3,5-T2-an Endogenous Thyroid Hormone Metabolite as Promising Lead Substance in Anti-Steatotic Drug Development?

Development of Thyroid Hormones and Synthetic Thyromimetics in Non-Alcoholic Fatty Liver Disease

(2022) Man Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparative analysis of the effects of long term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high fat diet

(2021) Julika Lietzow et al.   THYROID

Noncanonical Thyroid Hormone Receptor α Action Mediates Arterial Vasodilation

(2021) Daniela Geist et al.   ENDOCRINOLOGY

Safety, Tolerability, and Pharmacokinetics of a Novel Mitochondrial Modulator, TRC150094, in Overweight and Obese Subjects: A Randomized Phase-I Clinical Trial

(2021) Deepa Joshi et al.   Frontiers in Pharmacology

Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes

(2021) Kristina Žuna et al.   Biomolecules

Protective Effects of Thyroid Hormone Deprivation on Progression of Maladaptive Cardiac Hypertrophy and Heart Failure

(2021) Helena Kerp et al.   Frontiers in Cardiovascular Medicine

3,5‐Diiodothyronine protects against cardiac ischaemia–reperfusion injury in male rats

(2021) Ruy Andrade Louzada et al.   EXPERIMENTAL PHYSIOLOGY

Change in Thyroid Hormone Metabolite Concentrations Across Different Thyroid States

(2021) Rutchanna M.S. Jongejan et al.   THYROID

3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action

(2020) Josef Köhrle et al.   Frontiers in Endocrinology

Genomic and Non-Genomic Mechanisms of Action of Thyroid Hormones and Their Catabolite 3,5-Diiodo-L-Thyronine in Mammals

(2020) Marco Giammanco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders

(2020) Federica Saponaro et al.   Frontiers in Medicine

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes

(2019) Leigh Goedeke et al.   Annual Review of Pharmacology and Toxicology

Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3′-diiodo-L-thyronine (3,3′-T2) in Human Serum: A Feasibility Study

(2019) Leonardo Lorenzini et al.   Frontiers in Endocrinology

3,5-Diiodo-L-Thyronine Exerts Metabolically Favorable Effects on Visceral Adipose Tissue of Rats Receiving a High-Fat Diet

(2019) Elena Silvestri et al.   Nutrients

A combined LC-MS/MS and LC-MS3 multi-method for the quantification of iodothyronines in human blood serum

(2019) Keith H. Richards et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

3,5-T2 and 3,3′,5-T3 Regulate Cerebellar Thyroid Hormone Signalling and Myelin Molecular Dynamics in Tilapia

(2019) Y. Hernández-Linares et al.   Scientific Reports

Thyroid Hormone Distributor Proteins During Development in Vertebrates

(2019) Sarah A. Rabah et al.   Frontiers in Endocrinology

Thyroid hormone transporters

(2019) Stefan Groeneweg et al.   ENDOCRINE REVIEWS

Differential Effects of 3,5-Diiodo-L-Thyronine and 3,5,3’-Triiodo-L-Thyronine On Mitochondrial Respiratory Pathways in Liver from Hypothyroid Rats

(2018) Elena Silvestri et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

3,5-Diiodo-l-Thyronine Increases Glucose Consumption in Cardiomyoblasts Without Affecting the Contractile Performance in Rat Heart

(2018) Ginevra Sacripanti et al.   Frontiers in Endocrinology

Thyroid hormone transport across L-type amino acid transporters: What can molecular modelling tell us?

(2017) Gerd Krause et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

(2017) G. Sebastian Hönes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential transcriptome regulation by 3,5-T2 and 3′,3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia

(2017) A. Olvera et al.   Scientific Reports

3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice

(2016) S. da Silva Teixeira et al.   Acta Physiologica

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

(2016) Brian Finan et al.   CELL

3,5-T2alters murine genes relevant for xenobiotic, steroid, and thyroid hormone metabolism

(2016) Julika Lietzow et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

3,5-Diiodo-L-Thyronine (3,5-T2) Exerts Thyromimetic Effects on Hypothalamus-Pituitary-Thyroid Axis, Body Composition, and Energy Metabolism in Male Diet-Induced Obese Mice

(2015) Wenke Jonas et al.   ENDOCRINOLOGY

An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

(2015) Kostja Renko et al.   THYROID

3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats

(2015) Daniel F. Vatner et al.   PLoS One

3,5-Diiodothyronine (T2) is on a role. A new hormone in search of recognition

(2014) Aurea Orozco et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Administration of 3,5‐diiodothyronine (3,5‐T2) causes central hypothyroidism and stimulates thyroid‐sensitive tissues

