   MOLECULES

Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism

(2015) Dionysios V. Chartoumpekis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

HGF and IGF-1 promote protective effects of allogeneic BMSC transplantation in rabbit model of acute myocardial infarction

(2015) Guang-Wei Zhang et al.   CELL PROLIFERATION

Specificity and Inhibitory Mechanism of Andrographolide and Its Analogues as Antiasthma Agents on NF-κB p50

(2015) Van Sang Nguyen et al.   JOURNAL OF NATURAL PRODUCTS

The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

(2014) Flavia D. Toledo et al.   ARCHIVES OF TOXICOLOGY

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

(2014) Wenjie Guo et al.   Autophagy

Transplantation of Cerebral Dopamine Neurotrophic Factor Transducted BMSCs in Contusion Spinal Cord Injury of Rats: Promotion of Nerve Regeneration by Alleviating Neuroinflammation

(2014) Hua Zhao et al.   MOLECULAR NEUROBIOLOGY

Clinical feasibility study to detect angiogenesis following bone marrow stem cell transplantation in chronic ischaemic heart failure

(2014) Abdul M. Mozid et al.   NUCLEAR MEDICINE COMMUNICATIONS

Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis

(2014) Annelies Bronckaers et al.   PHARMACOLOGY & THERAPEUTICS

Nitric oxide–mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection

(2013) Manfred Nairz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nrf2 regulates haematopoietic stem cell function

(2013) Jennifer J. Tsai et al.   NATURE CELL BIOLOGY

Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity

(2012) SP Guan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Production of Reactive Oxygen Species by Multipotent Stromal Cells/Mesenchymal Stem Cells upon Exposure to Fas Ligand

(2012) Melanie Rodrigues et al.   CELL TRANSPLANTATION

Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways

(2012) Wenjie Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Redox Sensing by Proteins: Oxidative Modifications on Cysteines and the Consequent Events

(2011) Ying Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

From fibroblast cells to cardiomyocytes: direct lineage reprogramming

(2011) Lei Yang   Stem Cell Research & Therapy

Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia

(2010) Su Jing Chan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differentiation of Allogeneic Mesenchymal Stem Cells Induces Immunogenicity and Limits Their Long-Term Benefits for Myocardial Repair

(2010) Xi-Ping Huang et al.   CIRCULATION

Mesenchymal stem cell therapy: Two steps forward, one step back

(2010) James Ankrum et al.   TRENDS IN MOLECULAR MEDICINE

Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells

(2009) Jian-an Wang et al.   ACTA PHARMACOLOGICA SINICA

A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-κB Pathway

(2009) Zhang Bao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin

(2009) Jing Zhou et al.   BIOCHEMICAL PHARMACOLOGY

Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke

(2009) Xu Cui et al.   NEUROBIOLOGY OF DISEASE

Early Beneficial Effects of Bone Marrow-Derived Mesenchymal Stem Cells Overexpressing Akt on Cardiac Metabolism After Myocardial Infarction

(2009) Massimiliano Gnecchi et al.   STEM CELLS