Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders
Authors
Keywords
-
Journal
Frontiers in Medicine
Volume 7, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-07-09
DOI
10.3389/fmed.2020.00331
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Thyroid hormone analogues: an update
- (2020) Riccardo Zucchi THYROID
- Potential role of two novel agonists of thyroid hormone receptor‐β on liver regeneration
- (2020) Andrea Perra et al. CELL PROLIFERATION
- Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3′-diiodo-L-thyronine (3,3′-T2) in Human Serum: A Feasibility Study
- (2019) Leonardo Lorenzini et al. Frontiers in Endocrinology
- The role of nuclear receptors in the differentiation of oligodendrocyte precursor cells derived from fetal and adult neural stem cells
- (2019) Vito Antonio Baldassarro et al. Stem Cell Research
- A liver-specific thyromimetic, VK2809, decreases hepatosteatosis in glycogen storage disease type Ia (GSD Ia)
- (2019) Jin Zhou et al. THYROID
- Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
- (2019) Stephen A Harrison et al. LANCET
- Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis
- (2019) Massimiliano Runfola et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain
- (2018) Soledad Bárez-López et al. THYROID
- Effect of Thyroid Hormones on Neurons and Neurodevelopment
- (2018) Giovanni Prezioso et al. Hormone Research in Paediatrics
- A Thyroid Hormone–Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy
- (2017) Meredith D. Hartley et al. ENDOCRINOLOGY
- Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature
- (2017) Frédéric Flamant et al. ENDOCRINOLOGY
- GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease
- (2017) Amedeo Columbano et al. GENE EXPRESSION
- The Thyromimetic KB2115 (Eprotirome) Induces Rat Hepatocyte Proliferation
- (2017) Marta Szydlowska et al. GENE EXPRESSION
- Traversing barriers – How thyroid hormones pass placental, blood-brain and blood-cerebrospinal fluid barriers
- (2017) Kelly Landers et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Sobetirome prodrug esters with enhanced blood–brain barrier permeability
- (2016) Andrew T. Placzek et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
- (2016) Brian Finan et al. CELL
- Increasing Thyromimetic Potency through Halogen Substitution
- (2016) Jordan Devereaux et al. ChemMedChem
- Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges
- (2016) L.P.B. Elbers et al. Current Atherosclerosis Reports
- Thyroid Hormone Receptor β Agonist Induces β-Catenin-Dependent Hepatocyte Proliferation in Mice: Implications in Hepatic Regeneration
- (2016) Tamara Feliciano Alvarado et al. GENE EXPRESSION
- Tissue thyroid hormones and thyronamines
- (2016) Alice Accorroni et al. HEART FAILURE REVIEWS
- 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis
- (2016) Douglas S. Ross et al. THYROID
- 3,5-diiodo-L-thyronine: A Possible Pharmacological Agent?
- (2016) Maria Coppola et al. Current Drug Delivery
- Transferrin and thyroid hormone converge in the control of myelinogenesis
- (2015) L.N. Marziali et al. EXPERIMENTAL NEUROLOGY
- Thyroid Hormone Mediated Modulation of Energy Expenditure
- (2015) Janina Vaitkus et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Nongenomic actions of thyroid hormone
- (2015) Paul J. Davis et al. Nature Reviews Endocrinology
- Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling
- (2015) Lars Grøntved et al. Nature Communications
- The thyroid receptor β modulator GC-1 reduces atherosclerosis in ApoE deficient mice
- (2014) K. Kannisto et al. ATHEROSCLEROSIS
- A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation
- (2014) Emily G. Baxi et al. GLIA
- Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia
- (2014) Martha J. Kelly et al. JOURNAL OF MEDICINAL CHEMISTRY
- Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study
- (2014) Barbara Sjouke et al. Lancet Diabetes & Endocrinology
- Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways
- (2013) Daniel F. Vatner et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Thyroid hormones and mitochondria: With a brief look at derivatives and analogues
- (2013) Federica Cioffi et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Thyroid Hormone Analogues: Where Do We Stand in 2013?
- (2013) Sunitha Meruvu et al. THYROID
- Molecular Functions of Thyroid Hormones and Their Clinical Significance in Liver-Related Diseases
- (2013) Hsiang Cheng Chi et al. Biomed Research International
- Impact of Oatp1c1 Deficiency on Thyroid Hormone Metabolism and Action in the Mouse Brain
- (2012) Steffen Mayerl et al. ENDOCRINOLOGY
- Myelin Gene Regulatory Factor Is Required for Maintenance of Myelin and Mature Oligodendrocyte Identity in the Adult CNS
- (2012) M. Koenning et al. JOURNAL OF NEUROSCIENCE
- A Bimodal Influence of Thyroid Hormone on Cerebellum Oligodendrocyte Differentiation
- (2012) Frédéric Picou et al. MOLECULAR ENDOCRINOLOGY
- Fundamentally Distinct Roles of Thyroid Hormone Receptor Isoforms in a Thyrotroph Cell Line Are due to Differential DNA Binding
- (2012) Maria I. Chiamolera et al. MOLECULAR ENDOCRINOLOGY
- Thyromimetics: A journey from bench to bed-side
- (2011) Ivan Tancevski et al. PHARMACOLOGY & THERAPEUTICS
- Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells
- (2010) Doreen Braun et al. GLIA
- TRβ is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells
- (2010) Marta A. Kowalik et al. JOURNAL OF HEPATOLOGY
- A single prenatal exposure to the endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin alters developmental myelination and remyelination potential in the rat brain
- (2010) M. Fernández et al. JOURNAL OF NEUROCHEMISTRY
- 535 THYROID HORMONE RECEPTOR LIGANDS INDUCE REGRESSION OF RAT PRENEOPLASTIC LIVER LESIONS CAUSING THEIR REVERSION TO A DIFFERENTIATED PHENOTYPE
- (2009) A. Perra et al. JOURNAL OF HEPATOLOGY
- Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes
- (2009) John D. Baxter et al. NATURE REVIEWS DRUG DISCOVERY
- Thyroid hormone (T3) and TRβ agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats
- (2008) Andrea Perra et al. FASEB JOURNAL
- Sobetirome: a case history of bench-to-clinic drug discovery and development
- (2008) Thomas S. Scanlan HEART FAILURE REVIEWS
- Association between hypothyroidism and hepatocellular carcinoma: A case-control study in the United States
- (2008) Manal M. Hassan et al. HEPATOLOGY
- Thyroid hormone receptor alpha1: A switch to cardiac fetal phenotype?
- (2008) C. Xinaris et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Locomotor Deficiencies and Aberrant Development of Subtype-Specific GABAergic Interneurons Caused by an Unliganded Thyroid Hormone Receptor 1
- (2008) K. Wallis et al. JOURNAL OF NEUROSCIENCE
- Effects of Thyroid Hormone Analogs on Lipid Metabolism and Thermogenesis
- (2008) Miriam O. Ribeiro THYROID
- Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms
- (2008) Lucas Bleicher et al. BMC STRUCTURAL BIOLOGY
- Mechanisms of nongenomic actions of thyroid hormone
- (2007) Paul J. Davis et al. FRONTIERS IN NEUROENDOCRINOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search