(2014) Alvaro Souto Padron et al.   JOURNAL OF ENDOCRINOLOGY

Reductions in serum levels of LDL cholesterol, apolipoprotein B, triglycerides and lipoprotein(a) in hypercholesterolaemic patients treated with the liver-selective thyroid hormone receptor agonist eprotirome

(2014) Bo Angelin et al.   JOURNAL OF INTERNAL MEDICINE

The Effect of a Diiodothyronine Mimetic on Insulin Sensitivity in Male Cardiometabolic Patients: A Double-Blind Randomized Controlled Trial

(2014) Fleur van der Valk et al.   PLoS One

Proteomic approaches for the study of tissue specific effects of 3,5,3′-triiodo-L-thyronine and 3,5-diiodo-L-thyronine in conditions of altered energy metabolism

(2014) Elena Silvestri et al.   Frontiers in Physiology

3,5-Diiodo-l-thyronine induces SREBP-1 proteolytic cleavage block and apoptosis in human hepatoma (Hepg2) cells

(2013) Alessio Rochira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Comparison of Constitutive Gene Expression Levels of Hepatic Cholesterol Biosynthetic Enzymes between Wistar-Kyoto and Stroke-Prone Spontaneously Hypertensive Rats

(2013) Kiyomitsu Nemoto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio)

(2013) Alexander G Little et al.   BMC BIOLOGY

3,5-T2Is an Alternative Ligand for the Thyroid Hormone Receptor β1

(2013) A. Mendoza et al.   ENDOCRINOLOGY

Thyroid hormone regulates cardiac performance during cold acclimation in zebrafish (Danio rerio)

(2013) A. G. Little et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

3,5-Diiodo-L-Thyronine Administration To Hypothyroid Rats Rapidly Enhances Fatty Acid Oxidation Rate and Bioenergetic Parameters in Liver Cells

(2013) Alessandro Cavallo et al.   PLoS One

Responses of skeletal muscle lipid metabolism in rat gastrocnemius to hypothyroidism and iodothyronine administration: a putative role for FAT/CD36

(2012) Assunta Lombardi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells

(2012) Adelaide Del Viscovo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PHASE II DRUG METABOLIZING ENZYMES

(2012) Petra Jancova et al.   BIOMEDICAL PAPERS-OLOMOUC

Thyroid Hormone Reduces Cholesterol via a Non-LDL Receptor-Mediated Pathway

(2012) Ira J. Goldberg et al.   ENDOCRINOLOGY

Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography–tandem mass spectrometry

(2012) Sarah A. Hackenmueller et al.   JOURNAL OF CHROMATOGRAPHY A

Metabolic effects of the iodothyronine functional analogue TRC150094 on the liver and skeletal muscle of high-fat diet fed overweight rats: an integrated proteomic study

(2012) Elena Silvestri et al.   Molecular BioSystems

TRC150094 attenuates progression of nontraditional cardiovascular risk factors associated with obesity and type 2 diabetes in obese ZSF1 rats

(2012) Shitalkumar Zambad et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Nonthyrotoxic Prevention of Diet-Induced Insulin Resistance by 3,5-Diiodo-L-Thyronine in Rats

(2011) Pieter de Lange et al.   DIABETES

Thyronamines—Past, Present, and Future

(2011) S. Piehl et al.   ENDOCRINE REVIEWS

3,5-Diiodo-l-thyronine modulates the expression of genes of lipid metabolism in a rat model of fatty liver

(2011) Elena Grasselli et al.   JOURNAL OF ENDOCRINOLOGY

Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

(2011) Romi Ghose et al.   LIFE SCIENCES

Thyroid hormones, mitochondrial bioenergetics and lipid handling

(2011) Federica Cioffi et al.   Current Opinion in Endocrinology Diabetes and Obesity

TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet

(2010) Federica Cioffi et al.   FASEB JOURNAL

Weight Loss after Therapy of Hypothyroidism Is Mainly Caused by Excretion of Excess Body Water Associated with Myxoedema

(2010) Jesper Karmisholt et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pathways affected by 3,5-diiodo-l-thyronine in liver of high fat-fed rats: Evidence from two-dimensional electrophoresis, blue-native PAGE, and mass spectrometry

(2010) Elena Silvestri et al.   Molecular BioSystems

3,5-diiodo-l-thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet

(2009) Maria Pina Mollica et al.   JOURNAL OF HEPATOLOGY

Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates

(2008) Susanne Piehl et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY